Patterns and risk factors of peripherally inserted central venous catheter-related symptomatic thrombosis events in patients with malignant tumors receiving chemotherapy

Chen, Yanliang; Chen, Hong; Yang, Jianqi; Jin, Weiguo; Fu, Deyuan; Liu, Min; Xu, Yan; Tao, Zhifang; Li, Ying; Lü, Lin; Wang, Mingzhu; Zhu, Caiyun; Chen, Yong

doi:10.1016/j.jvsv.2020.01.010

Cited by 31 publications

(19 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Otherwise, mechanical prophylaxis to prevent thrombus should be performed. In addition, this study also suggested that age, BMI, APACHE II score, length of ICU stay and other factors were signi cantly different in the comparison between the two groups, which was basically consistent with the results of previous studies 12,16,17,43 .…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Disease-Related Risk Factors for CVC-Related Symptomatic Thrombosis in Surgical ICU Inpatients

Liu

Zhu

Kuang

et al. 2020

Preprint

View full text Add to dashboard Cite

To report the rate of symptomatic catheter-related venous thrombosis (CRVT) in surgical intensive care unit patients receiving central venous catheters (CVC) and analyze the disease-related risk factors for symptomatic CRVT in SICU patients. A retrospective analysis was performed on 1643 critically ill patients admitted to the SICU from January 2015 to December 2019. Cases were divided into two groups based on the presence of symptomatic CRVT, and the variables of interest were extracted from the electronic medical record system. Logistic univariate and multivariate regression analyses were used to determine the risk factors of SCRVT. A total of 209 symptomatic CRVT events occurred among 2114 catheters. Multivariate analysis showed that trauma (odds ratio [OR], 2.046; 95% confidence interval [CI] [1.325-3.160], P = 0.001), major surgery (OR, 2.457; 95% CI [1.641-3.679], P = 0.000), and heart failure (OR, 2.087; 95% CI [1.401-3.111], P = 0.000) were independent risk factors for symptomatic CRVT in SICU. The AUROC for this model was 0.610 (95% CI [0.569-0.651], P=0.000). The incidence rate was 9.89%. For patients hospitalized in the SICU, especially those admitted with these three conditions, thromboprophylaxis and/or mechanical prophylaxis should be actively provided to reduce the occurrence of symptomatic CRVT.

show abstract

Section: Discussionsupporting

confidence: 91%

“…However, the incidence of symptomatic CRVT was not further analyzed 16 . Chen, Y. et al studied symptomatic thrombosis associated with peripherally inserted CVC in cancer patients and found that the incidence of symptomatic CRVT was 6.7% 17 . The incidence of symptomatic CRVT in our study was 9.89%.…”

Section: Discussionmentioning

confidence: 99%

Disease-Related Risk Factors for CVC-Related Symptomatic Thrombosis in Surgical ICU Inpatients

Liu

Zhu

Kuang

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Patient-related factors included malignancy, recent trauma or surgery, history of deep vein thrombosis (DVT), age >60 years. Medication-related factors included chemotherapy, kinds of infusion liquids, and the use of prophylactic anticoagulants (Al-Asadi et al, 2019;Chen et al, 2020;Ellis et al, 2020;Fallouh et al, 2015;Song et al, 2020). Previous studies had limitations such as a relatively small sample size and a lack of systematic examination of the risk factors (Al-Asadi et al, 2019;Chen et al, 2020;Kang et al, 2017a).…”

Section: Backg Rou N Dmentioning

confidence: 99%

“…Medication‐related factors included chemotherapy, kinds of infusion liquids, and the use of prophylactic anticoagulants (Al‐Asadi et al, 2019; Chen et al., 2020; Ellis et al., 2020; Fallouh et al, 2015; Song et al., 2020). Previous studies had limitations such as a relatively small sample size and a lack of systematic examination of the risk factors (Al‐Asadi et al, 2019; Chen et al., 2020; Kang et al, 2017a). Collectively, there is a need to determine the incidence and risk factors associated with PICC‐RT in patients with lung cancer while addressing the above limitations.…”

Section: Introductionmentioning

confidence: 99%

Incidence and risk factors of symptomatic thrombosis related to peripherally inserted central catheter in patients with lung cancer

