Pear pomace water extract reduces adiposity in vivo and in vitro by activating the AMPK-dependent pathway

Background: Obesity is considered as a global epidemic worldwide. This disorder is associated to several health effects such as metabolic disturbances that need both prevention and treatment actions. In this sense, bioactive secondary metabolites can be obtained from cheap sources such as agro-industrial waste providing a sustainable alternative against obesity. Among these secondary metabolites, phenolic compounds present a common chemical structure core with different substitutions that provides them biological properties such as antioxidant, inflammatory, anti-aging capacities. Objective: Objective: The aim of this review is to compile anti-obesity therapeutic targets for phenolic compounds from agro-industrial byproducts. Method: Scientific information has been obtained from different databases such as Scopus, PubMed and Google Scholar in order to select the available full text studies in last years. Results: This review shows that peel, seed, pomace and other byproducts from agro-industry have different effects inhibiting enzymes related to lipid or glucose metabolism and modulating biomarkers, genes and gut microbiota in animal models. Conclusion: Revalorizing actions of agro-industrial byproducts in the prevention or treatment of obesity or associated disorders can be considered to develop new high value products that act on lipid, glucose and energy metabolisms, oxidative stress, inflammation, adipose tissue or gut microbiota. However, further human studies are need in order to stablish the optimal administration parameters.

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Therapeutic Targets for Phenolic Compounds from Agro-industrial By-products against Obesity

Cádiz-Gurrea

Fernández-Ochoa

Villegas-Aguilar

et al. 2022

CMC

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Pear pomace water extract reduces adiposity in vivo and in vitro by activating the AMPK-dependent pathway

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Therapeutic Targets for Phenolic Compounds from Agro-industrial By-products against Obesity

Therapeutic Targets for Phenolic Compounds from Agro-industrial By-products against Obesity

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