Pax 6: mastering eye morphogenesis and eye evolution

Gehring, Walter J.; Ikeo, Kazuho

doi:10.1016/s0168-9525(99)01776-x

Cited by 684 publications

(408 citation statements)

References 37 publications

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“…The developmental deficiency of Pax6 Sey/Sey ES cells appeared to be restricted to eye development, because hematopoietic cells, cardiac muscle cells, neuronal cells, and melanocytes were induced normally (data not shown). This effect of the mutation of Pax6, whose function in eye development is well conserved throughout the animal kingdom (Gehring and Ikeo, 1999), indicates that these eye-like structures were formed according to the normal developmental program for the vertebrate eye.…”

Section: Characterization Of the Eyelike Structuresmentioning

confidence: 97%

Generation of structures formed by lens and retinal cells differentiating from embryonic stem cells

Hirano

Yamamoto

Yoshimura

et al. 2003

Developmental Dynamics

101

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Embryonic stem cells have the potential to give rise to all cell lineages when introduced into the early embryo. They also give rise to a limited number of different cell types in vitro in specialized culture systems. In this study, we established a culture system in which a structure consisting of lens, neural retina, and pigmented retina was efficiently induced from embryonic stem cells. Refractile cell masses containing lens and neural retina were surrounded by retinal pigment epithelium layers and, thus, designated as eye-like structures. Developmental processes required for eye development appear to proceed in this culture system, because the formation of the eye-like structures depended on the expression of Pax6, a key transcription factor for eye development. The present culture system opens up the possibility of examining early stages of eye development and also of producing cells for use in cellular therapy for various diseases of the eye. Developmental Dynamics 228:664 -671, 2003.

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Section: Characterization Of the Eyelike Structuresmentioning

confidence: 97%

Generation of structures formed by lens and retinal cells differentiating from embryonic stem cells

Hirano

Yamamoto

Yoshimura

et al. 2003

Developmental Dynamics

101

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“…One of the most well-studied of transcription factor genes is one that is known as PAX6 [23,24]. PAX6 plays a crucial part in the development of the eye, and an understanding of its role might give some insight into [13] for a full pedigree diagram and more details.)…”

Section: Box 3 Fox Transcription Factors: Regulating Complexitymentioning

confidence: 99%

“…possible functions of FOXP2. When PAX6 is artificially expressed in the antenna of a fruit-fly, the fly grows an extra eye right there, at that rather unusual location [25]; for this reason, Walter Gehring has described it as a 'master control gene' [23]. PAX6 by itself does not actually contain a blueprint or plan for eye-building.…”

Section: Box 3 Fox Transcription Factors: Regulating Complexitymentioning

confidence: 99%

FOXP2 in focus: what can genes tell us about speech and language?

Marcus

Fisher

2003

Trends in Cognitive Sciences

171

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The human capacity for acquiring speech and language must derive, at least in part, from the genome. In 2001, a study described the first case of a gene, FOXP2, which is thought to be implicated in our ability to acquire spoken language. In the present article, we discuss how this gene was discovered, what it might do, how it relates to other genes, and what it could tell us about the nature of speech and language development. We explain how FOXP2 could, without being specific to the brain or to our own species, still provide an invaluable entry-point into understanding the genetic cascades and neural pathways that contribute to our capacity for speech and language.

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“…1 The predominant role of Pax6 even in different animal phyla such as insects and vertebrates is demonstrated by the high rate of conservation of Pax6 domains throughout evolution, as demonstrated by a 93% homology of the PAX6 amino acid sequence between Drosophila and human over the paired domain and the homeodomain. 2 In humans, Pax6 has been mapped to chromosome 11p13 and is expressed mainly in the eye, brain, and pancreas during development.…”

Section: Introductionmentioning

confidence: 99%

Continuous expression of the homeobox gene Pax6 in the ageing human retina

Stanescu

Iseli

Kerstin

et al. 2005

Eye

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Purpose In the past few years, the essential role of the homeobox gene Pax6 for eye development has been demonstrated unambiguously in a variety of species including humans. In humans, Pax6 mutations lead to a variety of ocular malformations of the anterior and posterior segment. However, little is known about PAX6 expression in the adult human retina. We have therefore investigated PAX6 levels and localization in the human retina at various ages. Methods Adult human eyes of various ages (17-79 years) were obtained from the Zurich Eye Bank. PAX6 expression levels and patterns were analysed by Western blot analysis of total retinal protein and by immunohistochemistry on paraffin sections, respectively. Results PAX6 expression in the retina was detected up to 79 years of donor age and was predominantly localized to the ganglion cell layer and the inner part of the inner nuclear layer. Conclusions PAX6 remains distinctly expressed throughout the lifespan of the human retina suggesting a role for PAX6 in the retina after completion of eye morphogenesis. Eye (2007) 21, 90-93.

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Pax 6: mastering eye morphogenesis and eye evolution

Cited by 684 publications

References 37 publications

Generation of structures formed by lens and retinal cells differentiating from embryonic stem cells

Generation of structures formed by lens and retinal cells differentiating from embryonic stem cells

FOXP2 in focus: what can genes tell us about speech and language?

Continuous expression of the homeobox gene Pax6 in the ageing human retina

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