Peak Parking-Moment Analysis Method for the Measurement of Surface Diffusion Coefficients

Miyabe, Kanji; Matsumoto, Yuko; Ando, Nobuho

doi:10.2116/analsci.25.211

Cited by 17 publications

(8 citation statements)

References 29 publications

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“…It seems that both of them represent the same flux of sample molecules in the stationary phase although they respectively correspond to axial dispersion and intraparticle surface diffusion. In previous papers (27)(28)(29), it has been experimentally demonstrated that D Ls is equal to D s .…”

Section: Discussionmentioning

confidence: 97%

“…A brief explanation about the kinetic data analysis procedure of the PP-MA method is provided in the following. More detailed information can be found in other literature (27)(28)(29).…”

Section: Discussionmentioning

confidence: 99%

“…The arrested flow or stopped flow method has been used for some kinetic properties in various GC and LC systems (20)(21)(22)(23)(24)(25). Recently, the PP-MA method has also been applied to the kinetic study on the mass transfer in RPLC systems using C 18 -silica monolithic columns and conventional columns packed with full-porous C 18 -silica spherical particles (26)(27)(28)(29). The information about intraparticulate mass transfer kinetics can be derived from the band broadening due to axial diffusion during the interruption period.…”

Section: Introductionmentioning

confidence: 99%

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Surface Diffusion in C18-Silica Monolithic Stationary Phase

Miyabe

2009

Journal of Chromatographic Science

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A peak parking-moment analysis method was used for the measurement of surface diffusion coefficient (D(s)) in a reversed-phase liquid chromatography (RPLC) system consisting of a C(18)-silica monolithic column and a mixture of methanol and water (70/30, v/v). The D(s) values experimentally measured were analyzed by considering the correlation with corresponding values of molecular diffusivity (D(m)) and the retention equilibrium constant (K(a)). It seems that the correlation between D(s)/D(m) and K(a) is represented by a single curve irrespective of the RPLC conditions of temperature and the type of sample compounds. The increase in K(a) is accompanied with the decrease in D(s)/D(m). Oppositely, the ratio of D(s)/D(m) increases and approaches around unity when K(a) infinitely decreases. It seems that surface diffusion is originally similar to molecular diffusion and that it is restricted due to the sample retention. These characteristics of surface diffusion are the same between the C(18)-silica monolithic stationary phase and the conventional C(18)-silica gel particles. In addition, the values of K(a) and D(s) are also comparable between them. It is concluded that basic properties concerning the retention equilibrium and surface diffusion of the C(18)-silica monolithic stationary phase are almost the same as those of the conventional C(18)-silica gel particles in spite of the difference between their structural characteristics.

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Section: Discussionmentioning

confidence: 97%

“…A brief explanation about the kinetic data analysis procedure of the PP-MA method is provided in the following. More detailed information can be found in other literature (27)(28)(29).…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Surface Diffusion in C18-Silica Monolithic Stationary Phase

Miyabe

2009

Journal of Chromatographic Science

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“…Peak-parking methods have been used previously for the measurement of diffusion coefficients in chromatographic systems [32,35,36,39,40,43,44]. Peak-parking experiments were carried out with the same columns as above and the Acquity UPLC.…”

Section: Methodsmentioning

confidence: 99%

Retention and effective diffusion of model metabolites on porous graphitic carbon

Lunn

Yun

Jorgenson

2017

Journal of Chromatography A

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The study of metabolites in biological samples is of high interest for a wide range of biological and pharmaceutical applications. Reversed phase liquid chromatography is a common technique used for the separation of metabolites, but it provides little retention for polar metabolites. An alternative to C18 bonded phases, porous graphitic carbon has the ability to provide significant retention for both non-polar and polar analytes. The goal of this work is to study the retention and effective diffusion properties of porous graphitic carbon, to see if it is suitable for the wide injection bands and long run times associated with long, packed capillary-scale separations. The retention of a set of standard metabolites was studied for both stationary phases over a wide range of mobile phase conditions. This data showed that porous graphitic carbon benefits from significantly increased retention (often >100 fold) under initial gradient conditions for these metabolites, suggesting much improved ability to focus a wide injection band at the column inlet. The effective diffusion properties of these columns were studied using peak-parking experiments with the standard metabolites under a wide range of retention conditions. Under the high retention conditions, which can be associated with retention after injection loading for gradient separations, D/D∼0.1 for both the C18-bonded and porous graphitic carbon columns. As C18 bonded particles are widely, and successfully utilized for long gradient separations without issue of increasing peak width from longitudinal diffusion, this suggests that porous graphitic carbon should be amenable for long runtime gradient separations as well.

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“…Several experimental techniques for determining D S have been proposed [9][10][11][12][13][14][15][16]. For a fixed-bed breakthrough curve, the most common technique used in industrial design is the mass transfer zone (MTZ) method [16][17][18][19] that can be applied to multicomponent systems.…”

Section: Introductionmentioning

confidence: 99%

A Simple Determination Method of Adsorption Kinetics from a Liquid Phase Fixed‐Bed Breakthrough Curve

et al. 2013

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The mass transfer zone (MTZ) method using the linear driving force (LDF) approximation is the most common and frequently used technique for the analysis of adsorption kinetics from a fixed-bed breakthrough curve and for adsorptive process design. However, the adsorption kinetics obtained by the MTZ method includes approximations and estimation errors. This report describes a new analytical method for determining the intraparticle diffusivity (D S ) and the fluid-film mass transfer coefficient (k F ) from an experimental breakthrough curve without using the LDF approximation and empirical correlations for estimating k F . The proposed method has the advantage of less trial and error on the curve-fitting process and helps better determine D S and k F . The estimation procedure of the Biot number that represents the ratio of D S to k F is the key of this method. The values of D S and k F for the adsorption of phenols onto activated carbon were determined from experimental breakthrough curves using the new analytical method. The results indicate that the method presented in this study yields reliable values.

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Peak Parking-Moment Analysis Method for the Measurement of Surface Diffusion Coefficients

Cited by 17 publications

References 29 publications

Surface Diffusion in C18-Silica Monolithic Stationary Phase

Surface Diffusion in C18-Silica Monolithic Stationary Phase

Retention and effective diffusion of model metabolites on porous graphitic carbon

A Simple Determination Method of Adsorption Kinetics from a Liquid Phase Fixed‐Bed Breakthrough Curve

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