Patterns of gray matter atrophy in dementia with Lewy bodies: a voxel-based morphometry study

Watson, Rosie; O’Brien, John T.; Barber, Robert; Blamire, Andrew M.

doi:10.1017/s1041610211002171

Cited by 58 publications

(74 citation statements)

References 33 publications

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“…We have previously reported the patterns of gray matter atrophy in this group 12 and found very few areas of significant volume loss in DLB when compared to controls. Interestingly, there was a trend toward a posterior pattern of atrophy in DLB, although this did not reach statistical significance.…”

Section: Subject Demographicsmentioning

confidence: 60%

“…All subjects underwent clinical and neuropsychological evaluations with diagnostic procedures previously employed by our group. 12 Thirtyfive control subjects were recruited from among relatives and friends of subjects with dementia or volunteered via advertisements in local community newsletters.…”

Section: Methods Subject Recruitment and Assessmentmentioning

confidence: 99%

“…It is unlikely that such an effect size would account for the highly significant pattern of parieto-occipital FA change. 12 Therefore, white matter tract degeneration may be a more sensitive marker and a more prominent feature of DLB, and longitudinal studies are needed to help address this.…”

Section: Subject Demographicsmentioning

confidence: 99%

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Characterizing dementia with Lewy bodies by means of diffusion tensor imaging

et al. 2012

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Objective: To investigate patterns of in vivo white matter tract change using diffusion tensor imaging (DTI), we conducted a cross-sectional study of dementia with Lewy bodies (DLB) in comparison with Alzheimer disease (AD) and normal aging. Methods:The study included 106 subjects (35 with DLB, 36 with AD, and 35 elderly controls) who underwent clinical and neuropsychological assessment and diffusion tensor MRI. We used tract-based spatial statistics to investigate patterns of reduced fractional anisotropy (FA) and increased mean diffusivity (MD) across the entire white matter tract skeleton and also investigated correlations with clinical features. Results:Areas of reduced FA in subjects with DLB vs controls were found primarily in parietooccipital white matter tracts; in AD, the changes were much more diffuse. DLB was also associated with reduced FA in the pons and left thalamus, in comparison with AD. The pattern of MD increase was diffuse in AD and DLB. We found an association between DTI parameters and impaired episodic memory, letter fluency, and severity of motor parkinsonism in DLB. Conclusions:Despite a similar level of dementia severity, patterns of DTI changes in AD and DLB differed significantly. The selective involvement of the visual association areas and subcortical structures and the significant clinical correlations highlight the potential importance of white matter tract change in the pathogenesis of DLB. DTI may be a useful technique to investigate early and possible preclinical changes in DLB and warrants further investigation. Neurology Dementia with Lewy bodies (DLB) is a common form of neurodegenerative dementia in older people, second to Alzheimer disease (AD). The separation between AD and DLB clinically remains a challenge. We therefore need to establish in vivo biomarkers that can distinguish the differing pathologies and their contribution to the clinical features of the conditions. Diffusion tensor imaging (DTI) utilizes the anisotropic nature of diffusion in neuronal white matter tracts.1 With neuronal degeneration, the mean diffusivity (MD) increases with the loss of structural barriers that normally restrict diffusion, and diffusion becomes less directionally oriented, which is associated with a reduction in fractional anisotropy (FA). 2Previous studies investigating the DTI changes in DLB have used conventional region of interest (ROI) or voxel-based morphometry (VBM) methods.3-8 Some studies found widespread FA changes in comparison with healthy controls, 3,7 whereas others have found very little

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Section: Subject Demographicsmentioning

confidence: 60%

Section: Methods Subject Recruitment and Assessmentmentioning

confidence: 99%

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Characterizing dementia with Lewy bodies by means of diffusion tensor imaging

et al. 2012

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“…Hippocampal AD pathology is also a feature of DLB, as previous imaging studies have consistently demonstrated that the level of hippocampal atrophy observed in DLB is less than in AD (Hashimoto et al, 1998; Tam et al, 2005; Burton et al, 2009; Watson et al, 2012), and the level of atrophy relates to concurrent AD pathology measured post mortem (Burton et al, 2009; Kantarci et al, 2012). The extent of the atrophy may also influence the subsequent clinical course of DLB, as individuals with higher levels of hippocampal atrophy have a shorter survival time compared with those with lower levels of atrophy (Graff‐Radford et al, 2016).…”

