Pb2154: Tp53 Gene Mutation Diversity in Russian Patients With B-Cell Lymphomas

Abstract

Background: Background: The TP53 gene plays a key role in cell cycle control, DNA repair, initiation of apoptosis, and other critical cellular processes. Mutations of this gene are found in almost all types of malignant neoplasms and the vast majority of cases are associated with poor prognosis. Among hematological malignancies, TP53 gene lesions are most actively studied in CLL, while for other lymphomas fewer data are available so far.