Patterns of FOXE1 Expression in Papillary Thyroid Carcinoma by Immunohistochemistry

Bychkov, Andrey; Saenko, Vladimir; Nakashima, Masahiro; Mitsutake, Norisato; Rogounovitch, Tatiana; Nikitski, Alyaksandr V.; Orim, Florence; Yamashita, Shunichi

doi:10.1089/thy.2012.0466

Cited by 35 publications

(36 citation statements)

References 53 publications

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“…LD between rs965513 and rs1867277 is significantly weaker in populations of African or Asian ancestry [20], which is not surprising, since the LD block structure may be different in individuals of different ancestry [22]. In our study we observed LD between rs965513, rs1867277, and rs1443434; however, that between rs1867277 and rs1443434 was the strongest.…”

Section: Prace Oryginalnesupporting

confidence: 51%

Wiek zachorowania i płeć jako czynniki modyfikujące związek polimorfizmów zlokalizowanych na chromosomie 9q22 i 14q13 z rakiem brodawkowatym tarczycy

Kula

Kalemba

Puch

et al. 2017

Endokrynologia Polska

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Introduction: Papillary thyroid cancer (PTC) shows familial occurrence, and some susceptibility single nucleotide polymorphisms (SNPs) have been identified in FOXE1 and near the NKX2-1 locus. The aim of our study was to analyse the association of PTC risk with SNPs in FOXE1 (rs965513, rs1867277, rs1443434) and near the NKX2-1 locus (rs944289) in a Polish population, and, in the second step, the interaction between SNPs and patient-related factors (age at diagnosis and gender). Material and methods: A total of 2243 DNA samples from PTC patients and 1160 controls were included in the study. The SNP analysis was performed with the allelic discrimination technique. Results: There were significant associations of all SNPs with PTC (rs965513 odds ratio [OR] = 1.72, p = 8 × 10

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Section: Prace Oryginalnesupporting

confidence: 51%

Wiek zachorowania i płeć jako czynniki modyfikujące związek polimorfizmów zlokalizowanych na chromosomie 9q22 i 14q13 z rakiem brodawkowatym tarczycy

Kula

Kalemba

Puch

et al. 2017

Endokrynologia Polska

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“…The relationship of FOXE1 to thyroid cancer may additionally be illustrated by immunohistochemical studies of FOXE1 expression in thyroid tumors (27)(28)(29). There has been a profound difference between staining patterns in different types of neoplastic tissues.…”

Section: Discussionmentioning

confidence: 99%

The Common Genetic Variant rs944289 on Chromosome 14q13.3 Associates with Risk of Both Malignant and Benign Thyroid Tumors in the Japanese Population

Rogounovitch

Bychkov

Takahashi

et al. 2015

Thyroid

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“…In the context of thyroid carcinoma, several studies have focused on relating FOXE1 expression and localization in cancer cells to tumor development. For instance, FOXE1 overexpression has been described in PTC (Nonaka et al 2008, Bychkov et al 2013, as well as a gradual decrease in its nuclear expression according to the degree of tumor dedifferentiation, along with cytoplasmic accumulation (Zhang et al 2006). This abnormal localization of FOXE1 could be related to thyroid tumorigenesis.…”

Section: Introductionmentioning

confidence: 99%

FOXE1 regulates migration and invasion in thyroid cancer cells and targets ZEB1

Morillo-Bernal

Fernández

Santisteban

2020

Endocrine-Related Cancer

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FOXE1 is a thyroid-specific transcription factor essential for thyroid gland development and maintenance of the differentiated state. Interestingly, a strong association has been recently described between FOXE1 expression and susceptibility to thyroid cancer, but little is known about the mechanisms underlying FOXE1-induced thyroid tumorigenesis. Here, we used a panel of human thyroid cancer-derived cell lines covering the spectrum of thyroid cancer phenotypes to examine FOXE1 expression and to test for correlations between FOXE1 expression, the allele frequency of two SNPs and a length polymorphism in or near the FOXE1 locus associated with cancer susceptibility, and the migration ability of thyroid cancer cell lines. Results showed that FOXE1 expression correlated with differentiation status according to histological sub-type, but not with SNP genotype or cell migration ability. However, loss-and-gain-of-function experiments revealed that FOXE1 modulates cell migration, suggesting a role in epithelial-to-mesenchymal transition (EMT). Our previous genome-wide expression analysis identified Zeb1, a major EMT inducer, as a putative Foxe1 target gene. Indeed, gene silencing of FOXE1 decreased ZEB1 expression, whereas its overexpression increased ZEB1 transcriptional activity. FOXE1 was found to directly interact with the ZEB1 promoter. Lastly, ZEB1 silencing decreased the ability of thyroid tumoral cells to migrate and invade, pointing to its importance in thyroid tumor mestastases. In conclusion, we have identified ZEB1 as a bona fide target of FOXE1 in thyroid cancer cells, which provides new insights into the role of FOXE1 in regulating cell migration and invasion in thyroid cancer.

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Patterns of FOXE1 Expression in Papillary Thyroid Carcinoma by Immunohistochemistry

Cited by 35 publications

References 53 publications

Wiek zachorowania i płeć jako czynniki modyfikujące związek polimorfizmów zlokalizowanych na chromosomie 9q22 i 14q13 z rakiem brodawkowatym tarczycy

Wiek zachorowania i płeć jako czynniki modyfikujące związek polimorfizmów zlokalizowanych na chromosomie 9q22 i 14q13 z rakiem brodawkowatym tarczycy

The Common Genetic Variant rs944289 on Chromosome 14q13.3 Associates with Risk of Both Malignant and Benign Thyroid Tumors in the Japanese Population

FOXE1 regulates migration and invasion in thyroid cancer cells and targets ZEB1

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