Urgency of the research. Government regulation of the economy is essential for sustainable development of the national economy as it’s the cause of developing a structural policy strategy. Target setting. The main goals of government structural policy are the rapid transition from the crisis to economic growth and increasing global competitiveness. Actual scientific researches and issues analysis. Structural and economic development issues have been addressed in their research by such scholars as Vdovenko N., Nakonechna K., Heiets V., Shynkaruk L., Artomova T., Lebedieva O., Popadynets N., Shtefan S., Thoben K., Wiesner S., Wuest T., Liao Y., Deschamps F., Loures E., Ramos L., Higginbotham B., Barbaroux P., Sassen S., Lineberger R., Crawford I. Uninvestigated parts of general matters defining. The theories of structural policy necessitate their study to develop effective policy measures in strategic sectors of the national economy. The research objective. The purpose of the article is to substantiate ways of ensuring qualitative changes in the mechanism of government regulation of the development of strategic branches of the national economy. The statement of basic materials. The main directions of the structural policy are considered in the article. The main models of active and passive structural policy are identified. The basic principles of formation of industrial development strategy and structural changes of strategic branches of economy are established. The basic framework of the implementation of the structural policy in space industry is outlined. Conclusions. It has been found that many countries of the world created new industrial development strategies. It is determined that the goals of the new direction of government regulation of strategic industries are not only to accelerate and promote the economic development of these industries, but also to create jobs, fight poverty, participate in the technological revolution and global value chains.