2023
DOI: 10.3390/cancers15225308
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PDE3A Is a Highly Expressed Therapy Target in Myxoid Liposarcoma

Kirsi Toivanen,
Sami Kilpinen,
Kalle Ojala
et al.

Abstract: Liposarcomas (LPSs) are a heterogeneous group of malignancies that arise from adipose tissue. Although LPSs are among the most common soft-tissue sarcoma subtypes, precision medicine treatments are not currently available. To discover LPS-subtype-specific therapy targets, we investigated RNA sequenced transcriptomes of 131 clinical LPS tissue samples and compared the data with a transcriptome database that contained 20,218 samples from 95 healthy tissues and 106 cancerous tissue types. The identified genes wer… Show more

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