Pectin/HPMC dry powder coating formulations for colon specific targeting tablets of metronidazole

Tung, Nguyen-Thach; Pham, Thi-Minh-Hue; Nguyen, Thanh-Hai; Pham, Thanh-Tam; Nguyen, Thi-Quynh

doi:10.1016/j.jddst.2016.03.004

Cited by 23 publications

(5 citation statements)

References 21 publications

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“…8 Similarly, Tung et al investigated colon-specific targeted tablets of metronidazole through a pectin/hydroxypropyl methylcellulose dry powder coating. 9 Vemula also reported double-compression-coated mini-tablets for pulsatile colonic release of flurbiprofen, 10 as well as colon-specific pH-and time-dependent tablets. 11 However, only a few studies have reported about colonspecific pulsatile nanodrug delivery systems using advanced technologies.…”

Section: Introductionmentioning

confidence: 97%

“…7 Many efforts have been dedicated to drug colon-targeted pulsatile release through traditional methods on solid dosage forms. [8][9][10][11] Vemula and Katkum reported coated tablets of ketorolac tromethamine, which were prepared using double-compression coating method. 8 Similarly, Tung et al investigated colon-specific targeted tablets of metronidazole through a pectin/hydroxypropyl methylcellulose dry powder coating.…”

Section: Introductionmentioning

confidence: 99%

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Colon-specific pulsatile drug release provided by electrospun shellac nanocoating on hydrophilic amorphous composites

Yang¹,

Liu²,

Yu³

et al. 2018

IJN

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BackgroundColon-specific pulsatile drug release, as a combined drug controlled-release model, is a useful drug delivery manner for a series of diseases. New nanomedicines and related preparation methods are highly desired.MethodsWith diclofenac sodium (DS) as a model drug, a new type of structural nanocomposite (SC), in which composite polyvinylpyrrolidone (PVP)–DS core was coated by shellac, was fabricated via modified coaxial electrospinning. For comparison, traditional PVP–DS monolithic hydrophilic nanocomposites (HCs) were generated using a traditional blending process. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), attenuated total reflectance-Fourier transform infrared (ATR-FTIR), water contact angle (WCA), and in vitro dissolution and ex vivo permeation tests were conducted to characterize the composites.ResultsSEM images demonstrated that both composites were linear nanofibers with smooth surface morphology and cross sections. TEM disclosed that the SCs had a thin shellac sheath layer of approximately 12 nm. XRD and ATR-FTIR results demonstrated that the crystalline DS was converted into amorphous composites with PVP because of favorable secondary interactions. WCA and in vitro dissolution tests demonstrated that the sheath shellac layers in SC could resist acid conditions and provide typical colon-specific pulsatile release, rather than a pulsatile release of HC under acid conditions. Ex vivo permeation results demonstrated that the SCs were able to furnish a tenfold drug permeation rate than the DS particles on the colon membrane.ConclusionA new SC with a shellac coating on hydrophilic amorphous nanocomposites could furnish a colon-specific pulsatile drug release profile. The modified coaxial process can be exploited as a useful tool to create nanocoatings.

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Colon-specific pulsatile drug release provided by electrospun shellac nanocoating on hydrophilic amorphous composites

Yang¹,

Liu²,

Yu³

et al. 2018

IJN

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“…Among the various polysaccharides used for microbially-triggered colonic release, pectin, a D-galacturonic acid-rich hetero-polysaccharide found in plant cell walls, plays a prominent role [ 27 ]. Indeed, it has broadly been used as a colon-targeting excipient, mostly combined with insoluble polymers in an attempt to mitigate the impact of the relevant hydrophilicity and water solubility characteristics and attain a durable barrier [ 28 , 29 , 30 , 31 ]. To this end, high-methoxyl pectin has been chosen.…”

Section: Introductionmentioning

confidence: 99%

Colon Drug Delivery Systems Based on Swellable and Microbially Degradable High-Methoxyl Pectin: Coating Process and In Vitro Performance

Moutaharrik,

Palugan,

Cerea

et al. 2024

Pharmaceutics

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Oral colon delivery systems based on a dual targeting strategy, harnessing time- and microbiota-dependent release mechanisms, were designed in the form of a drug-containing core, a swellable/biodegradable polysaccharide inner layer and a gastroresistant outer film. High-methoxyl pectin was employed as the functional coating polymer and was applied by spray-coating or powder-layering. Stratification of pectin powder required the use of low-viscosity hydroxypropyl methylcellulose in water solution as the binder. These coatings exhibited rough surfaces and higher thicknesses than the spray-coated ones. Using a finer powder fraction improved the process outcome, coating quality and inherent barrier properties in aqueous fluids. Pulsatile release profiles and reproducible lag phases of the pursued duration were obtained from systems manufactured by both techniques. This performance was confirmed by double-coated systems, provided with a Kollicoat® MAE outer film that yielded resistance in the acidic stage of the test. Moreover, HM pectin-based coatings manufactured by powder-layering, tested in the presence of bacteria from a Crohn’s disease patient, showed earlier release, supporting the role of microbial degradation as a triggering mechanism at the target site. The overall results highlighted viable coating options and in vitro release characteristics, sparking new interest in naturally occurring pectin as a coating agent for oral colon delivery.

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“…This problem could be overcome by choosing between pectin grades or including other polymeric excipients ( Rubinstein et al, 1993 ). Therefore, a binary polymer matrix system with pectin and hydroxypropyl methylcellulose (HPMC) was developed for drug release profile tailoring to address this hurdle ( Tung et al, 2016 ; Ugurlu et al, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

Preparation and in vitro evaluation of hot-melt extruded pectin-based pellets containing ketoprofen for colon targeting

Narala

Nyavanandi

Mandati

et al. 2023

International Journal of Pharmaceutics: X

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Pectin/HPMC dry powder coating formulations for colon specific targeting tablets of metronidazole

Cited by 23 publications

References 21 publications

Colon-specific pulsatile drug release provided by electrospun shellac nanocoating on hydrophilic amorphous composites

Colon-specific pulsatile drug release provided by electrospun shellac nanocoating on hydrophilic amorphous composites

Colon Drug Delivery Systems Based on Swellable and Microbially Degradable High-Methoxyl Pectin: Coating Process and In Vitro Performance

Preparation and in vitro evaluation of hot-melt extruded pectin-based pellets containing ketoprofen for colon targeting

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