Patterns of Initial Antibiotic Therapy for Community-Acquired Pneumonia in U.S. Hospitals, 2000 to 2009

Antibiotic Prescribing for Adults Hospitalized in the Etiology of Pneumonia in the Community Study

“…A study by Berger et al using data from >100 US hospitals found that 54% of ward CAP patients from 2000 to 2009 received a fluoroquinolone or a beta-lactam plus a macrolide for initial therapy in the 24 hours after admission, which is comparable with our findings showing 52% of ward patients received these recommended IDSA/ATS regimens [28]. However, Berger et al also showed that 23% still received vancomycin (as compared with 12% in our study), and the use of vancomycin almost doubled from 2000 to 2009, which may reflect increasing concerns about MRSA infections.…”

The global threat of antimicrobial resistance: science for intervention

“…Antimicrobial consumption also shows huge interhospital differences that might be partially explained by case mix as well as by differences in the flow of patients carrying resistance bacteria that are transferred from other healthcare facilities [21,22] .…”

Derivation and Multicenter Validation of the Drug Resistance in Pneumonia Clinical Prediction Score

“…Treatment with extended-spectrum antibiotics is recommended for patients meeting at least one of the HCAP criteria (9). Following publication of these guidelines, the rate of use of vancomycin and extended-spectrum antibiotics with activity against Gram-negative bacteria for the treatment of pneumonia doubled (10,11). However, the outcomes among patients that meet the HCAP criteria and that are treated with guideline-concordant therapy have not improved (12)(13)(14).…”