PDT‐induced HSP70 externalization up‐regulates NO production via TLR2 signal pathway in macrophages

Song, Sheng; Zhou, Feifan; Chen, Wei R.; Xing, Da

doi:10.1016/j.febslet.2012.11.026

Cited by 26 publications

(23 citation statements)

References 29 publications

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“…In this study we demonstrated a positive correlation between the concentrations of Hsp70 and NO in the tissues examined, especially in benign tumours and grade I and grade II malignant tumours, which may indicate an interdependence of Hsp70 and nitrite ion production in canine mammary gland tumours. This is consistent with the findings of a recent study by Song et al (2013) who showed that apoptotic cells overexpressing Hsp70 induced a marked NO production in macrophages. This suggests that Hsp70 plays an important role both in the up-regulation of NO production and in the host's anti-tumour immunity.…”

Section: Discussionsupporting

confidence: 93%

Heat shock protein 70 and nitric oxide concentrations in non-tumorous and neoplastic canine mammary tissues: preliminary results – Short communication

Szczubiał

Urban‐Chmiel

Łopuszyński

2015

Acta Veterinaria Hungarica

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The concentrations of heat shock protein 70 (Hsp70) and nitric oxide ions (NO), measured as nitrite, were determined in canine mammary tumours and nontumorous mammary gland tissues. The concentrations of Hsp70 and NO were significantly higher in both benign and malignant tumours than in non-tumorous mammary tissues. Hsp70 concentration decreased with the increase in the grade of histological malignancy. A strong positive correlation was found between the concentrations of Hsp70 and NO in the benign tumours as well as in grade I and grade II malignant tumours. The results indicate that the process of neoplastic transformation in the canine mammary gland is related to a significant increase in Hsp70 and NO concentration in tumour tissues, and an interdependence between Hsp70 and nitrite ion production can be observed.

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Section: Discussionsupporting

confidence: 93%

Heat shock protein 70 and nitric oxide concentrations in non-tumorous and neoplastic canine mammary tissues: preliminary results – Short communication

Szczubiał

Urban‐Chmiel

Łopuszyński

2015

Acta Veterinaria Hungarica

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“…The enhancement in angiogenic markers (NO, VEGF-A) observed in diabetic mice in response to PDT (Figs. 1a and 2a), could occur due to increase iNOS [28][29][30], release of protein-bound NO [31], and activation of hypoxia inducible factor VEGF signaling pathway [27]. However, these responses were reversed at the high APDT fluence, possibly due to the higher oxidative stress-induced damage to inflammatory cells [32].…”

Section: Discussionmentioning

confidence: 99%

Topical antimicrobial photodynamic therapy improves angiogenesis in wounds of diabetic mice

et al. 2015

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We report the results of our investigations on the effect of antimicrobial photodynamic therapy (APDT) on angiogenesis in wounds of diabetic mice. For this, measurements were made on levels of nitric oxide (NO), vascular endothelial growth factor-A (VEGF-A), and markers of proinflammatory stress (phosphorylated nuclear factor kappa B and p(38) mitogen-activated protein kinase) on day 3 post-wounding. For uninfected and infected wounds, the levels of NO, VEGF-A were lower and the levels of phospho-NF-kB-p65, phospho-p(38)MAPK were higher in diabetic mice compared with that in nondiabetic mice. For infected wounds, multiple APDT (fluence ~60 J/cm(2)) led to increase in NO, VEGF-A levels and a decrease in the phospho-NF-kB-p65, phospho-p(38)MAPK. Further, compared with aminoguanidine, and silver nitrate, multiple APDT was observed to result in a much improved proangiogenic response.

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“…39 The role of ecto-HSP70 in ICD has not been strongly elucidated; however, at least in the case of PDT 11,22 ecto-HSP70 might favour nitric oxide (NO) production from innate immune cells. 7,22,40 In terms of capacity to mediate phagocytosis of dying cells by acting as an 'eat me' signal; an in silico analysis revealed that CRT harbours close homologues of crucial phagocytosis-assisting motifs, whereas HSP70/90 did not. 22 In agreement, the presence of ecto-CRT correlates better with increased phagocytosis of dying cancer cells than either ecto-HSP70/90.…”

Section: Viral Response and Icd: A New Connection?mentioning

confidence: 99%

Danger signalling during cancer cell death: origins, plasticity and regulation

et al. 2013

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Accumulating data indicates that following anti-cancer treatments, cancer cell death can be perceived as immunogenic or tolerogenic by the immune system. The former is made possible due to the ability of certain anti-cancer modalities to induce immunogenic cell death (ICD) that is associated with the emission of damage-associated molecular patterns (DAMPs), which assist in unlocking a sequence of events leading to the development of anti-tumour immunity. In response to ICD inducers, activation of endoplasmic reticulum (ER) stress has been identified to be indispensable to confer the immunogenic character of cancer cell death, due to its ability to coordinate the danger signalling pathways responsible for the trafficking of vital DAMPs and subsequent anti-cancer immune responses. However, in recent times, certain processes apart from ER stress have emerged (e.g., autophagy and possibly viral response-like signature), which have the ability to influence danger signalling. In this review, we discuss the molecular nature, emerging plasticity in the danger signalling mechanisms and immunological impact of known DAMPs in the context of immunogenic cancer cell death. We also discuss key effector mechanisms modulating the interface between dying cancer cells and the immune cells, which we believe are crucial for the therapeutic relevance of ICD in the context of human cancers, and also discuss the influence of experimental conditions and animal models on these. The ultimate outcome of an immune response to cancer cell death (i.e., anti-tumourigenic, pro-tumourigenic or autoimmunity or different combinations of these) tends to be complex and may depend on a number of factors like the type of the cancer cells that die and their in vivo location, the type of cell death pathway they follow to die, the types of immune cells that phagocytose them or interact with them and, last but not the least, whether a cancer antigen is recognized or not. Tolerogenicity towards cell death, as happens predominantly when cancer cells undergo physiological apoptosis (after treatment with most anti-cancer therapies), depends on a number of factors including the presence of immunosuppressive factors, absence or inactivation of DAMPs, induction of tolerogenic dendritic cells (DCs), 'suboptimal' activation of CD8 þ T cells only and apoptotic 'mimicry'.Accentuated immunogenicity exhibited by cancer cells undergoing immunogenic cell death (ICD; after treatment with selected anti-cancer therapies), depends on a number of factors like emission of DAMPs (i.e., surface exposure of certain chaperones, secretion or release of certain nucleotides and endokines), presence of immunostimulatory factors, induction of DC maturation (both phenotypic and functional) and optimal activation of CD4 þ ab, CD8 þ ab and gd T-cell responses. Certain DAMPs are actively trafficked during ICD by danger signalling pathways, which are instigated and regulated by a complex interplay between endoplasmic reticulum (ER) stress, reactive oxygen species (ROS) production and cert...

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PDT‐induced HSP70 externalization up‐regulates NO production via TLR2 signal pathway in macrophages

Cited by 26 publications

References 29 publications

Heat shock protein 70 and nitric oxide concentrations in non-tumorous and neoplastic canine mammary tissues: preliminary results – Short communication

Heat shock protein 70 and nitric oxide concentrations in non-tumorous and neoplastic canine mammary tissues: preliminary results – Short communication

Topical antimicrobial photodynamic therapy improves angiogenesis in wounds of diabetic mice

Danger signalling during cancer cell death: origins, plasticity and regulation

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