PCL microsphere/PEG‐based composite hydrogels for sustained release of methadone hydrochloride

Abstract

Hydrogels have increasingly received considerable attention for local opioids delivery in order to sustained wound pain relief. However, burst release of drugs is a critical problem of hydrogels. To this aim, a local drug delivery system consisting of polycaprolactone (PCL) microspheres containing methadone hydrochloride/polyethylene glycol (PEG)-based hydrogels were developed to prolong drug release with potential utilization in pain treatment. Four different drug delivery systems, including methadone hydrochloride/PEG-(N 3 ) 4 -based hydrogel, methadone hydrochloride/PEG-(N 3 ) 2 -based hydrogel, methadone hydrochloride/PCL/PEG-(N 3 ) 4 , and methadone hydrochloride/PCL/PEG-(N 3 ) 2 composite hydrogels, were fabricated to investigate drug release profiles of these systems. The results showed that drug released can be controlled by both the double-barrier matrix (hydrogel/microsphere), and the crosslinking density of hydrogels. Therefore, methadone hydrochloride/PCL/PEG-(N 3 ) 2 composite hydrogel with high crosslinking density has great potential application in sustained release systems for wound pain relief.

Mechanical properties of cell- and microgel bead-laden oxidized alginate-gelatin hydrogels

“…Efforts have been made to engineer polymer microspheres for controlled drug release, [117][118][119][120] as well as to incorporate polymer microspheres as drug delivery vesicles into hydrogels. [121][122][123] Multi-phasic "gel-in-gel" materials have been recently discussed and are currently explored for tissue engineering applications. 124 We used PAAm hydrogel microgel beads with a diameter of approx.…”

Control Release Coating for Urinary Catheters with Enhanced Released Profile for Sustained Antimicrobial Protection

“…While it is important to be able to release a high percentage of biocides upon stimulus, an ideal and optimal antimicrobial coating should also possess an elution profile that is sustainable over a prolonged period . Addition of hydrophilic PEG components has been demonstrated in several studies to enhance the elution sustainability from polymers ,− ,− In this study, three different types of PEG additives were chosen: a PEG homopolymer (PEG 5k ) and two copolymers (PEG 5k - b -PCL 5k and PEG 5k - b -PCL 13k ). The compositions of the various coatings with PEG homopolymer and copolymers formulated for each study are listed in Table and Table respectively.…”

An Overview on Recent Progress of the Hydrogels: From Material Resources, Properties, to Functional Applications

“…Composite hydrogels for drug delivery [116] Clickable PEG hydrogel microspheres as building blocks for 3D bioprinting Three-dimensional bio-printing [117] HA PEG/HA hybrid hydrogels for biologically and mechanically tailorable bone marrow organoids…”