Pattern of posterior capsule opacification models 2 years postoperatively with 2 single-piece acrylic intraocular lenses

Abstract

Eyes with an IOL with a continuous 360-degree square edge had significantly less PCO than eyes with an IOL with a square edge that was interrupted at the optic-haptic junction.

The Effect of Single-Piece Hydrophobic Acrylic Intraocular Lenses on the Development of Posterior Capsule Opacification

“…This could cause a loss of barrier function to migrating lens epithelial cells, which may worsen PCO inhibition. [25][26][27][28] In the present study, there was no significant difference in PCO from 3 to 5 years after surgery. We believe that the existing migratory lens epithelial cells at the optic-haptic junction or beneath the IOL optic create a tight barrier effect against the posterior capsule preventing the migration of lens epithelial cells towards central visual axis.…”

Prevention of capsular bag opacification with a new hydrophilic acrylic disk-shaped intraocular lens

“…This is in marked contrast to the control IOLs, which showed a large amount of proliferative cortical material anteriorly and posteriorly with significant ACO and PCO, the latter starting at the optic-haptic junctions. This is especially remarkable because the control IOL was chosen for its uninterrupted 360-degree barrier edge; results in a clinical study 25 showed that the uninterrupted 360-degree barrier edge led to significantly less PCO than a 1-piece interrupted-edge hydrophobic acrylic IOL 2 years after implantation. Modifications of the current design of the study IOL to further reduce capsular bag opacification were proposed, and additional rabbit studies are underway.…”

Economic considerations related to choice of intraocular lens (IOL) and posterior capsule opacification frequency – a comparison of three different IOLs

“…Unfortunately, the posterior capsule acts as a substrate for the ingrowth of cells and fibrosis, leading to PCO and often to a significant secondary vision loss. The most common treatment for PCO is neodymium:yttrium-aluminium-garnet (Nd:YAG) laser capsulotomy to restore a clear visual axis (Nixon & Woodcock 2011). PCO has been subject to much research, and several potential causes have been identified.…”