PCDD/F and PCB in human serum of differently exposed population groups of an Italian city

Turrio-Baldassarri, Luigi; Abate, Vittorio; Battistelli, Chiara Laura; Carasi, Sergio; Casella, Marialuisa; Iacovella, Nicola; Indelicato, A.; Rocca, Cinzia La; Scarcella, Carmelo; Alivernini, Silvia

doi:10.1016/j.chemosphere.2008.01.081

Cited by 47 publications

(24 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As such, they may be measured as circulating hydroxyPCBs or as conjugated products excreted through the biliary route; on the global, they account for a minute fraction of body fat PCBs. 58 The median concentrations of PCB 138 (Pavia) and 153 (Milan) reported in our study are within the lower and upper median concentrations reported in 2005 by Apostoli et al 17 and comparable with those reported by Turrio-Baldassarri et al 26 in 2008. In Milan, PCB138 concentration was higher than those reported in these studies.…”

Section: Discussionsupporting

confidence: 92%

Exposure to priority organochlorine contaminants in the Italian general population. Part 2

et al. 2013

View full text Add to dashboard Cite

Concentrations of 36 polychlorinated biphenyl (PCB) congeners were measured in serum of 372 Italian residents of general population living in Novafeltria, Pavia, and Milan. Total PCB level differed significantly between these sites ( p < 0.0001) with median concentrations of 836.50, 1354.57, and 2062.08 pmol/g lipid, respectively. However, there is no evidence for the difference in distribution of total PCB levels by genders. Total dioxin-like PCBs differed significantly ( p < 0.0001) between the sites (median 109.78, 50.88, and 166.99 pmol/g lipid, respectively) and genders of Novafeltria and Pavia ( p = 0.011 and 0.009, respectively). PCB 138, 153, 170, and 180 differed significantly between the places of residence ( p < 0.0001) with higher values in Milan population. In the overall population, total PCB and PCB 138, 153, 156, 170, and 180 correlated positively with age (correlations range between 0.320 and 0.569, p < 0.0001). In Novafeltria, the correlations ranged between 0.545 and 0.670, and in Pavia, the correlations ranged between 0.516 and 0.666. In Milan, correlations with age range between 0.327 and 0.417 for total PCB and congeners 138, 153, and 180. With an exception of PCB 170, there was no evidence of significant difference in the distribution of most abundant PCB congeners and total PCB across the body mass index categories.

show abstract

Section: Discussionsupporting

confidence: 92%

Exposure to priority organochlorine contaminants in the Italian general population. Part 2

et al. 2013

View full text Add to dashboard Cite

show abstract

“…For PCB 153, one of the 4 congeners quantified in all 5 samples, the concentrations were in the range of what has been found in populations in Europe, Canada and Russia, as reviewed by Hofvander (2006). Previous studies have reported similar concentrations for PCB 28 but five times lower concentrations for PCB 52 (Cerna et al, 2008; Turrio-Baldassarri et al, 2008). Inoue et al (2006) reported ten time lower concentrations for PCB 74 and PCB 99.…”

Section: Model Evaluationmentioning

confidence: 62%

External exposure and bioaccumulation of PCBs in humans living in a contaminated urban environment

Norström

Czub

McLachlan

et al. 2010

Environment International

View full text Add to dashboard Cite

Humans are exposed to different mixtures of PCBs depending on the route of exposure. In this study we investigated the potential contribution of inhalation to the overall human exposure to PCBs in an urban area. For this purpose, the mechanistically based, non-steady state bioaccumulation model ACC-HUMAN was applied to predict the PCB body burden in an adult living in the Midwestern United States who eats a typical North American diet and inhales air contaminated with PCBs. Dietary exposure was estimated using measured data for eighteen PCB congeners in different food groups (fish, meat and egg, dairy products). Two scenarios for inhalation exposure were evaluated: one using air concentrations measured in Chicago, and a second using air measurements in a remote area on Lake Michigan, Sleeping Bear Dunes. The model predicted that exposure via inhalation increases the accumulated mass of PCBs in the body by up to thirty percent for lower chlorinated congeners, while diet is by far the dominant source of exposure for those PCB congeners that accumulate most in humans.

show abstract

“…PCDDs and PCDFs, but not TCDD, were also found, although the DL-PCBs contributed to the overall toxicity equivalent (TEQ) substantially, sometimes outweighing the contribution of PCDD/Fs. 17,18 …”

Section: Discussionmentioning

confidence: 99%

“…15,16 Other POPs, including polychlorinated dibenzo-para-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs), have also been found in the environment, animal-derived food (meat, eggs, milk and dairy products) and human sera, with a high correlation with PCB levels. 17,18 The aim of this study was to assess the association between PCB serum levels and glycaemia and diabetes in people living in this town.…”

Section: Introductionmentioning

confidence: 99%

Polychlorinated Biphenyls, Glycaemia and Diabetes in a Population Living in a Highly Polychlorinated Biphenyls-Polluted Area in Northern Italy: A Cross-Sectional and Cohort Study

Zani

Donato

Magoni³

et al. 2013

Journal of Public Health Research

Self Cite

View full text Add to dashboard Cite

Conflicts of interests: the authors declare no potential conflict of interests.BackgroundPolychlorinated biphenyls (PCBs) have been found to be associated with diabetes in some, but not all, studies performed so far. The aim of this study was to assess the association between PCB serum levels and glycaemia and diabetes in people living in Brescia, a highly industrialised PCB-polluted town in Northern Italy.Design and Methods527 subjects were enrolled in a cross-sectional population-based study: they were interviewed face-to-face in 2003 and also provided a blood sample under fasting conditions. The concentration of 24 PCB congeners was determined using gas-chromatography (GC/MS). Subsequently, all subjects were included in a follow-up (cohort) study. According to the Local Health Authority health-care database, subjects were considered to be diabetic if they had diabetes at interview time (prevalent cases) or during a 7-year follow-up (incident cases).ResultsA total of 53 subjects (10.0%) were diabetics: 28 had diabetes at enrolment and other 25 developed the disease subsequently. Diabetes frequency increased according to the serum concentrations of total PCBs and single PCB congeners, but no association was found when estimates were adjusted for education, body mass index, age and gender by logistic regression analysis. Accordingly, glycaemia increased with PCB serum levels, but no association was observed when multiple regression analysis, including confounding factors, was performed.ConclusionsThis study does not support the hypothesis that PCB environmental exposure is strictly associated with diabetes or glycaemia.

show abstract

PCDD/F and PCB in human serum of differently exposed population groups of an Italian city

Cited by 47 publications

References 27 publications

Exposure to priority organochlorine contaminants in the Italian general population. Part 2

Exposure to priority organochlorine contaminants in the Italian general population. Part 2

External exposure and bioaccumulation of PCBs in humans living in a contaminated urban environment

Polychlorinated Biphenyls, Glycaemia and Diabetes in a Population Living in a Highly Polychlorinated Biphenyls-Polluted Area in Northern Italy: A Cross-Sectional and Cohort Study

Contact Info

Product

Resources

About