Pattern of Motor and Cognitive Deficits in Detoxified Alcoholic Men

Sullivan, Edith V.; Rosenbloom, Margaret J.; Pfefferbaum, Adolf

doi:10.1111/j.1530-0277.2000.tb02032.x

Cited by 403 publications

(214 citation statements)

References 87 publications

Supporting

Mentioning

189

Contrasting

Unclassified

Order By: Relevance

“…For example, various studies have observed fluency deficits in users of alcohol (Noël et al 2001), cannabis (Croft et al 2001), and MDMA (Bhattachary and Powell 2001;Fox et al 2001). Similarly, there is growing evidence of working memory deficits in users of alcohol (Sullivan et al 2000), cocaine (Goldstein et al 2004), opiates (Mintzer and Stitzer 2002), and MDMA (Gouzoulis-Mayfrank et al 2003;Wareing et al 2000). There is also a large amount of evidence about the existence of deficits in reasoning (especially in cocaine users) on tasks similar to the similarities subtest used in this study (Easton and Bauer 1996;Di Sclafani et al 2002;Gillen et al 1998).…”

Section: Igt Performancementioning

confidence: 80%

Profile of executive deficits in cocaine and heroin polysubstance users: common and differential effects on separate executive components

2006

View full text Add to dashboard Cite

show abstract

Section: Igt Performancementioning

confidence: 80%

Profile of executive deficits in cocaine and heroin polysubstance users: common and differential effects on separate executive components

2006

View full text Add to dashboard Cite

show abstract

“…Typically, the processes affected are visuospatial abilities, executive functions, and gait and balance (for reviews, see Fein et al 1990;Moselhy et al 2001;Oscar-Berman 2000;Sullivan 2000), evidenced in both alcoholic men (Sullivan et al 2000d) and women (Sullivan et al 2002b). The executive functions affected include working memory, problem solving, temporal or- Fig.…”

Section: White Matter In Normal Aging and Alcoholismmentioning

confidence: 97%

Neurocircuitry in alcoholism: a substrate of disruption and repair

2005

View full text Add to dashboard Cite

The chronic, excessive consumption of alcohol results in significant modification of selective neural systems of the brain structure, physiology, and function. Quantitative MR structural imaging, diffusion tensor imaging (DTI), and functional MRI (fMRI), together with neuropsychological challenges, have enabled rigorous in vivo characterization of the results of alcoholism on the brain in the human condition. Neuroimaging has also enabled longitudinal study for the examination of alcoholism's dynamic course through periods of drinking and sobriety. Controlled studies have revealed compelling evidence for alcohol-related brain structural and functional modification--some longstanding, some transient, and some compensatory. Patterns of circuitry disruption identified through structural and functional MRI studies suggest a central role for degradation of frontocerebellar neuronal nodes and connecting circuitry affecting widespread brain regions and contributing to alcoholism's salient, enduring, and debilitating cognitive and motor deficits--executive dysfunction, visuospatial impairment, and ataxia.

show abstract

“…For example, Melgaard et al (1990) and Volkow et al (1992) assessed chronic effects on rCBF and showed metabolic reversible decreases after detoxification (Volkow et al, 1994). There may be continuing effects on executive and visuospatial abilities, (Sullivan, Rosenbloom, & Pfefferbaum, 2000;Mann et al, 2001) (Bates et al, 1997), suggesting prefrontal and parietal damage, and stable over 21 days of treatment.…”

Section: Introductionmentioning

confidence: 92%

Using Virtual Reality to Study Alcohol Intoxication Effects on the Neural Correlates of Simulated Driving

Calhoun

Carvalho

Astur

et al. 2005

Appl Psychophysiol Biofeedback

View full text Add to dashboard Cite

The use of virtual reality in the form of simulated tasks can provide a realistic environment in which to study complex naturalistic behaviors. Many of the behavioral effects of alcohol intoxication are well known, but there is relatively little imaging evidence examining how alcohol exposure might transiently modulate brain function, especially in the context of task performance. In this review, we provide a brief synopsis of previous work using functional magnetic resonance imaging (fMRI) to study the neural correlates of alcohol intoxication. We describe in detail two studies from our published work, the first involving a visual perception paradigm, and the second involving virtual reality through a naturalistic behavior; simulated driving. Participants received single-blind individualized doses of beverage alcohol designed to produce blood alcohol content (BAC) of 0.04 and 0.08 or placebo. Subjects were fMRI scanned after training to asymptote performance. In both studies we found specific circuits that were differentially modulated by alcohol, we revealed both global and local effects of alcohol, and we examined relationships between behavior, brain function, and alcohol blood levels.

show abstract

Pattern of Motor and Cognitive Deficits in Detoxified Alcoholic Men

Cited by 403 publications

References 87 publications

Profile of executive deficits in cocaine and heroin polysubstance users: common and differential effects on separate executive components

Profile of executive deficits in cocaine and heroin polysubstance users: common and differential effects on separate executive components

Neurocircuitry in alcoholism: a substrate of disruption and repair

Using Virtual Reality to Study Alcohol Intoxication Effects on the Neural Correlates of Simulated Driving

Contact Info

Product

Resources

About