Pectin in drug delivery applications

Rascón‐Chu, Agustín; Gomez-Rodriguez, Gabriel H.; Carvajal-Millan, Elizabeth; Campa-Mada, Alma C.

doi:10.1016/b978-0-12-817055-7.00010-8

Cited by 5 publications

(1 citation statement)

References 51 publications

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“…Polymer compounds with significant properties can be produced using natural polymer compounds. For example, recently, there have been reports on the use of pectin and other compounds, such as metal–organic frameworks and hybrid materials, in synthesizing new polymers with biomedical and drug delivery applications ( Rascón-Chu et al, 2019 ; Li et al, 2021 ; Kiadeh et al, 2021 ). Chitosan is mentioned among other natural polymers.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of a novel Cu/DPA-MOF/OP/CS hydrogel with high capability in antimicrobial studies

Jasim Al-Khafaji,

Alsalamy,

Abed Jawad

et al. 2023

Front. Chem.

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Today, with the indiscriminate use of antibiotics, we face the resistance of some bacterial strains against some antibiotics. Therefore, it is essential to report and synthesize new compounds with antimicrobial properties. A novel copper/dipicolinic acid–metal–organic framework cross-linked oxidized pectin and chitosan (Cu/DPA-MOF/OP/CS) hydrogel polymer was synthesized under environmental conditions with the controllable process, which uses biodegradable polymer compounds such as pectin and chitosan in its structure. The efficient physicochemical features of the synthesized Cu/DPA-MOF/OP/CS hydrogel using SEM, FT-IR, TGA, BET, XRD, and EDS/mapping were identified and confirmed. The newly synthesized Cu/DPA-MOF/OP/CS hydrogel showed activity against Gram-positive and Gram-negative bacterial strains and fungal species, and significant antibacterial and antifungal properties were observed. In antibacterial activity, the MIC against Gram-positive species was in the range of 16–128 mg/mL, the MIC against Gram-negative species was in the range of 64–256 mg/mL, and the MIC against fungal species was in the range of 128–512 mg/mL. In antimicrobial evaluations, in addition to the MIC test, the MBC test, the MFC test, and the IZD test were performed, and the results were reported. The results were compared with commercial antibiotics in the market. Development of novel nanostructures based on hydrogel polymers with distinctive functionality can affect the performance of these nanostructures in different areas.

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Section: Introductionmentioning

confidence: 99%

Synthesis of a novel Cu/DPA-MOF/OP/CS hydrogel with high capability in antimicrobial studies

Jasim Al-Khafaji,

Alsalamy,

Abed Jawad

et al. 2023

Front. Chem.

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Biomedical Applications of Pectin

Sharma,

Sarwan,

Chaudhary

et al. 2024

Biopolymers for Biomedical Applications

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Pectin as a biofunctional food: comprehensive overview of its therapeutic effects and antidiabetic-associated mechanisms

Soomro,

Khan,

Majid

et al. 2024

Discov Appl Sci

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Pectin is a complex polysaccharide found in a variety of fruits and vegetables. It has been shown to have potential antidiabetic activity along with other biological activities, including cholesterol-lowering properties, antioxidant activity, anti-inflammatory and immune-modulatory effects, augmented healing of diabetic foot ulcers and other health benefits. There are several pectin-associated antidiabetic mechanisms, such as the regulation of glucose metabolism, reduction of oxidative stress, increased insulin sensitivity, appetite suppression and modulation of the gut microbiome. Studies have shown that pectin supplementation has antidiabetic effects in different animal models and in vitro. In human studies, pectin has been found to have a positive effect on blood glucose control, particularly in individuals with type 2 diabetes. Pectin also shows synergistic effects by enhancing the potency and efficacy of antidiabetic drugs when taken together. In conclusion, pectin has the potential to be an effective antidiabetic agent. However, further research is needed to fully understand its detailed molecular mechanisms in various animal models, functional food formulations and safety profiles for the treatment and management of diabetes and associated complications in humans. The current study was carried out to provide the critical approach towards therapeutical potential, anti-diabetic potential and underlying molecular mechanisms on the basis of existing knowledge.

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Pectin in drug delivery applications

Cited by 5 publications

References 51 publications

Synthesis of a novel Cu/DPA-MOF/OP/CS hydrogel with high capability in antimicrobial studies

Synthesis of a novel Cu/DPA-MOF/OP/CS hydrogel with high capability in antimicrobial studies

Biomedical Applications of Pectin

Pectin as a biofunctional food: comprehensive overview of its therapeutic effects and antidiabetic-associated mechanisms

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