Pediatric allergic conjunctivitis and allergic rhinitis

Qiao, Tong; Hu, Yuelin; Wang, Zhinan

doi:10.1016/s1007-4376(08)60061-1

Cited by 6 publications

(7 citation statements)

References 18 publications

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“…9 b) protein expression in V. volvacea was up-regulated during exposure to cold stress. This result further proves that cor1 is involved in the response of V. volvacea to low-temperature stress at both the gene 11 and protein levels and provides a theoretical reference for future improvements in V. volvacea .…”

Section: Discussionsupporting

confidence: 65%

“…It has speculated that the expression of the cor1 gene in V. volvacea after low-temperature treatment might be related to the low-temperature tolerance. In addition, it has been reported that the cor1 gene might be involved in the response to low-temperature stress 11 , 40 , such as by blocking changes in membrane lipids and increasing the levels of sugars and soluble proteins, which effectively prolongs the survival time of the mycelia of V. volvacea at 4 °C 40 . Newly synthesized proteins might enter or be adsorbed through the surface membrane, alter the stability of the membrane, or be distributed into the intercellular space, which would prevent or accelerate the cooling process 41 .…”

Section: Discussionmentioning

confidence: 99%

“…The fungus is usually autolysed at 0–5 °C 9 , 10 , and this autolysis accelerates its decay and causes softening and liquefaction. Therefore, the postharvest storage problem of V. volvacea has become a bottleneck that restricts its commercial development 11 . In our previous study, changes in the color, weight loss rate, relative conductivity and malondialdehyde (MDA) content of V. volvacea , which are key indicators of its quality, were measured during the storage at 4 °C.…”

Section: Introductionmentioning

confidence: 99%

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Differential proteomics study of postharvest Volvariella volvacea during storage at 4 °C

Chen

et al. 2020

Sci Rep

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The postharvest storage of Volvariella volvacea is an important factor limiting the industry development. Low-temperature storage is the traditional storage method used for most edible fungi, but V. volvacea undergoes autolysis at low temperature. To understand the molecular mechanism underlying the low-temperature autolysis of V. volvacea after harvesting, fruiting bodies of V. volvacea strain V23 were stored at 4 °C. Based on our previous study, in which the changes of morphological and physiological indexes during storage for 0, 6, 12, 24, 30, 36, 48 and 60 h were measured; four time points, namely, 0, 12, 24 and 60 h, were selected for this differential proteomics study. The proteomic changes in the postharvest storage samples were studied by isobaric tags for relative and absolute quantification-coupled two-dimensional liquid chromatography-tandem mass spectrometry (2D LC-MS/MS). A total of 2,063 proteins were identified, and 192 differentially expressed proteins (DEPs), including 24 up-regulated proteins and 168 down-regulated proteins, were detected after 12 h of storage. After 24 h of storage, 234 DEPs, including 48 up-regulated and 186 down-regulated proteins, were observed, and after 60 h, 415 DEPs, including 65 up-regulated proteins and 350 down-regulated proteins, were observed. An in-depth data analysis showed that the DEPs participated in various cellular processes, particularly metabolic processes. In this study, we combined Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses, and the results focused on oxidative phosphorylation and ubiquitin mediated proteolysis pathways. In addition, sdh2, uba1 and ubc1 was confirmed by quantitative real-time polymerase chain reaction, and the results showed that the expression of these genes were consistent with their protein level. Based on the literature and our results, it is speculated that the identified DEPs, such as ATP1, SDH2, COR1, UBA1, COX4, UBC1 and SKP1 play a key role in the low-temperature autolysis of V. volvacea. Volvariella volvacea is a commercially important edible fungus cultivated in tropical and subtropical regions, particularly in Southeast Asian countries 1,2. In recent years, the market demand for V. volvacea has rapidly increased due to its unique flavor 3 and high nutritional value 4. V. volvacea also has pharmaceutical value because it contains antitumor polysaccharides and immunomodulatory lectins 5-7. V. volvacea is delicious and mainly sold fresh. In addition, this fungus exhibits rapid growth and development, has high respiratory intensity, and is easy-to-open umbrella at 28-35 °C, and these features are responsible for the loss of its edible value over a short period of time 8. In addition, V. volvacea is native to tropical and subtropical regions and is thus sensitive to low temperature. The fungus is usually autolysed at 0-5 °C 9,10 , and this autolysis accelerates its decay and causes softening and liquefaction. Therefore, the postharvest storage problem of V. volvacea has become a bottleneck that restr...

