Pediatric Asthma: A Global Epidemic

Serebrisky, Denise; Wiznia, Andrew

doi:10.5334/aogh.2416

Cited by 199 publications

(149 citation statements)

References 43 publications

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“…In contrast, results from other studies did not support the effect of asthma on adiposity accumulation [13] or overweight/obesity development [14]. Additionally, it is worth noting that the vast majority of existing evidence was based on data from the US [7,8,10,11] or European countries [5,6,12], where the prevalence of asthma and obesity are relatively high [15,16], conferring an uncertainty when applied to other populations. To our knowledge, only one prior study has examined the effect of asthma on adiposity among 5138 Chinese-ancestry children aged 9-13 years [13].…”

Section: Introductionmentioning

confidence: 95%

Association between Physician-Diagnosed Asthma and Weight Status among Chinese Children: The Roles of Lifestyle Factors

Lai

Zhang

Zeng

et al. 2020

IJERPH

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Childhood asthma and obesity have posed a parallel epidemic over the past few decades. However, whether asthma diagnosis is associated with obesity, and what the roles of lifestyle factors play in this relationship, remained unclarified. This study aimed to investigate the association between asthma and weight status in Chinese children and explore the potential mediating and/or modifying roles of lifestyle factors in the association. In this cross-sectional study, 16,837 children aged 6–12 years were recruited from Guangzhou, China. Participants’ information on physician-diagnosed asthma was collected from parents, and data on physical activity, screen time, and sleeping were reported in a validated questionnaire. Height and weight were objectively measured, and weight status was classified by body mass index (BMI). Multiple logistic regression analysis and mediation analysis were used. Results showed that asthmatic children were at significantly higher risk of obesity (odds ratio (OR) 1.51, 95% confidence interval (CI) 1.03, 2.21) compared with non-asthmatic children. More importantly, this increased risk was even greater in children with moderate-to-vigorous physical activity <60 min/d and children with screen time >2 h/d (both Pinteraction < 0.05). Also, a positive relationship of asthma with overweight was found in children with screen time >2 h/d (OR 3.92, 95% CI 1.56, 9.88), while a negative association was observed between asthma and underweight in children aged 9–12 years (OR 0.23, 95% CI 0.06, 0.92). Mediation analysis indicated that these associations were not mediated by physical activity, screen time, or sleeping. The findings suggested that physician-diagnosed asthma was associated with higher risks of overweight and obesity, and these risks might be exacerbated by insufficient physical activity and prolonged screen time.

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Section: Introductionmentioning

confidence: 95%

Association between Physician-Diagnosed Asthma and Weight Status among Chinese Children: The Roles of Lifestyle Factors

Lai

Zhang

Zeng

et al. 2020

IJERPH

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“…Childhood asthma is the most common chronic respiratory disease, and it has reached epidemic proportions worldwide (1). Global statistics show that death rates from asthma in children range from 0 to 0.7 per 100,000 people (1).…”

Section: Introductionmentioning

confidence: 99%

Pre-pregnancy Maternal Weight and Gestational Weight Gain Increase the Risk for Childhood Asthma and Wheeze: An Updated Meta-Analysis

