Patterns of outcome and toxicity after salvage prostatectomy, salvage cryosurgery and salvage brachytherapy for prostate cancer recurrences after radiation therapy: a multi-center experience and literature review

Abstract

This overview shows clinical practice of prostate cancer salvage. Significant failure and toxicity rates are observed, regardless of salvage technique. Patients should be selected with great care before offering these salvage treatment strategies.

High-dose-rate stereotactic body radiation therapy for postradiation therapy locally recurrent prostatic carcinoma: Preliminary prostate-specific antigen response, disease-free survival, and toxicity assessment

“…1 Although a wide variety of potential salvage treatment methods exist, all come with potentially increased local toxicity risk versus primary treatment, which limits their use. 2,3 Salvage radical prostatectomy has been used with efficacy in carefully selected cases, but at the cost of a higher local complication rate versus de novo radical prostatectomy. [4][5][6][7] Selective implantation of an artificial urinary sphincter reduced the incidence of incontinence in 1 salvage prostatectomy series.…”

Cryosurgery would be An Effective Option for Clinically Localized Prostate Cancer: A Meta-analysis and Systematic Review

“…In total, 10 papers from seven studies with 1252 patients (561 for CS vs RT, 745 for CS vs RP and 54 for both) were finally included for pooling in our study567891011121314 (Fig. 1).…”

“…Seven papers567891011 from five studies reported the comparison between CS and RT, from which two articles78 based on one study presented results in mean follow-ups of 37 months and 105.2 months, respectively, results from one study were presented simultaneously in two papers910. Both these studies were RCTs.…”

“…One study was prospective5 and two studies were retrospective611. Three studies were also conducted for primary treatment of PCa, one11 for salvage treatment after primary RT and one for both primary and salvage treatments5. Only one study had provided available materials for both comparisons11.…”

“…For comparison between CS and RP, a total of four studies11121314 were involved in the analysis, of which one was prospective whereas three were retrospective. Furthermore, two studies each revealed the results of primary1214 and salvage1113 procedures.…”