Pd‐Catalyzed Mizoroki‐Heck Annulation and Equivalent Aminocarbonylation Reactions Enabled by Mo(CO)₆‐Mediated Direct Reduction of Nitro Derivatives

Abstract

A Pd-catalyzed Mizoroki-Heck annulation/equivalent aminocarbonylation reaction of alkene-tethered aryl iodides with nitro compounds is accomplished, providing facile access to diverse carbamoyl-substituted benzoheterocycles, such as indolin-2-ones and 2,3-dihydrobenzofurans, in moderate to good yields. The cost-effective Mo(CO) 6 complex is discovered to be a solid carbonyl (CO) source and an ideal reducing agent, enabling the efficient production of the desired benzoheterocycles with broad substrate scope tolerance, including both nitroarenes and nitroalkanes under external reductant-free conditions.