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Differential proteomics study of postharvest Volvariella volvacea during storage at 4 °C

Chen

et al. 2020

Sci Rep

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“…The exact prevalence of allergic conjunctivitis in children with AR cannot be determined as the patients usually do not self report eye symptoms and do not attach much importance to it [ 1 ]. A study from China revealed that 430/485 (89%) children with AR had concomitant allergic conjunctivitis [ 33 ]. Allergen exposure of nasal or conjunctival mucosa may lead to inflammation at both the places probably due to anatomical contiguity.…”

Section: Introductionmentioning

confidence: 99%

Impact of allergic rhinitis in school going children

Mir

Panjabi

Shah

2012

Asia Pacific Allergy

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Allergic rhinitis (AR) is the most common chronic pediatric disorder. The International Study for Asthma and Allergies in Childhood phase III found that the global average of current rhinoconjunctivitis symptoms in the 13-14 year age-group was 14.6% and the average prevalence of rhinoconjunctivitis symptoms in the 6-7 year age-group was 8.5%. In addition to classical symptoms, AR is associated with a multidimensional impact on the health related quality of life in children. AR affects the quality of sleep in children and frequently leads to day-time fatigue as well as sleepiness. It is also thought to be a risk factor for sleep disordered breathing. AR results in increased school absenteeism and distraction during class hours. These children are often embarrassed in school and have decreased social interaction which significantly hampers the process of learning and school performance. All these aspects upset the family too. Multiple co-morbidities like sinusitis, asthma, conjunctivitis, eczema, eustachian tube dysfunction and otitis media are generally associated with AR. These mostly remain undiagnosed and untreated adding to the morbidity. To compound the problems, medications have bothersome side effects which cause the children to resist therapy. Children customarily do not complain while parents and health care professionals, more often than not, fail to accord the attention that this not so trivial disease deserves. AR, especially in developing countries, continues to remain a neglected disorder.

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“…Under certain conditions, the caps of the mushrooms can easily open after harvest, reducing their edible value ( Zhu et al, 2010 ). At the same time, because V. volvacea is a kind of high-temperature edible fungus that is sensitive to temperature change, it is usually hydrated and autolyzed at 0°C∼5°C ( Chen et al, 1995 ; Yang et al, 2002 ), which accelerates its decay, making it soft and liquefied and leading to low-temperature autolysis ( Qiao, 2008 ). Therefore, the development of the V. volvacea industry has been greatly limited.…”

Section: Introductionmentioning

confidence: 99%

The Response of Volvariella volvacea to Low-Temperature Stress Based on Metabonomics

Zhao

Chen

et al. 2020

Front. Microbiol.

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Low temperature can lead to the autolysis of Volvariella volvacea ( V. volvacea ), hindering its growth and preservation and severely reducing its yield and quality. This autolysis of V. volvacea at low temperature has been reported, but a metabolomics-based investigation of the underlying mechanisms of the V. volvacea response to low temperature has not been reported. Therefore, this study aimed to explore the changes, levels and expression patterns of V. volvacea metabolites at low temperature. To understand the metabolic differences within V. volvacea , two strains with different levels of low-temperature tolerance were treated in an ice bath at 0°C for 2, 4, 8, and 10 h, while the blank control group was treated for 0 h. Metabonomics analysis was adopted to study the changes in V. volvacea in response to low temperature and the differences between the two different strains. Metabolic curves were analyzed at different time points by high-performance liquid chromatography-mass spectrometry (HPLC-MS). A total of 216 differential metabolites were identified and enriched in 39 metabolic pathways, mainly involving amino acid metabolism, carbohydrate metabolism, the TCA cycle, energy metabolism, etc. In this paper, we report the metabonomic analysis of V. volvacea in response to low temperature and compare the differences in metabolite expression between the low-temperature-resistant strain VH3 and the low-temperature-sensitive strain V23. Finally, the putative low-temperature resistance mechanism of VH3 is revealed at the metabolic level. This study provides a theoretical basis for revealing the regulatory mechanism of low-temperature resistance in V. volvacea and for future molecular breeding efforts.

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Pediatric allergic conjunctivitis and allergic rhinitis

Cited by 6 publications

References 18 publications

Differential proteomics study of postharvest Volvariella volvacea during storage at 4 °C

Differential proteomics study of postharvest Volvariella volvacea during storage at 4 °C

Impact of allergic rhinitis in school going children

The Response of Volvariella volvacea to Low-Temperature Stress Based on Metabonomics

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