Pattern of metastatic spread in triple-negative breast cancer

Dent, Rebecca; Hanna, Wedad; Trudeau, Maureen; Rawlinson, Ellen; Sun, Ping; Narod, Steven A.

doi:10.1007/s10549-008-0086-2

Cited by 481 publications

(350 citation statements)

References 23 publications

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“…It had been reported that TNC patients had shorter survival after diagnosing brain metastasis when compared to non TNC counterparts and hence is a poor prognostic indicator (Saip et al, 2009). Consistent with findings reported in Western population (Rodriguez-Pinilla et al, 2006;Dent et al, 2009), we did not find any difference between the TNC and non TNC groups in incidence of bone metastasis.…”

Section: Discussionsupporting

confidence: 90%

“…Majority of studies in the West showed worse prognosis for TNC group within 3-5 years (Tischkowitz et al, 2007;Dent et al, 2009), and some suggested the differences between TNC and non-TNC regarding overall survival wear off at 10 years of follow-up (Tischkowitz et al, 2007). In this aspect, we observed a similar breast cancer-specific mortality rate, disease-free survival and overall survival between groups.…”

Section: Discussionsupporting

confidence: 74%

“…On the other hand, Rodriguez-Pinilla et al reported that triple negative breast cancer had a higher percentage of local recurrence (Rodriguez-Pinilla et al, 2006). Dent et al (2009) also concluded that concluded that triple negative breast cancer were four times more likely to experience a visceral metastasis within five years of diagnosis than those with other types of cancer. In our cohort, TNC was also found to have a worse outcome and was 2.69 times more likely to experience visceral relapse.…”

Section: Discussionmentioning

confidence: 99%

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Triple Negative Status is a Poor Prognostic Indicator in Chinese Women with Breast Cancer: a Ten Year Review

Chau²,

Wong³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

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Triple Negative Status is a Poor Prognostic Indicator in Chinese Women with Breast Cancer: a Ten Year Review

Chau²,

Wong³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Studies of the spread of breast cancer have shown that a longer interval free of pleural metastases is an indicator of a worse prognosis, (8,10,11) and this poor prognosis has been associated with factors such as the site of the metastasis and the identification of malignant cells in the pleural fluid (23) ; the expression of c-erbB-2 (21) ; the triple-negative phenotype (11,(15)(16)(17) ; and Ki-67 protein expression, which has been shown to be present in 63% of patients with malignant pleural effusion. (18,24,25) The worst breast cancer survival rates are in developing countries.…”

Section: Resultsmentioning

confidence: 99%

Fatores clínicos e anatomopatológicos que influenciam a sobrevida de pacientes com câncer de mama e derrame pleural neoplásico

et al. 2012

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Objective: The objective of this study was to identify the clinical and pathological factors that can influence the prognosis of breast cancer patients with clinical symptoms of malignant pleural effusion. Methods: This was a clinical cohort study, in which we analyzed the medical charts of patients diagnosed with malignant pleural effusion between 2006 and 2010. By examining the charts, we identified the female patients with a history of breast cancer. For those patients, we collected pathology data related to the primary tumor and cytopathology data related to the pleural metastasis. Results: We evaluated 145 patients, 87 (60%) of whom had tested positive for malignant cells in the pleural fluid. Ductal histology was observed in 119 (82%). The triple-negative breast cancer phenotype was seen in 25 cases (17%). Those patients had the worst prognosis (with a sharp decline in the survival curve), and 20 of the 25 (80%) died during the follow-up period (through June of 2011). The mean survival after the identification of malignant pleural effusion was 6 months. Conclusions: In patients with triple-negative breast cancer who test positive for malignant cells in the pleural fluid, the prognosis is poor and survival is reduced.Keywords: Pleural effusion, malignant/mortality; Breast neoplasms/mortality; Breast neoplasms/genetics. ResumoObjetivo: O objetivo deste estudo foi identificar os fatores clínicos e anatomopatológicos que possam influenciar o prognóstico de pacientes com câncer de mama e sintomas clínicos de derrame pleural neoplásico. Métodos: Trata-se de um estudo clínico de coorte, no qual foram analisados os prontuários médicos de pacientes que receberam diagnóstico de derrame pleural neoplásico entre 2006 e 2010. Por meio da análise dos prontuários, identificamos as pacientes com história de câncer de mama. Para essas pacientes, coletamos dados anatomopatológicos relacionados ao tumor primário e dados citopatológicos relacionados à metástase pleural. Resultados: Das 145 pacientes avaliadas, 87 (60%) apresentaram, no exame citológico, resultado positivo para células neoplásicas no líquido pleural; além disso, 119 (82%) apresentaram tipo histológico ductal. O fenótipo triplo-negativo foi observado em 25 pacientes (17%), as quais apresentaram o pior prognóstico, com queda acentuada na curva de sobrevida. Das 25 pacientes, 20 (80%) evoluíram a óbito durante o período de seguimento (até junho de 2011). A sobrevida média após a identificação de derrame pleural neoplásico foi de 6 meses. Conclusões: Em pacientes com câncer de mama triplo-negativo e exame citológico com resultado positivo para células neoplásicas no líquido pleural, o prognóstico é ruim e a sobrevida é menor. cancer who develop pleural effusion. To that end, we evaluated factors related to the diagnosis, the histological type of the primary tumor, the identification of malignant cells in the pleural fluid, the expression of immunohistochemical markers of breast cancer, and outcomes. MethodsThis was a hospital-based, historical cohort study...

