Patterns of keratins 8, 18 and 19 during gonadal differentiation in the mouse: sex- and time-dependent expression of keratin 19

Appert, Alexandre; Fridmacher, Valérie; Locquet, Odette; Magre, Solange

doi:10.1046/j.1432-0436.1998.6350273.x

Cited by 30 publications

(9 citation statements)

References 53 publications

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“…The presence of AE1/AE3 cytokeratin staining in epithelial-type blastemal cells adjacent to the celomic epithelium, with loss of immunoreactivity in deeper cells, could indicate that these cells are arising from the superficial celomic epithelium and further maturating into Sertoli cells that lack cytokeratin expression, which is consistent with the normally observed pattern of cytokeratin expression in the developing testis [1]. The hypothesis of an origin in the celomic epithelium for epithelial blastemal [9] cells is reinforced by the presence of a continuous basement membrane between the celomic epithelium and the blastemal cords, as shown by collagen IV stains.…”

Section: Discussionsupporting

confidence: 79%

The spectrum of persistence of testicular blastema and ectopic testicular parenchyma: a possible result of focal delay in gonadal development

et al. 2007

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Sex-cord formation and organization are important steps in testicular development and depend on adequate interactions between mesenchymal cells, pre-Sertoli cells, and germ cells. These elements form the testicular blastema, the precursor of the testicular parenchyma, morphologically characterized by poorly organized sex cords and mesenchymal components. Here, we study two uncommon testicular lesions, unrelated to other gonadal anomalies. In the first group, we describe the features of persistence of testicular blastema in three fetal autopsy cases, discussing its possible pathogenesis and clinical importance. In the second, we analyze 11 cases of ectopic testicular parenchyma in the tunica albuginea, an uncommon benign condition of uncertain clinical significance, whose main differential diagnosis is gonadal dysgenesis. Based on their similar topography within the testis, and on their possibly shared embryological origin, we propose that both lesions may represent the two extremes of a maldevelopmental spectrum resulting from a focal delay in testicular development.

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Section: Discussionsupporting

confidence: 79%

The spectrum of persistence of testicular blastema and ectopic testicular parenchyma: a possible result of focal delay in gonadal development

et al. 2007

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“…To date, no keratins have been localized to mature Sertoli cells, although keratin 19 mRNA was detected in the genomic array analysis described above (Table 10.4) [60]. Thus, vimentin is the primary, if not the sole, intermediate filament protein in Sertoli cells, and its stage-specific pattern of expression matches that of its transcript [61] (Table 10.4).…”

Section: Intermediate Filamentsmentioning

confidence: 95%

Stage-specific gene expression by Sertoli cells

Wright

2015

Sertoli Cell Biology

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“…KRT18 is expressed in many epithelia other than periderm, including trophectoderm 56 , embryonic surface ectoderm 57; 58 , oral epithelia 59 , embryonic cornea 59 , gonad 60 , bladder 61 , choroid plexus 62 and others. To test the prediction that SNP2 lies in a periderm enhancer, we engineered a 701 bp element centered on SNP2, and harboring either the risk or non-risk allele of it, into the GFP reporter vector.…”

Section: Reporter Assays In Human Oral Epithelium Cells Support Snp2 mentioning

confidence: 99%

Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near humanKRT8/18

Liu

Duncan

Helverson

et al. 2020

Preprint

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Genome wide association studies for non-syndromic orofacial cleft (OFC) have identified single nucleotide polymorphisms (SNPs) at loci where the presumed risk-relevant gene is expressed in oral periderm. The functional subsets of such SNPs are difficult to predict because the sequence underpinnings of periderm enhancers are unknown. We applied ATAC-seq to models of human palate periderm, including zebrafish periderm, mouse embryonic palate epithelia, and a human oral epithelium cell line, and to complementary mesenchymal cell types. We identified sets of enhancers specific to the epithelial cells and trained gapped-kmer support-vector-machine classifiers on these sets. We used the classifiers to predict the effect of 14 OFC-associated SNPs at 12q13 near KRT18.All the classifiers picked the same SNP as having the strongest effect, but the significance was highest with the classifier trained on zebrafish periderm. Reporter and deletion analyses support this SNP as lying within a periderm enhancer regulating KRT18/KRT8 expression.

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Patterns of keratins 8, 18 and 19 during gonadal differentiation in the mouse: sex- and time-dependent expression of keratin 19

Cited by 30 publications

References 53 publications

The spectrum of persistence of testicular blastema and ectopic testicular parenchyma: a possible result of focal delay in gonadal development

The spectrum of persistence of testicular blastema and ectopic testicular parenchyma: a possible result of focal delay in gonadal development

Stage-specific gene expression by Sertoli cells

Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near humanKRT8/18

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