Pattern recognition receptors in microbial keratitis

Taube, M-A; Cendra, Maria del Mar; Elsahn, Ahmad; Christodoulides, Myron; Hossain, Parwez

doi:10.1038/eye.2015.118

Cited by 25 publications

(28 citation statements)

References 207 publications

(192 reference statements)

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“…The content of micelle 2 in zinc was determined by XRF spectroscopy and was 6.4± 0.8 % wt, which corresponds to dispersion of 1 in the SLS by 18.9% wt. This leads to a [SLS]: [1] molar ratio equal to 8.6 which is in agreement to the value obtained for CMC (8.7).…”

Section: Thermo Gravimetric Analysis Of the Compositesupporting

confidence: 90%

“…Due to the low solubility of the 1 in aqueous media, the micelle 2 is formed, using the SLS as surfactant. In order to assert the formation of the 2, the determination of the CMC was performed via potentiometric titration at 36 °C [25] and the graph of conductivity values vs [SLS]/ [1] is drawn ( Figure S3). Above the CMC value, surfactant molecules self-agglomerate to form the micelles [26].…”

Section: Determination Of Critical Micelle Concentration (Cmc)mentioning

confidence: 99%

“…The CMC in case of 2, was determined as follows: a solution of SLS (2 × 10 −2 M) in ddH 2 O was added to 20 mL ddH 2 O solution of 1 (8.9 × 10 −4 M) in portions of 1 mL, while the conductivity values were being recorded subsequently. The CMC value is obtained at [SLS]: [1]molar ratio of 8.7 ( Figure S3). Thus, by mixing its components in a molar ratio [SLS]:[1] = 8.7 the composite 2, is formed.…”

Section: Preparation and Characterization Of Micellementioning

confidence: 99%

“…Microbial keratitis often leads to blindness, unless if it is immediately treated. Ocular infection is either caused by misuse contact lens or a wide variety of pathogens [1][2][3]. However, contact lenses have become a major etiology for microbial keratitis, nowadays [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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An Efficient Disinfectant, Composite Material {SLS@[Zn3(CitH)2]} as Ingredient for Development of Sterilized and Non Infectious Contact Lens

et al. 2019

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The [Zn3(CitH)2] (1) (CitH4= citric acid), was dispersed in sodium lauryl sulphate (SLS) to form the micelle of SLS@[Zn3(CitH)2] (2). This material 2 was incorporated in hydrogel made by hydroxyethyl-methacrylate (HEMA), an ingredient of contact lenses, toward the formation of pHEMA@(SLS@[Zn3(CitH)2]) (3). Samples of 1 and 2 were characterized by UV-Vis, 1H-NMR, FT-IR, FT-Raman, single crystal X-ray crystallography, X-ray fluorescence analysis, atomic absorption and TG/DTA/DSC. The antibacterial activity of 1–3 as well as of SLS against Gram-positive (Staphylococcus epidermidis (St. epidermidis) and Staphylococcus aureus (St. aureus)) and Gram-negative (Pseudomonas aeruginosa (PAO1), and Escherichia coli (E. coli)) bacteria was evaluated by the means of minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and inhibitory zone (IZ). 2 showed 10 to 20-fold higher activity than 1 against the bacteria tested. Moreover the 3 decreases the abundance of Gram-positive microbes up to 30% (St. aureus) and up to 20% (PAO1) the Gram-negative ones. The noteworthy antimicrobial activity of the obtained composite 3 suggests an effective antimicrobial additive for infection-free contact lenses.

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Section: Thermo Gravimetric Analysis Of the Compositesupporting

confidence: 90%

Section: Determination Of Critical Micelle Concentration (Cmc)mentioning

confidence: 99%

Section: Preparation and Characterization Of Micellementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An Efficient Disinfectant, Composite Material {SLS@[Zn3(CitH)2]} as Ingredient for Development of Sterilized and Non Infectious Contact Lens

et al. 2019

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“…It activates pattern recognition receptors in the cornea causing inflammation. Leukocytes, predominantly neutrophils, infiltrate the cornea and the anterior chamber of the eye (1,2). The infection and inflammation often lead to corneal ulcers and consecutive blindness.…”

Section: Introductionmentioning

confidence: 99%

Bacterial keratitis: Photodynamic inactivation reduced experimental inflammation

Deichelbohrer

Seitz

et al. 2017

Exp Ther Med

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Abstract. The successful treatment of bacterial keratitis remains an unsolved clinical problem. The current study aimed to establish a murine keratitis model and to investigate the effect of chlorin e6 (Ce6) and photodynamic inactivation (PDI) on corneal inflammation. The cornea of anesthetized mice was scratched and covered with a bacterial suspension of Pseudomonas aeruginosa. A paste containing Ce6 was applied to the cornea with subsequent exposure to specified light. Two days later the animals were sacrificed, and the globes were processed for light microscopy. Evaluation parameters were the maximal corneal thickness and the severity of the hypopyon. The maximal corneal thickness of 290±16 µm in the infected and untreated group was significantly reduced to 220±8 µm in the infected and treated group (P<0.05). In addition, the hypopyon was less severe in the infected and treated group. In conclusion, the present study indicates that PDI using Ce6 may be a potential approach to treat patients suffering with severe bacterial keratitis.

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Advances in the Field of Microbial Infection in the Cornea and the Role of Nanotechnology in Treating Keratitis

Al-Mashahedah

Kanwar

2018

Drug Delivery for the Retina and Posterior Segment Disease

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Pattern recognition receptors in microbial keratitis

Abstract: Microbial keratitis is a significant cause of global visual impairment and blindness. Corneal infection can be caused by a wide variety of pathogens, each of which exhibits a range of mechanisms by which the immune system is activated.

Cited by 25 publications

References 207 publications

An Efficient Disinfectant, Composite Material {SLS@[Zn3(CitH)2]} as Ingredient for Development of Sterilized and Non Infectious Contact Lens

An Efficient Disinfectant, Composite Material {SLS@[Zn3(CitH)2]} as Ingredient for Development of Sterilized and Non Infectious Contact Lens

Bacterial keratitis: Photodynamic inactivation reduced experimental inflammation

Advances in the Field of Microbial Infection in the Cornea and the Role of Nanotechnology in Treating Keratitis

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