Pediatric Ovarian Malignancies

Breen, James; Denehy, Thad R.; Taylor, Robert

doi:10.3843/glowm.10251

Cited by 6 publications

(8 citation statements)

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“…Grossly, dysgerminomas are rubbery, gray, smooth, or bosselated and are surrounded by a dense capsule. The cut surface is soft and homogeneous and has a brainlike consistency, 11,12 that is similar to what was found in the index case. Elevated LDH can be an early clinical sign of an ovarian dysgerminoma.…”

Section: Discussionsupporting

confidence: 74%

A huge abdomino-pelvis tumour in a prepubertal girl: A case report of dysgerminoma infiltrating both ovaries and uterus in an 11-year-old girl in Maiduguri

Farouk¹,

Farate²,

Wabada³

et al. 2021

Ann Afr Med Res

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Dysgerminoma is one of the rare highly malignant ovarian germ cell tumour. It originate from undifferentiated germ cells that are similar to primordial germ cells, and it is identical to testicular seminoma in males. Despite the tumour being malignant, prognosis is excellent with surgery and adjuvant chemotherapy, with promising results concerning future fertility. In this case, we report an 11-year-old girl with abdominal swelling for 7 years. She had gross abdominal distension, with a huge palpable mass. Abdominopelvic ultrasound scan showed a huge heterogeneous mass measured 9.8 cm x 15.7 cm and computed tomography showed a huge lobulated mass measured 19.2 cm x 19.0 cm x 16.3 cm. Exploratory laparotomy and excision of the mass was done. Ovarian dysgerminoma are uncommon in prepubertal girls. Prognosis depends on the stage at presentation and histology. Multidisciplinary management with a Gynaecologists and Oncologists with joint decision on the need to maintain the child’s developmental and reproductive potential as much as possible should aimed at.

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Section: Discussionsupporting

confidence: 74%

A huge abdomino-pelvis tumour in a prepubertal girl: A case report of dysgerminoma infiltrating both ovaries and uterus in an 11-year-old girl in Maiduguri

Farouk¹,

Farate²,

Wabada³

et al. 2021

Ann Afr Med Res

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“…Пик заболеваемости приходится на женщин молодого возраста и подростков (15-20 лет). в структуре злокачественных новообразований яичника у детей зГОЯ составляют до 70 % [8,11].…”

Section: эпидемиологияunclassified

Ovarian germ cell tumors - a modern approach to the problem

et al. 2016

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“…Neoplastic ovarian tumors in children and adolescents are rare, and the reported incidence in this age group ranges from 0.9 to 2% of all tumor types [ 7 ]. Several studies have also reported an incidence of approximately 2.6 cases per 100,000 females per year in this age group [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…The malignant tumors mostly are treatable, and have high survival rates. However, these indolent malignant tumors tend to become aggressive when inadequately treated [ 8 ]. Thus, the main goal of management is to promote an excellent outcome while reducing morbidity and preserving fertility.…”

Section: Introductionmentioning

confidence: 99%

Ovarian neoplasia in adolescence: a retrospective chart review of girls with neoplastic ovarian tumors in Saudi Arabia

Aldakhil

Aljuhaimi

AlKhattabi³

et al. 2022

J Ovarian Res

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Background Ovarian neoplasia in children and adolescents is a rare tumor. The diagnosis and management of such tumors is often difficult and delayed due to non-specific symptoms and low suspicion. Surgical management that preserves fertility and ovarian function should be the goal. Objective This study aimed to review the clinical presentation, tumor characteristics, and management of Saudi Arabian adolescents. Methods A retrospective chart review was conducted on adolescent girls aged 19 or less admitted to tow referral hospital in Riyadh, Saudi Arabia, diagnosed with adnexal mass over an 8 years’ period; patients who were older than 19 were excluded. The data collected from patients’ charts included age, presenting symptoms, radiologic findings, type of surgery, specialist who performed the surgery, and histopathology of the tumors. We classified patients according to age using the three WHO developmental stages: early adolescence (10–13 years old), middle adolescence (14–16 years old), and late adolescence (16–17 years old). The statistical study used SPSS version 18.0 to determine the data’s frequency, distributions, and means (SPSS Inc., Chicago, IL). Results We analyzed 164 patients, between 10 and 19 years old, admitted to two hospitals between 2009 and 2017. We found that 85% of these patients underwent surgery for adnexal mass removal, and 90.2% were symptomatic or emergency cases. The majority of our patients were post-menarche (96.95%), and were between the ages of 14 and 19. The most common surgical procedure for tumor removal was laparoscopic cystectomy (74.4%). An adnexal mass with a solid component on ultrasound is the most commonly found indicator of malignancy. The majority of tumors were benign (32.3%). Germ cell tumors were the most common (68.7%) malignant tumor, and yolk sac tumors were the most common subgroup of germ cell tumors. When managed by a gynecologist, surgical intervention can be a successful method of preserving fertility. Conclusions Our results confirm that the majority of neoplastic ovarian tumors in children and adolescents are benign, and surgical intervention can be used to maintain fertility, especially when managed by a gynecologist. This is one of the largest reported series and the first from our area.

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Pediatric Ovarian Malignancies

Cited by 6 publications

References 0 publications

A huge abdomino-pelvis tumour in a prepubertal girl: A case report of dysgerminoma infiltrating both ovaries and uterus in an 11-year-old girl in Maiduguri

A huge abdomino-pelvis tumour in a prepubertal girl: A case report of dysgerminoma infiltrating both ovaries and uterus in an 11-year-old girl in Maiduguri

Ovarian germ cell tumors - a modern approach to the problem

Ovarian neoplasia in adolescence: a retrospective chart review of girls with neoplastic ovarian tumors in Saudi Arabia

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