Pd08-03 eau BCR Risk Classification as Decision Tool for Salvage Radiotherapy? A Multicenter Study

Abstract

and two patients underwent incision of bladder neck contracture, all !2 years post-RP. Mean EPIC urinary incontinence scores at baseline, post-SBRT/pre-RP, 3 months, and 24 months post-RP were 90 (82-99), 91 (84-97), 14 (5-22), and 42 (17-68), respectively. No patients reported using pads pre-RP, while 92% and 75% used at least one pad per day at per day at 12 months and 24 months post-RP. Half of men had baseline erections suitable for intercourse which decreased to 0% post-RP and remained 0% to 24 months post-RP. SBRT resulted in negative surgical margins in 100% of patients, but biochemical recurrence occurred in seven patients (43%).CONCLUSIONS: Despite high radiographic and pathologic response, neoadjuvant SBRT to 30-35 Gy in 5 fractions followed by RP results in unacceptably high toxicity, severe QoL declines, and high recurrence rates. Our results highlight the importance of systemic therapy in the management of locally advanced prostate cancer. Ongoing trials of definitive SBRT and systemic therapy without RP are ongoing (NCT04194554).