Pectin-enriched diet affects distribution and expression of apoptosis-cascade proteins in colonic crypts of dimethylhydrazine-treated rats.

Avivi-Green, Carmel; Madar, Zecharia; Schwartz, Betty

doi:10.3892/ijmm.6.6.689

Cited by 18 publications

(32 citation statements)

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“…Several studies have shown that pectin itself can suppress tumor and inhibit metastasis in animal studies (Heitman et al, 1992;Platt and Raz, 1992;Pienta et al, 1995;Nangia-Makker et al, 2002). Furthermore, pectin can also induce apoptosis in cancer cells (Jackson et al, 2007;Chang et al, 1997;Avivi-Green et al, 2000a;AviviGreen et al, 2000b;Kossoy et al, 2001;Olano-Martin et al, 2003;Chauhan et al, 2005). Here, we showed the IC50 of unconjugated pectin NP was up to 19 mg/ml.…”

Section: Discussionsupporting

confidence: 50%

Pectin nanoparticle enhances cytotoxicity of methotrexate against hepG2 cells

2012

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Section: Discussionsupporting

confidence: 50%

Pectin nanoparticle enhances cytotoxicity of methotrexate against hepG2 cells

2012

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“…We have shown that over-expression of galectin-3 protects cells from anoikis (Kim et al, 1999). Moreover, it was reported that rats fed on a 15% citrus pectin enriched diet showed a higher apoptotic index in their colon (Avivi- Green et al, 2000). In another study, treatment of human colonic adenocarcinoma cell line HT29 with dietary pectin and its degradation products (pectic ologisaccharides) resulted in reduced proliferation and increased caspase 3 activity and DNA laddering (Olano-Martin et al, 2003).…”

Section: Therapeutic Implicationsmentioning

confidence: 99%

Galectin-3 in apoptosis, a novel therapeutic target

Nangia‐Makker

Nakahara

Hogan

et al. 2007

J Bioenerg Biomembr

119

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During the past decade, extensive progress has been made toward understanding the molecular basis for the regulation of apoptosis. In mammalian cells undergoing apoptosis, two distinct mechanisms or pathways are operated and are triggered by cell death stimuli from intra-or extracellular environments, namely the intrinsic or extrinsic pathways, resulting in mitochondrial membrane depolarization. Several lines of evidence from our laboratories and others have indicated that galectin-3 plays an important role in these pathways by binding to various ligands. Here the authors provide a brief discussion on the role of endogenous or extra-cellular galectin-3 in the regulation of apoptosis and how it could be used as a therapeutic target using natural plant products as its functional inhibitors.

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“…The results are expressed as the fold increase of caspase activity in apoptotic cells relative to their respective controls. In background reactions, no DVEDp-NA substrate was added, and the values obtained were subtracted from experimental results before calculating the fold increase [24] .…”

Section: Caspase-3 Proteolytic Activitymentioning

confidence: 99%

Ameliorative effects of bombesin and neurotensin on trinitrobenzene sulphonic acid-induced colitis, oxidative damage and apoptosis in rats

Akçan¹,

Muhtaroğlu²,

Akgün³

et al. 2008

WJG

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AIM:To investigate the effects of bombesin (BBS) and neurotensin (NTS) on apoptosis and colitis in an ulcerative colitis model. METHODS:In this study, a total of 50 rats were divided equally into 5 groups. In the control group, no colitis induction or drug administration was performed. Colitis was induced in all other groups. Following the induction of colitis, BBS, NTS or both were applied to three groups of rats. The remaining group (colitis group) received no treatment. On the 11th d after induction of colitis and drug treatment, blood samples were collected for TNF-α and IL-6 level studies. Malondialdehyde (MDA), carbonyl, myeloperoxidase (MPO) and caspase-3 activities, as well as histopathological findings, evaluated in colonic tissues. R E S U LT S :A c c o r d i n g t o t h e m a c r o s c o p i c a n d microscopic findings, the study groups treated with BBS, NTS and BBS + NTS showed significantly lower damage and inflammation compared with the colitis group (macroscopic score, 2.1 ± 0.87, 3.7 ± 0.94 and 2.1 ± 0.87 vs 7.3 ± 0.94; microscopic score, 2.0 ± 0.66, 3.3 ± 0.82 and 1.8 ± 0.63 vs 5.2 ± 0.78, P < 0.01). TNF-α and IL-6 levels were increased significantly in all groups compared with the control group. These increases were significantly smaller in the BBS, NTS and BBS + NTS groups compared with the colitis group (TNF-α levels, 169. CONCLUSION:The results of this study suggest BBS and NTS, through their anti-inflammatory actions, support the maintenance of colonic integrity and merit consideration as potential agents for ameliorating colonic inflammation.

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Pectin-enriched diet affects distribution and expression of apoptosis-cascade proteins in colonic crypts of dimethylhydrazine-treated rats.

Cited by 18 publications

References 0 publications

Pectin nanoparticle enhances cytotoxicity of methotrexate against hepG2 cells

Pectin nanoparticle enhances cytotoxicity of methotrexate against hepG2 cells

Galectin-3 in apoptosis, a novel therapeutic target

Ameliorative effects of bombesin and neurotensin on trinitrobenzene sulphonic acid-induced colitis, oxidative damage and apoptosis in rats

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