et al. 2020

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Background: Mounting evidence suggests that childhood asthma is closely associated with maternal weight before pregnancy and gestational weight gain (GWG), yet the results are not often reproducible. Objectives: We conducted a comprehensive meta-analysis, aiming to evaluate the association of pre-pregnancy maternal obesity or overweight and high GWG with the risk for childhood asthma and wheeze. Methods: Literature search, quality assessment, and data extraction were completed independently and in duplicate. Effect-size estimates are expressed as odds ratio (OR) with 95% confidence interval (CI). Results: Twenty-two observational studies involving 145,574 mother-child pairs were meta-analyzed. In overall analyses, maternal obesity or overweight in pre-pregnancy significantly increased the risk of both childhood asthma and wheeze (adjusted OR: 1.41 and 1.13, 95% CI: 1.26-1.59 and 1.07-1.20, both p < 0.001). Per 1 kg/m 2 increment in maternal body mass index was associated with a significantly increased risk of childhood asthma and wheeze (adjusted OR: 1.03, 95% CI: 1.02-1.03, p < 0.001). Compared with normal GWG, very high GWG (adjusted OR: 1.24, 95% CI: 1.04-1.47, p: 0.018), moderate high GWG (adjusted OR: 1.12, 95% CI: 1.04-1.21, p: 0.004), and very low GWG (adjusted OR: 1.26, 95% CI: 1.08-1.47, p: 0.004) increased the risk of childhood asthma and wheeze. There was a low probability of publication bias. Conclusions: Our findings indicate that both pre-pregnancy maternal obesity or overweight and very to moderate high or low GWG render their offspring susceptible to a significantly increased risk of having childhood asthma and wheeze.

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“…Asthma is the most common chronic disease in children . Asthma often begins in childhood, and it remains a worldwide serious public health problem reaching epidemic proportions . Global death rates from childhood asthma range from 0 to 0.7 per 100 000 persons .…”

Section: Introductionmentioning

confidence: 99%

“…Asthma often begins in childhood, and it remains a worldwide serious public health problem reaching epidemic proportions . Global death rates from childhood asthma range from 0 to 0.7 per 100 000 persons . According to the Global Asthma Report 2018, an estimated 340 million persons are experiencing asthma, and nearly 1000 persons die of asthma‐related conditions per day, and most of all these deaths are preventable, highlighting the importance of early prevention measures in promoting pulmonary health, especially among children.…”

Section: Introductionmentioning

confidence: 99%

Association between overweight or obesity and the risk for childhood asthma and wheeze: An updated meta‐analysis on 18 articles and 73 252 children

Deng

Yuan

et al. 2019

Pediatric Obesity

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Background: Overweight or obesity is increasingly recognized as a possible risk factor for childhood asthma. Objectives:We aimed to meta-analyse the association between overweight or obesity and the risk for childhood asthma and wheeze and meanwhile explore potential causes of between-study heterogeneity.Methods: Literature search, study selection, and data extraction were performed independently and in duplicate. Data were analysed by STATA software.Results: Eighteen articles and 73 252 children were analysed. In overall analyses, there was a significant association between overweight or obesity and the risk for childhood asthma (odds ratio [OR] = 1.30; 95% confidence interval [CI], 1.23-1.39; P < 0.001) and wheeze (OR = 1.90; 95% CI, 1.38-2.63; P < 0.001), with none/marginal publication bias as revealed by the Egger test (P = 0.938/0.038), respectively. Subgroup analyses showed that children with obesity (OR = 1.40; 95% CI, 1.29-1.52) were more likely to have asthma than children with overweight (OR = 1.22; 95% CI, 1.14-1.31), and in children with overweight or obesity, girls (OR = 1.34; 95% CI, 1.16-1.56) were more likely to have asthma than boys (OR = 1.27; 95% CI, 1.15-1.40). Conclusions:Our findings indicate that overweight or obesity is a significant risk factor for childhood asthma and wheeze and in children with overweight or obesity, the risk is more evident in girls than in boys.

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Pediatric Asthma: A Global Epidemic

Cited by 199 publications

References 43 publications

Association between Physician-Diagnosed Asthma and Weight Status among Chinese Children: The Roles of Lifestyle Factors

Association between Physician-Diagnosed Asthma and Weight Status among Chinese Children: The Roles of Lifestyle Factors

Pre-pregnancy Maternal Weight and Gestational Weight Gain Increase the Risk for Childhood Asthma and Wheeze: An Updated Meta-Analysis

Association between overweight or obesity and the risk for childhood asthma and wheeze: An updated meta‐analysis on 18 articles and 73 252 children

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