Pediatric perspective on prenatal counseling for myelomeningocele

Doherty, Daniel; Shurtleff, David B.

doi:10.1002/bdra.20297

Cited by 9 publications

(2 citation statements)

References 109 publications

(85 reference statements)

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“…The severity of spina bifida is more variable. Complications of spina bifida can lead to death; however, this is not the most common outcome, with over 90% of liveborn infants with spina bifida in the United States surviving the first year of life with varying levels of sensory loss and paralysis (Bol et al, 2006;Doherty and Shurtleff, 2006).…”

Section: Introductionmentioning

confidence: 99%

Pregnancy termination following prenatal diagnosis of anencephaly or spina bifida: A systematic review of the literature

Johnson¹,

Honein²,

Flanders³

et al. 2012

Birth Defects Research

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Background-In regions where prenatal screening for anencephaly and spina bifida is widespread, many cases of these defects are prenatally diagnosed. The purpose of this study was to estimate the frequency of termination of pregnancy (TOP) following prenatal diagnosis of anencephaly or spina bifida and to investigate factors associated with TOP that might lead to selection bias in epidemiologic studies.

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Section: Introductionmentioning

confidence: 99%

Pregnancy termination following prenatal diagnosis of anencephaly or spina bifida: A systematic review of the literature

Johnson¹,

Honein²,

Flanders³

et al. 2012

Birth Defects Research

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“…12, 35 The precise worldwide incidence of MMC has been difficult to assess given the variations in prenatal diagnosis and in policies regarding the elective termination of pregnancy. 8,21 In more technologically advanced countries, despite folic acid supplementation and routine prenatal screening, administered as early as the first trimester, MMC still affects nearly 1 in 2000 live births. 1 Newborns with MMC present with various degrees of lower-extremity paralysis, sexual and sphincter dysfunction, tethering of the spinal cord, skeletal deformation, brainstem dysfunction, hydrocephalus, and ventriculoperitoneal shunt complications.…”

mentioning

confidence: 99%

Vascular and apoptotic changes in the placode of myelomeningocele mice during the final stages of in utero development

Reis

Correia‐Pinto

Monteiro

et al. 2008

PED

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Object Myelomeningocele (MMC) is a primary neurulation defect that is associated with devastating neurological disabilities in affected newborns. To better characterize the in utero neurodegenerative process of MMC, the authors investigated the changes in vascular organization, apoptosis, and the presence of inflammatory cells during gestation by using a mutant mouse model of MMC. Methods The curly tail/loop tail (ct/lp) mutant mouse model of MMC was chosen to obtain fetuses at different stages of gestation. Mouse fetuses harboring MMC were harvested by caesarean section at embryonic Days 14.5, 16.5, and 18.5 (complete mouse gestation at 19 days, 6 mice/group); littermate fetuses with the same gestational age but without an MMC were used as controls. Samples of the MMC placode or normal spinal cord were stained for immunocytochemical labeling with caveolin antibody (endothelium marker) and activated caspase-3 antibody (apoptosis marker). Samples were morphometrically analyzed with a computer-assisted image analyzer. Results The MMC mice presented with an increase in vascular density from embryonic Days 16.5–18.5 and an enhanced number of apoptotic cells at embryonic Day 18.5, compared with controls. There were scarce signals of an inflammatory reaction in the MMC placode, as a few infiltrating neutrophils were seen only at embryonic Day 18.5. Conclusions Fetal placodes in MMC mice showed evidence of increased vascular density since embryonic Day 16.5 and increased apoptosis at embryonic Day 18.5. These new data support the view that in utero changes of the MMC placode, occurring during the last stages of gestation, contribute to the neuropathological manifestations in full-term newborns with MMC.

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Amniotic Fluid Constituents, Cell Culture, and Neural Tube Defects

Dyke

Milunsky

2015

Genetic Disorders and the Fetus

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Pediatric perspective on prenatal counseling for myelomeningocele

Abstract: This review provides a broad overview of many of the issues encountered during prenatal counseling sessions and emphasizes the additional value of the pediatric perspective during the process of informed decision making or preparation for an the birth of an affected child.

Cited by 9 publications

References 109 publications

Pregnancy termination following prenatal diagnosis of anencephaly or spina bifida: A systematic review of the literature

Pregnancy termination following prenatal diagnosis of anencephaly or spina bifida: A systematic review of the literature

Vascular and apoptotic changes in the placode of myelomeningocele mice during the final stages of in utero development

Amniotic Fluid Constituents, Cell Culture, and Neural Tube Defects

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