2022 Help me understand this report
PDE5A: Key Enzyme to Overcome Platelet Inhibition
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2024
2024
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“…The study revealed that diminished VWF synthesis/secretion and increased VWF clearance play contributing roles. 83 Importantly, Bourne et al 84 alerted to CLEC-2's distinct role in mouse and human platelets. While CLEC-2 is vital for thrombus growth in mice, it appeared to be less crucial for human platelet thrombus formation under arterial shear, raising key questions about CLEC-2's biological role in mice versus humans.…”
Section: Getting To the Heart Of The Mattermentioning
confidence: 99%
“…The study revealed that diminished VWF synthesis/secretion and increased VWF clearance play contributing roles. 83 Importantly, Bourne et al 84 alerted to CLEC-2's distinct role in mouse and human platelets. While CLEC-2 is vital for thrombus growth in mice, it appeared to be less crucial for human platelet thrombus formation under arterial shear, raising key questions about CLEC-2's biological role in mice versus humans.…”
Section: Getting To the Heart Of The Mattermentioning
confidence: 99%
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