2024
DOI: 10.3389/fphar.2024.1438127
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Paving the way ahead: protocol optimization of mouse models in crush syndrome related acute kidney injury research

Ou Qiao,
Xinyue Wang,
Zizheng Li
et al.

Abstract: BackgroundsCrush syndrome (CS) is the leading cause of death after earthquakes, second only to direct trauma. Acute kidney injury (AKI) is the most severe complication of CS. Research based on the CS-AKI mouse model and kidney function assessment by glomerular filtration rate (GFR) helps to elucidate the pathogenesis of CS-AKI, which contributes to effective treatment measures.MethodsMice were modeled by the multi-channel small animal crushing platform. We set up different CS-AKI modeling parameters by applyin… Show more

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