Peculiarities of active avoidance conditioning in rats with various forms of inherited arterial hypertension

Abstract

Peculiarities of active avoidance conditioning were studied in NISAG rats (hereditary stress-induced arterial hypertension) and spontaneously hypertensive SHR rats. Conditioning was successful in 90% normotensive Wistar rats and in only 9.1% NISAG rats. Hypertensive SHR rats were intermediate between Wistar and NISAG rats by their learning capacity (66.7%). Our results suggest that differences in learning capacity of hypertensive rats are determined by genetic characteristics of animal behavior and emotional state, rather than blood pressure elevation.

Comparison of SHR, WKY and Wistar rats in different behavioural animal models: effect of dopamine D1 and alpha2 agonists

“…Up to now, there are no further reports about the behaviour of SHR and WKY rats in the novel object recognition task regarding long-term memory. Data on memory from active and passive avoidance are contradictory (Loskutova et al 2006). For ADHD patients, no impairment of long-term memory is reported (Kaplan et al 1998;Kibby and Cohen 2008).…”

Peculiarities of Latent Inhibition Formation in SHR Rats in Conditioned Task of Different Complexity

“…In numerous studies SHR rats are used as a genetic model of attention defi cit hyperactivity syndrome for elucidation of its neurobiological and other mechanisms. Disturbances in conditioned activity in these animals are unequivocal in any behavioral tasks from simple recognition (social memory) to complex discrimination in mazes [1,2,4,8,9]. Apart from poor learning, prolonged retention of memory trace was observed in repeated conditioned passive avoidance testing in SHR rats [1], which could be stipulated by inadequate maintenance of attention to non-reinforced conditioned stimulus.…”