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“…TNBC is associated with shortened disease-free interval post-surgery and post-adjuvant treatment and, ultimately, a shortened overall survival. [12][13][14][15] Furthermore, TNBCs are themselves a heterogeneous group within which the claudinlow subtype is associated with worst prognosis. 16 Compared to the overall prevalence of breast cancer, a limited number of reports have indicated exosomes and/or microvesicles to be of relevance in breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Exosomes from triple-negative breast cancer cells can transfer phenotypic traits representing their cells of origin to secondary cells

O’Brien

Rani

Corcoran

et al. 2013

European Journal of Cancer

203

161

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Background: Triple-negative breast cancer (TNBC) accounts for 15-20% of breast cancers but is responsible for a disproportionate number of deaths. We investigated the relevance, in TNBC, of nano-sized exosomes expelled from cells. Specifically, we compared effects of exosomes derived from the claudin-low TNBC cell line Hs578T and its more invasive Hs578Ts(i) 8 variant, as well as exosomes from TNBC patient sera compared to normal sera. Methods: Exosomes were isolated from conditioned media (CM) of Hs578T and Hs578Ts(i) 8 cells and from sera by filtration and ultracentrifugation. Successful isolation was confirmed by transmission electron microscopy and immunoblotting. Subsequent analysis, of secondary/ recipient cells in response to exosomes, included proliferation; motility/migration; invasion; anoikis assays and endothelial tubule formation assays. Results: Hs578Ts(i) 8 -exosomes versus Hs578T-exosomes significantly increased the proliferation, migration and invasion capacity of all three recipient cell lines evaluated i.e. SKBR3, MDA-MB-231 and HCC1954. Exosomes from Hs578Ts(i) 8 cells also conferred increased invasiveness to parent Hs578T cells. Hs578Ts(i) 8 -exosomes increased sensitivity of SKBR3, MDA-MB-231 and HCC1954 to anoikis when compared to the effects of Hs578T-exosomes reflecting the fact that Hs578Ts(i) 8 cells are themselves innately more sensitive to anoikis. In relation to vasculogenesis and subsequent angiogenesis, Hs578Ts(i) 8 -exosomes versus Hs578T-exosomes stimulated significantly more endothelial tubules formation. Finally, our 0959-8049/$ -see front matter Ó

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Pattern of metastatic spread in triple-negative breast cancer

Abstract: The excess risk of distant recurrence in triple-negative breast cancers, versus other forms of cancer, is attributable in large part to an excess of visceral metastases in the first five years following diagnosis.

Cited by 481 publications

References 23 publications

Triple Negative Status is a Poor Prognostic Indicator in Chinese Women with Breast Cancer: a Ten Year Review

Triple Negative Status is a Poor Prognostic Indicator in Chinese Women with Breast Cancer: a Ten Year Review

Fatores clínicos e anatomopatológicos que influenciam a sobrevida de pacientes com câncer de mama e derrame pleural neoplásico

Exosomes from triple-negative breast cancer cells can transfer phenotypic traits representing their cells of origin to secondary cells

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