Pd(II)/PhI(OAc)2 promoted direct cross coupling of glucals with aromatic acids

Advances in Pd-catalyzed C–C bond formation in carbohydrates and their applications in the synthesis of natural products and medicinally relevant molecules

“…In 2009, Zubeda Begum et al 109 demonstrated the C -2 functionalization of glycals through oxidative cross-coupling with an aromatic carboxylic acid. In this approach, when tri- O -acetyl- d -glucal 207 reacted with aromatic acids 217 in the presence of Pd(OAc) 2 and PhI(OAc) 2 , C 2-acyloxyglycals 218 were formed and the synthesized compounds were further utilized for biologically active natural product synthesis ( Scheme 55 ).…”