Patterns and Dynamics of Subventricular Zone Neuroblast Migration in the Ischemic Striatum of the Adult Mouse

Zhang, Rui L.; Chopp, Michael; Gregg, Sara R; Toh, Yier; Roberts, Cindi; LeTourneau, Yvonne; Buller, Benjamin; Jia, Longfei; Nejad-Davarani, Siamak P.; Zhang, Zheng G.

doi:10.1038/jcbfm.2009.55

Cited by 107 publications

(116 citation statements)

References 46 publications

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“…25,33 Studies in rodent models of stroke have shown the proliferation and migration of new neurons that appear to travel to the injured striatum and cortex within 24 hours and up to 6 weeks after injury. 5,36,48,77 In one report, stroke in adult mice caused neuroblasts to migrate in chains from the SVZ to the striatum at an average speed of 28.67 μm/hr. 77 Several TBI studies using a cortical impact injury model in mice and rats have demonstrated new neurons near the focal site of injury from 3 days to 3 weeks postinjury.…”

Section: Discussionmentioning

confidence: 99%

“…5,36,48,77 In one report, stroke in adult mice caused neuroblasts to migrate in chains from the SVZ to the striatum at an average speed of 28.67 μm/hr. 77 Several TBI studies using a cortical impact injury model in mice and rats have demonstrated new neurons near the focal site of injury from 3 days to 3 weeks postinjury. 7,66,70 Indeed, Covey et al 13 showed that the critical period for neocortical neurogenesis in postnatal Day 6 mice was between 4 and 7 days after cryoinjury.…”

Section: Discussionmentioning

confidence: 99%

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Maturation-dependent response of neurogenesis after traumatic brain injury in children

Taylor

Smith²,

Harris

et al. 2013

PED

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Object Traumatic brain injury (TBI) is the leading cause of acquired disability in children, yet innate repair mechanisms are incompletely understood. Given data from animal studies documenting neurogenesis in response to trauma and other insults, the authors investigated whether similar responses could be found in children of different ages after TBI. Methods Immunohistochemistry was used to label doublecortin (DCX), a protein expressed by immature migrating neuroblasts (newborn neurons), in specimens from patients ranging in age from 3 weeks to 10 years who had died either after TBI or from other causes. Doublecortin-positive (DCX+) cells were examined in the subventricular zone (SVZ) and periventricular white matter (PWM) and were quantified within the granule cell layer (GCL) and subgranular zone (SGZ) of the dentate gyrus to determine if age and/or injury affect the number of DCX+ cells in these regions. Results The DCX+ cells decreased in the SVZ as patient age increased and were found in abundance around a focal subacute infarct in a 1-month-old non-TBI patient, but were scarce in all other patients regardless of age or history of trauma. The DCX+ cells in the PWM and dentate gyrus demonstrated a migratory morphology and did not co-localize with markers for astrocytes, microglia, or macrophages. In addition, there were significantly more DCX+ cells in the GCL and SGZ of the dentate gyrus in children younger than 1 year old than in older children. The density of immature migrating neuroblasts in infants (under 1 year of age) was significantly greater than in young children (2–6 years of age, p = 0.006) and older children (7–10 years of age, p = 0.007). Conclusions The main variable influencing the number of migrating neuroblasts observed in the SVZ, PWM, and hippocampus was patient age. Trauma had no discernible effect on the number of migrating neuroblasts in this cohort of patients in whom death typically occurred within hours to days after TBI.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Maturation-dependent response of neurogenesis after traumatic brain injury in children

Taylor

Smith²,

Harris

et al. 2013

PED

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“…70,84 Also like the cells in the SGL, those NPCs that do survive migrate out of the SVZ into the striatum and neocortex and mature into functional neurons. 73,[85][86][87][88][89] In addition, it has been demonstrated that transient angiogenesis after stroke allows neuroblasts to migrate along these newly formed blood vessels aiding in their migration out of the SVZ. 89 While some of these newly generated neurons survive up to 5 weeks after ischemia, the majority seem to die with only B0.2% of the cells surviving.…”

Section: Effect Of Ischemia On Neurogenesismentioning

confidence: 99%

Neurogenesis and Inflammation after Ischemic Stroke: What is Known and Where We Go from Here

Tobin

Bonds

Minshall

et al. 2014

J Cereb Blood Flow Metab

303

236

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This review covers the pathogenesis of ischemic stroke and future directions regarding therapeutic options after injury. Ischemic stroke is a devastating disease process affecting millions of people worldwide every year. The mechanisms underlying the pathophysiology of stroke are not fully understood but there is increasing evidence demonstrating the contribution of inflammation to the drastic changes after cerebral ischemia. This inflammation not only immediately affects the infarcted tissue but also causes long-term damage in the ischemic penumbra. Furthermore, the interaction between inflammation and subsequent neurogenesis is not well understood but the close relationship between these two processes has garnered significant interest in the last decade or so. Current approved therapy for stroke involving pharmacological thrombolysis is limited in its efficacy and new treatment strategies need to be investigated. Research aimed at new therapies is largely about transplantation of neural stem cells and using endogenous progenitor cells to promote brain repair. By understanding the interaction between inflammation and neurogenesis, new potential therapies could be developed to further establish brain repair mechanisms.

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“…Dividing neuroblasts undergo tangential migration in the RMS, and then radial migration up into the OB, where they differentiate into two groups of functional interneurons: granule cells (GCs) and juxtaglomerular neurons (JGNs) [3][4][5][6][7][8][9][10]. Whereas the dynamics of SVZ cell migration as well as the tangential migration of neuroblasts in, and their detachment from the RMS, have been studied in much detail [10][11][12][13][14][15][16], little is known about their migratory behavior within the OB.…”

Section: Introductionmentioning

confidence: 99%

Long-term in vivo single-cell tracking reveals the switch of migration patterns in adult-born juxtaglomerular cells of the mouse olfactory bulb

Liang

Riecken

et al. 2016

Cell Res

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The behavior of adult-born cells can be easily monitored in cell culture or in lower model organisms, but longitudinal observation of individual mammalian adult-born cells in their native microenvironment still proves to be a challenge. Here we have established an approach named optical cell positioning system for long-term in vivo single-cell tracking, which integrates red-green-blue cell labeling with repeated angiography. By combining this approach with in vivo two-photon imaging technique, we characterized the in vivo migration patterns of adult-born neurons in the olfactory bulb. In contrast to the traditional view of mere radial migration of adult-born cells within the bulb, we found that juxtaglomerular cells switch from radial migration to long distance lateral migration upon arrival in their destination layer. This unique long-distance lateral migration has characteristic temporal (stop-and-go) and spatial (migratory, unidirectional or multidirectional) patterns, with a clear cell age-dependent decrease in the migration speed. The active migration of adult-born cells coincides with the time period of initial fate determination and is likely to impact on the integration sites of adult-born cells, their odor responsiveness, as well as their survival rate.

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Patterns and Dynamics of Subventricular Zone Neuroblast Migration in the Ischemic Striatum of the Adult Mouse

Cited by 107 publications

References 46 publications

Maturation-dependent response of neurogenesis after traumatic brain injury in children

Maturation-dependent response of neurogenesis after traumatic brain injury in children

Neurogenesis and Inflammation after Ischemic Stroke: What is Known and Where We Go from Here

Long-term in vivo single-cell tracking reveals the switch of migration patterns in adult-born juxtaglomerular cells of the mouse olfactory bulb

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