Section: Introductionmentioning

confidence: 96%

The influence of hippocampal atrophy on the cognitive phenotype of dementia with Lewy bodies

Elder

Mactier

Colloby

et al. 2017

Int J Geriat Psychiatry

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ObjectiveThe level of hippocampal atrophy in dementia with Lewy bodies (DLB) is typically less than that observed in Alzheimer's disease (AD). However, it is not known how the cognitive phenotype of DLB is influenced by hippocampal atrophy or the atrophy of adjacent medial temporal lobe structures.MethodsDementia with Lewy bodies (n = 65), AD (n = 76) and control (n = 63) participants underwent 3T magnetic resonance imaging and cognitive Cambridge Cognitive Examination and Mini‐Mental State Examination (CAMCOG and MMSE) assessments. Hippocampal volume, and parahippocampal, entorhinal and temporal pole cortical thickness, was compared between groups. Regression models were used to investigate whether hippocampal volume and cortical thickness associated with global cognition and cognitive subdomains.ResultsDementia with Lewy bodies, AD and control participants showed significantly different hippocampal, parahippocampal and entorhinal cortical thinning, where atrophy was greatest in AD and intermediate in DLB. Temporal pole thickness was reduced in DLB and AD compared with control participants. In DLB, but not AD, hippocampal volume associated with total CAMCOG, CAMCOG memory and MMSE scores. In DLB, parahippocampal, entorhinal and temporal pole thickness associated with total CAMCOG and CAMCOG memory scores, parahippocampal thickness associated with MMSE scores, and entorhinal thickness associated with CAMCOG executive function scores.ConclusionsIn this large sample, these results are in agreement with other studies indicating that hippocampal atrophy is less severe in DLB than AD. Hippocampal atrophy and medial temporal lobe cortical thickness were associated with the severity of cognitive symptoms, suggesting that atrophy in these structures, as a potential proxy of AD pathology, may partly mediate specific DLB cognitive symptoms. © 2017 The Authors. International Journal of Geriatric Psychiatry Published by John Wiley & Sons Ltd.

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“…In the 2011 awards, the second and third place winning papers by Allan et al (2012) and Watson et al (2012) dealt respectively with white matter change in late life depression and gray matter changes in Dementia with Lewy bodies (DLB). Indeed, the paper of Taylor et al (2013) is the second DLB imaging paper from Newcastle-upon-Tyne to win an award in two consecutive award rounds.…”

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confidence: 99%

The 2013 International Psychogeriatric Association Junior Research Awards in Psychogeriatrics

Ames¹

2013

Int. Psychogeriatr.

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Judging for the 2013 International Psychogeriatric Association (IPA) Junior Research Awards in Psychogeriatrics was undertaken by a panel of six experts, selected by the IPA executive, which I had the honor to chair. All three award-winning papers appear in this issue of International Psychogeriatrics immediately following this guest editorial. I am confident that, like their many predecessors awarded over more than two decades, they will be highly cited (Pachana, 2012) and will be seen in due course as crucial to the development of the young and very promising researchers who have received this prestigious acknowledgment of their excellent work.

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Patterns of gray matter atrophy in dementia with Lewy bodies: a voxel-based morphometry study

Abstract: DLB is associated with less gray matter atrophy and relative preservation of the medial temporal lobe when compared to AD. Degree of medial temporal atrophy may be a useful imaging biomarker and our results provide support for its inclusion in the revised consensus criteria for DLB.

Cited by 58 publications

References 33 publications

Characterizing dementia with Lewy bodies by means of diffusion tensor imaging

Characterizing dementia with Lewy bodies by means of diffusion tensor imaging

The influence of hippocampal atrophy on the cognitive phenotype of dementia with Lewy bodies

The 2013 International Psychogeriatric Association Junior Research Awards in Psychogeriatrics

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