PCB and dioxin levels in plasma and human milk of 418 dutch women and their infants. Predictive value of PCB congener levels in maternal plasma for fetal and infant's exposure to PCBs and dioxins

Koopman-Esseboom, Corine; Huisman, Martijn; Weisglas‐Kuperus, Nynke; Vanderpaauw, Cg; Tuinstra, L.G.M.T.; Boersma, E. R.; Sauer, P. J. J.

doi:10.1016/0045-6535(94)90428-6

Cited by 112 publications

(71 citation statements)

References 13 publications

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“…Associations described previously among ΣPCBs and specific PCB congeners were confirmed in these analyses (De Voto et al 1997;Koopman-Esseboom et al 1994). Strong correlations were observed between ΣPCBs with PCB congeners 153 and 138, and with the three groupings of PCBs (r > 0.9, p-values < 0.0001).…”

Section: Resultssupporting

confidence: 61%

The relationship between human semen parameters and environmental exposure to polychlorinated biphenyls and p,p'-DDE.

Hauser

Chen

Pothier

et al. 2003

Environ Health Perspect

177

132

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Scientific and public concern exists about potential reproductive health effects of persistent chlorinated organic chemicals, such as polychlorinated biphenyls (PCBs), dichlorodiphenyltrichloroethane (DDT), and dichlorodiphenyldichloroethylene (DDE, the most stable daughter compound of DDT). To explore the hypothesis that environmental exposures to PCBs and DDE are associated with altered semen parameters, we conducted a cross-sectional study of 212 male partners of subfertile couples who presented to the Massachusetts General Hospital Andrology Laboratory. Semen parameters were analyzed as both a continuous measure and dichotomized based on World Health Organization reference values for sperm concentration (< 20 million/mL), motility (< 50% motile), and Kruger strict criteria for morphology (< 4% normal). The comparison group for the dichotomized analysis was men with all three semen parameters above the reference values. In serum, 57 PCB congeners and p,p -DDE were measured by congener-specific analysis using gas chromatography with electron capture detection. There were dose-response relationships among PCB-138 and sperm motility (odds ratio per tertile, adjusted for age, abstinence, and smoking, and p-value for trend were, respectively, 1.00, 1.68, 2.35, and p-value = 0.03) and morphology (1.00, 1.36, 2.53, p-value = 0.04). There was limited evidence of an inverse relationship between sum of PCBs, as well as those PCBs classified as cytochrome P450 enzyme inducers, with sperm motility and sperm morphology, as well as limited evidence of an inverse association between p,p -DDE and sperm motility. The lack of a consistent relationship among semen parameters and other individual PCB congeners and groupings of congeners may indicate a difference in spermatotoxicity between congeners.

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Section: Resultssupporting

confidence: 61%

The relationship between human semen parameters and environmental exposure to polychlorinated biphenyls and p,p'-DDE.

Hauser

Chen

Pothier

et al. 2003

Environ Health Perspect

177

132

View full text Add to dashboard Cite

show abstract

“…The total cord serum concentration of PCBs averaged 0.54 ng/g, with a median of 0.38 ng/g. The concentrations of key individual congeners (PCBs 118, 138, 153, and 180) were about one-half the concentrations reported in the Dutch cohort (Koopman-Esseboom et al 1994a). The levels in the New Bedford cohort are, however, quite similar to those reported in the Oswego, New York, fish-exposure cohort.…”

Section: The New Bedford Cohortmentioning

confidence: 51%

“…As Koopman-Esseboom et al (1994a) have shown, the levels of the various PCB and PCDD/PCDF congeners in human tissues are highly intercorrelated. This will undoubtedly complicate any attempts to determine structure-activity relationships based on human data.…”

mentioning

confidence: 99%

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Effects of PCB exposure on neuropsychological function in children.

Schantz

Widholm

Rice

2003

Environ Health Perspect

454

294

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In the last decade advances in the analytic methods for quantification of polychlorinated biphenyls (PCBs) have resulted in widespread availability of congener-specific analysis procedures, and large amounts of data on PCB congener profiles in soil, air, water, sediments, foodstuffs, and human tissues have become available. These data have revealed that the PCB residues in environmental media and human tissues may not closely resemble any of the commercial PCB mixtures, depending on source of exposure, bioaccumulation through the food chain, and weathering of PCBs in the environment. At the same time, toxicological research has led to a growing awareness that different classes of PCB congeners have different profiles of toxicity. These advances in analytic techniques and toxicological knowledge are beginning to influence the risk assessment process. As the data from ongoing PCB studies assessing the mediators of neurobehavioral outcomes in children are published, the weight of evidence for PCB effects on neurodevelopment is growing. Studies in Taiwan, Michigan (USA), New York (USA), Holland, Germany, and the Faroe Islands have all reported negative associations between prenatal PCB exposure and measures of cognitive functioning in infancy or childhood. The German study also reported a negative association between postnatal PCB exposure and cognitive function in early childhood--a result that had not been found in previous studies. Only one published study in North Carolina (USA) has failed to find an association between PCB exposure and cognitive outcomes. Despite the fact that several more recent studies have used congener-specific analytic techniques, there have been only limited attempts to assess the role of specific PCB congeners or classes of congeners in mediating neurodevelopmental outcomes. From a statistical standpoint, attempts to determine the role of individual congeners in mediating outcomes are hampered by the fact that concentrations of most individual congeners are highly correlated with each other and with total PCBs. From a toxicological standpoint, these efforts are hampered by the fact that many of the PCB congeners present in human tissues have never been studied in the laboratory, and their relative potency to produce nervous system effects is unknown. More complete information on the health effects of various congeners or congener classes would allow more informed scientific and risk assessment decisions.

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“…Hence, numerous studies have tried to develop a more costefficient assessment of dioxin exposure. Most studies have adopted the use of PCB congeners in breast milk as markers for dioxin measurement (Glynn et al, 2001;Koopman-Essebom et al, 1994). However, the association between concentrations of PCB markers and dioxin may vary among individual study populations with different geographical and cultural backgrounds.…”

Section: Introductionmentioning

confidence: 99%

Dioxin-like components in human breast milk collected from Hong Kong and Guangzhou

Lai¹,

Li²,

Xu³

et al. 2004

Environmental Research

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PCB and dioxin levels in plasma and human milk of 418 dutch women and their infants. Predictive value of PCB congener levels in maternal plasma for fetal and infant's exposure to PCBs and dioxins

Cited by 112 publications

References 13 publications

The relationship between human semen parameters and environmental exposure to polychlorinated biphenyls and p,p'-DDE.

The relationship between human semen parameters and environmental exposure to polychlorinated biphenyls and p,p'-DDE.

Effects of PCB exposure on neuropsychological function in children.

Dioxin-like components in human breast milk collected from Hong Kong and Guangzhou

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