PDGFRA (platelet-derived growth factor receptor, alpha polypeptide)

Abstract

Review on PDGFRA, with data on DNA/RNA, on the protein encoded and where the gene is implicated.

t(4;10)(q12;q23) PDGFRA/TNKS2

“…Functions as homo-and/or heterodimers depending on the cell type; activated by ligand-induced dimerization and autophosphorylation. Subsequent phosphorylation of its substrates initiates a variety of signal transduction cascades that promotes cell proliferation, survival and migration through the PI3K-AKT-mTOR and RAS-MAPK pathways as well as promotes activation of STAT family members (JAK/STAT) (Zamecnikova and Bahar, 2015).…”