Chen

Wan

Zhu

2020

Journal of Advanced Nursing

View full text Add to dashboard Cite

Aims To determine the incidence and risk factors associated with peripherally inserted central catheter‐related thrombosis (PICC‐RT) in patients with lung cancer. Design A retrospective cross‐sectional design. Methods Patients with lung cancer receiving PICC insertion during 1 March 2014‐31 May 2019 at a tertiary hospital in Shanghai, China were enrolled (N = 748). Symptomatic PICC‐RT was confirmed by Doppler ultrasonography in the presence of clinical symptoms and signs. Univariate and multivariate logistic regression analyses were performed to identify risk factors of symptomatic PICC‐RT. Results Among the patients (mean age, 60.7 years; males, 67.1%), 55 (7.35%) had symptomatic PICC‐RT. Based on the multivariate analysis, history of smoking [OR 2.49 (1.13–5.46), p < .05], use of Carboplatin [OR 2.23 (1.19–4.17), p < .05] or Docetaxel [OR 7.23 (1.65–31.56), p < .05], PICC size [OR 3.52 (1.78–6.99), p < .001], and level of D‐dimer [OR 5.32 (2.39–11.83), p < .001] were significant risk factors of PICC‐RT. Conclusion Several modifiable factors (e.g., PICC size and level of D‐dimer) were related to PICC‐RT. In the future, prospective studies are warranted to examine whether those factors could increase the risk of PICC‐RT. Meanwhile, healthcare professionals are recommended to perform a comprehensive assessment of the patients receiving PICC insertion. Close attention should be paid to those at risk for PICC‐RT. Impact Identification of risk factors associated with PICC‐RT is an important step towards individualizing the care plan for patients receiving PICC. Our findings provided evidence for the management of PICC‐RT in patients with lung cancer. In clinical practice, nurses could deliver appropriate interventions against modifiable risk factors to reduce the risk of PICC‐RT.

show abstract

“…Rates of CVCT reported vary substantially depending on the population studied, ranging from 5% to 18%. 2,17 In a large metropolitan Australian study of 3130 cancer patients, Ellis et al 18 found that CVCT occurred in 3.6% of all central catheters, and 4.9% for those with a PICC. Our rates of thrombosis were slightly higher, likely reflecting our higher risk population: 29.6% of our patients had very high risk cancers, as opposed to 4.1% in the study by Ellis et al…”

Section: Discussionmentioning

confidence: 99%

Central Venous Catheter Thrombosis in Cancer: A Multi-Centre Retrospective Study Investigating Risk Factors and Contemporary Trends in Management

Haggstrom

Parmar

Brungs

2020

Clin Med Insights Oncol

View full text Add to dashboard Cite

Objectives: Central venous access is needed to facilitate chemotherapy for many cancer patients. Central venous catheter-related thrombosis (CVCT) is a major complication that can cause significant morbidity and mortality. We sought to explore the rate of CVCT in a general cancer population in Australia and to identify factors associated with increased risk of thrombosis. Design: This is a multi-centre retrospective cohort study. Setting and participants: We analysed key patient, treatment, and cancer-related factors for 317 patients with cancer and central venous catheters inserted for systemic therapy. Main outcome measures: Symptomatic CVCT confirmed with imaging and management of patients with CVCT. Results: A total of 402 cases of central line insertion were analysed. Central venous catheter-related thrombosis occurred in 24 patients (6.0%). Having a peripherally inserted central catheter (PICC; HR = 3.78, 95% CI = 1.28-11.19, P = .02) compared with an implantable port and a body mass index of ⩾25.0 kg/m2 (HR = 3.60, 95% CI = 1.31-9.85, P = .01) were independently associated with increased risk of thrombosis. Central venous catheter-related thrombosis was managed mostly with removal of the catheter (19 of 24 cases) and anticoagulation, including direct-acting oral anticoagulants in 5 patients. Conclusions: This work explored rates of CVCT in a general cancer population, observing increased rates in those with PICCs or increased body mass index.

show abstract

Patterns and risk factors of peripherally inserted central venous catheter-related symptomatic thrombosis events in patients with malignant tumors receiving chemotherapy

Cited by 31 publications

References 40 publications

Disease-Related Risk Factors for CVC-Related Symptomatic Thrombosis in Surgical ICU Inpatients

Disease-Related Risk Factors for CVC-Related Symptomatic Thrombosis in Surgical ICU Inpatients

Incidence and risk factors of symptomatic thrombosis related to peripherally inserted central catheter in patients with lung cancer

Central Venous Catheter Thrombosis in Cancer: A Multi-Centre Retrospective Study Investigating Risk Factors and Contemporary Trends in Management

Contact Info

Product

Resources

About