Pediatric pulse dose corticosteroid therapy dosing and administration in the treatment of alopecia areata: A review of literature

Gallaga, Natalya M; Carrillo, Brenda; Good, Allison; Munoz-Gonzalez, Ayezel; Ross, Lindy

doi:10.1111/pde.15209

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…Furthermore, corticosteroids are used as a treatment in AA [ 93 , 94 , 95 ]. Topical corticosteroids and pulse dose corticosteroid therapy also show effectiveness in pediatric AA [ 96 , 97 ].…”

Section: Acth Crh and Cortisolmentioning

confidence: 99%

The Hormonal Background of Hair Loss in Non-Scarring Alopecias

Owecka,

Tomaszewska,

Dobrzeniecki

et al. 2024

Biomedicines

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Hair loss is a common clinical condition connected with serious psychological distress and reduced quality of life. Hormones play an essential role in the regulation of the hair growth cycle. This review focuses on the hormonal background of hair loss, including pathophysiology, underlying endocrine disorders, and possible treatment options for alopecia. In particular, the role of androgens, including dihydrotestosterone (DHT), testosterone (T), androstenedione (A4), dehydroepiandrosterone (DHEA), and its sulfate (DHEAS), has been studied in the context of androgenetic alopecia. Androgen excess may cause miniaturization of hair follicles (HFs) in the scalp. Moreover, hair loss may occur in the case of estrogen deficiency, appearing naturally during menopause. Also, thyroid hormones and thyroid dysfunctions are linked with the most common types of alopecia, including telogen effluvium (TE), alopecia areata (AA), and androgenetic alopecia. Particular emphasis is placed on the role of the hypothalamic–pituitary–adrenal axis hormones (corticotropin-releasing hormone, adrenocorticotropic hormone (ACTH), cortisol) in stress-induced alopecia. This article also briefly discusses hormonal therapies, including 5-alpha-reductase inhibitors (finasteride, dutasteride), spironolactone, bicalutamide, estrogens, and others.

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Section: Acth Crh and Cortisolmentioning

confidence: 99%

The Hormonal Background of Hair Loss in Non-Scarring Alopecias

Owecka,

Tomaszewska,

Dobrzeniecki

et al. 2024

Biomedicines

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“…Systemic corticosteroids are reserved for more extensive or rapidly progressing AA due to their potential side effects and are used cautiously in pediatric cases. A recent analysis encompassing eight studies and involving 216 children found that 56% experienced more than 50% hair regrowth on their scalp after undergoing treatment with pulse systemic steroids [6]. Several investigations have focused on pediatric patients undergoing methotrexate therapy.…”

Section: Andandmentioning

confidence: 99%

Noninfectious causes of alopecia in the pediatric population

Saliba,

Shah,

Wahood

et al. 2024

Current Opinion in Pediatrics

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Purpose of review To highlight recent advances in the knowledge base surrounding noninfectious causes of alopecia in the pediatric population. Recent findings Recent developments in the literature included assessments of treatment efficacy, diagnostic utility of trichoscopy, and retrospective studies characterizing the clinical picture of pediatric cases. Summary These findings will equip practitioners with the recent advances in the field's understanding of noninfectious causes of alopecia in the pediatric population.

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“…In a subsequent pediatric review of 8 studies (216 children), 56% reported >50% regrowth of scalp hair. 64 …”

Section: Corticosteroidsmentioning

confidence: 99%