PD-0299: Changes in PET/CT uptake between pre/ and post-treatment might predict response in esophageal cancer

Jimenez-Jimenez, E.; Ortiz, Irene; Aymar, N.; Roncero, R.; Hernando-Pérez, Mercedes; Arregui, Elena; Gómez, Mario; Rodriguez, S.; Lozano, Eloisa Bayo

doi:10.1016/s0167-8140(21)00323-6

Cited by 2 publications

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“…Several risk factors associated with tumor relapse following esophagectomy have been defined, such as poor pathological response to nCRT, positive pathological lymph node status, and lymphovascular space invasion (LVSI) [10][11][12]. The maximum standard uptake value (SUVmax) and the ratio of change in SUV (ΔSUV ratio) of F-18-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 FDG-PET/CT) have also been reported to be useful in predicting the prognosis of EC patients treated with nCRT and subsequent esophagectomy [13,14].…”

Section: Introductionmentioning

confidence: 99%

Prognostic factors associated with 18FDG-PET/CT in esophageal squamous cell carcinoma after trimodality treatment

et al. 2022

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Purpose This study aimed to determine the pathological complete response (pCR), overall survival (OS), and disease-free survival (DFS) in patients with locally advanced esophageal squamous cell carcinoma (ESCC) using post-neoadjuvant chemoradiotherapy (nCRT) F-18-fluorodeoxyglucose (18FDG). Methods This is a retrospective study of patients with locally advanced ESCC receiving nCRT and then esophagectomy between January 2011 and December 2018 in the Tri-Service General Hospital, Taipei, Taiwan. A total of 50 patients were enrolled in the study. Survival analysis was performed using the Kaplan–Meier method and Cox proportional hazards model. Univariate and multivariate analysis were used to determine the independent prognostic factors. Results Fifty patients were enrolled in the study, and 18 had pathological complete response. Post-nCRT SUVmax ≥ 3 is a poor prognostic factor associated with overall survival (HR: 3.665, P = 0.013) and disease-free survival (HR: 3.417, P = 0.011). Poor prognosis was found in the non-pCR plus post-nCRT SUVmax ≥ 3 group compared with pCR plus post-nCRT SUVmax < 3 group. Conclusions SUVmax ≥ 3 is a poor prognostic factor in esophageal squamous cell carcinoma after trimodality treatment, even in patients having pathological complete response.

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Section: Introductionmentioning

confidence: 99%

Prognostic factors associated with 18FDG-PET/CT in esophageal squamous cell carcinoma after trimodality treatment

et al. 2022

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“…Several risk factors associated with disease progression after esophagectomy have been de ned: poor pathological response to nCRT, positive pathological lymph nodes status, and the presence of lymphovascular space invasion (LVSI) (van Hagen et al 2013; Smit et al 2013; Lagarde et al 2015). Maximum standard uptake value (SUVmax) and the ratio of change in SUV (ΔSUV ratio) of F-18-uorodeoxyglucose positron emission tomography to computed tomography ( 18 FDG-PET/CT) were also reported to be useful in predicting prognosis after trimodal treatment (Lee et al 2021;Jimenez-Jimenez et al 2020).…”

Section: Introductionmentioning

confidence: 99%

250. Prognostic Factors Associated With 18fdg-Pet/Ct in Esophageal Squamous Cell Carcinoma After Trimodality Treatment

Feng

Chen

Kuo

et al. 2022

Diseases of the Esophagus

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Patients with locally advanced and potentially curable esophageal cancer (EC) should receive trimodality treatment, which involves neoadjuvant concurrent chemoradiotherapy (nCRT) followed by esophagectomy. The maximum standard uptake value (SUVmax) in SUV of 18FDG-PET/CT have been reported to be useful in predicting the prognosis of EC patients treated with nCRT and subsequent esophagectomy. We aimed to determine the pathological response in patients with EC after trimodality therapy and to investigate the prognostic factors associated with SUVmax. This was a retrospective study of patients with locally advanced esophageal squamous cell carcinoma who received nCRT followed by esophagectomy between January 2011 and December 2018 at the Tri-Service General Hospital in Taipei, Taiwan. Survival analysis was performed using the Kaplan–Meier method and the Cox proportional hazards model. Univariate and multivariate analyses were used to determine the independent prognostic factors. A total of 79 patients with esophageal cancer underwent esophagectomy, and 50 of them were enrolled in the study. Among the 50 patients enrolled, 18 had a pCR. A post-nCRT maximum standard uptake value (SUVmax) ≥ 3 was a poor prognostic factor associated with OS (hazard ratio [HR]: 3.665, P = 0.013) and PFS (HR: 3.417, P = 0.011). Poor prognosis was found in patients with pCR and a post-nCRT SUVmax ≥3 as compared with those with pathological partial response and a post-nCRT SUVmax <3. SUVmax ≥3 is a poor prognostic factor in ESCC after trimodality treatment, even in patients with pCR.

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PD-0299: Changes in PET/CT uptake between pre/ and post-treatment might predict response in esophageal cancer

Cited by 2 publications

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Prognostic factors associated with 18FDG-PET/CT in esophageal squamous cell carcinoma after trimodality treatment

Prognostic factors associated with 18FDG-PET/CT in esophageal squamous cell carcinoma after trimodality treatment

250. Prognostic Factors Associated With 18fdg-Pet/Ct in Esophageal Squamous Cell Carcinoma After Trimodality Treatment

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