Patterns and time of recurrence after complete resection of esophageal cancer

Shimada, Masahiko; Morita, Masaru; Yoshida, Rika; Ando, Koji; Egashira, Akinori; Ohga, Takefumi; Saeki, Hiroshi; Oki, Eiji; Kakeji, Yoshihiro; Sakaguchi, Yoshihisa; Maehara, Yoshihiko

doi:10.1007/s00595-012-0133-9

Cited by 73 publications

(73 citation statements)

References 22 publications

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“…after curative esophagectomy, followed by distant organ recurrence [3,9,10]. These studies have also demonstrated that distant organ recurrence had a poorer prognosis than loco-regional recurrence.…”

Section: Introductionmentioning

confidence: 94%

Patterns and Outcomes of Recurrent Esophageal Cancer After Curative Esophagectomy

et al. 2017

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Section: Introductionmentioning

confidence: 94%

Patterns and Outcomes of Recurrent Esophageal Cancer After Curative Esophagectomy

et al. 2017

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“…In order to find out the failure pattern after surgery, several retrospective studies had been investigated and advices were A retrospective study of pattern of recurrence after radical surgery for thoracic esophageal carcinoma with or without postoperative radiotherapy concluded for clinic target delineation (22)(23)(24)(25). However, these researches were focused on the patients without PRT.…”

Section: Introductionmentioning

confidence: 99%

A retrospective study of pattern of recurrence after radical surgery for thoracic esophageal carcinoma with or without postoperative radiotherapy

Wang

Zhang

et al. 2018

Oncol Lett

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Abstract. The present study aimed to investigate the recurrence pattern of thoracic esophageal cancer (TEC) following radical surgery for guiding postoperative radiotherapy (PRT). Patterns of recurrence were analyzed in patients with recurrence for the first time after radical surgery at the First Affiliated Hospital of Anhui Medical University (Anhui, China) from January 2012 to December 2015. A total of 244 patients were reviewed in the study. The mean recurrence time for patients with PRT was >1 month longer than that for patients without PRT. The lymphatic, anastomotic and hematological recurrence ratios were 87.9 vs. 69.2%, 4.0 vs. 11.5% and 8.0 vs. 17.2%, respectively for patients without and with PRT. The most common recurrence regions were staion1 and station 2-4 (30.0 vs. 36.5% and 37.2% vs. 23.1%, respectively, for patients without and with PRT). The lymphatic recurrence of upper TEC was almost in station1 and station 2-4 (infield). The middle and lower TEC also had a high probability of lymphatic recurrence in station 1 and station 2-4 (totally 76.3 vs. 57.6% and 61.9 vs. 61.1%, respectively). The recurrence ratio significantly decreased in station 2-4 (infield) for middle TEC patients with PRT compared with patients without PRT (P= 0.03), while no significant differences in the lymphatic recurrence ratios were observed in other regions (P>0.05). The differences of recurrence ratios in station 7, station 8 and celiac regions (infield) for lower TEC patients without and with PRT also demonstrated no statistical significance (P>0.05). The results of the present study indicated that the lower neck, supraclavicular regions and upper mediastinal regions (station 1, 2 and 4) should be included in the clinic target volume (CTV) for PRT, while lower mediastinal regions, celiac regions and anastomotic may not be included in CTV.

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“…Lou et al (15) in a recently published study found that 54% of recurrences were detected in the first year of follow-up and 75% in the second year. Other series published at international level (4,10,16) concur in concluding that the majority of recurrences are detected during the first 2 years of follow-up.…”

Section: Discussionmentioning

confidence: 68%

“…Surgery involving oesophagectomy is still the main therapeutic option (2,3), although even after receiving curative treatment the possibility of recurrence in patients, either locoregional or distant, is still high, with percentages varying between 29% and 59% (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Characteristics and pattern of recurrence after curative surgery in oesophageal cancer

et al. 2015

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Background and aim: Recurrence in oesophageal cancer continues to remain high after curative surgery. The aim of this study was to determine the presence of recurrence after curative surgery during follow-up, and the associated variables.Methods: A retrospective and prospective follow-up study in patients with an anatomical-pathological diagnosis of oesophageal cancer who underwent curative surgery (n = 57) in the health district of A Coruña (Spain) during the period [2003][2004][2005][2006][2007][2008]. The calculation of recurrence-free survival was made using a competing risks survival analysis.Results: Out of the 57 patients included in the study, 87.7% were men with a mean age of 61.4 ± 10.3 years. The median follow-up period was 18.5 months, during which 28 recurrences were detected (50.9%). Patients with dysphagia on diagnosis of the disease, as well as patients in stages III-IV, have a higher probability of recurrence during the follow-up period. The median disease-free interval was 8.5 months. After one year of follow up, 57.1% of the recurrences were diagnosed and 82.1% after 2 years of followup. The median post-recurrence survival rate was 4.7 months. After adjusting for a multivariate regression model, the variable with an independent effect for predicting recurrence is the TNM classification (HR = 8.49).Conclusions: The majority of the recurrences will be developed during the 2 years after surgery, with a very poor prognosis. The predictor variable for recurrence is the TMN classification.

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Patterns and time of recurrence after complete resection of esophageal cancer

Abstract: These findings reinforce the importance of careful follow-up for both loco-regional and hematogenous recurrence after esophagectomy, particularly during the first 2 years.

Cited by 73 publications

References 22 publications

Patterns and Outcomes of Recurrent Esophageal Cancer After Curative Esophagectomy

Patterns and Outcomes of Recurrent Esophageal Cancer After Curative Esophagectomy

A retrospective study of pattern of recurrence after radical surgery for thoracic esophageal carcinoma with or without postoperative radiotherapy

Characteristics and pattern of recurrence after curative surgery in oesophageal cancer

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