PATTERN OF RELAPSED DISEASE IN CHILDHOOD ALL: Experience from a Single Tertiary Care Center in North India

Abstract

The study was designed to determine the pattern of relapsed disease and identify problem areas in management. Relapse occurred in 111 (23.9%) of the boys and 16 (13.0%) of the girls. The majority relapsed while on chemotherapy. Isolated relapse in the marrow and in the CNS was seen in 51 (40.8%) and 24 (18.9%) patients, respectively. Isolated testicular relapse was seen in 17 (15.3%) of the 111 boys who suffered a relapse. Age and TLC at initial presentation and gender in relapsers and nonrelapsers were compared. Multivariate regression analysis showed that gender (p = .03) and TLC (p = .001) were significant predictors of relapse. Relapse of disease while on chemotherapy and high incidence of CNS and testicular relapse indicate the need for reappraisal of treatment protocols.

Pattern and determinants of central nervous system relapse in childhood acute lymphoblastic leukemia in a resource-limited setting

“…[1] Forty-five (8.46%) patients developed CNS relapse. Isolated and combined CNS relapse was documented in 24 (4.52%) and 21 (3.94%) cases, respectively.…”