Pediatric thyroid nodules: A single center experience

Trahan, Jason; Reddy, Abhita; Chang, Ellen T.; Gómez, Ricardo; Prasad, Pinki; Jeyakumar, Anita

doi:10.1016/j.ijporl.2016.06.011

Cited by 15 publications

(11 citation statements)

References 15 publications

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“…However, the specific association with the pediatric population described by Prasad et al was refuted by the fact that Giorgadze et al included only 1 adolescent patient among 13 cases. The same contrasting results were confirmed by Trahan et al in their series . Giorgadze et al sought to define and examine all the different morphological features and patterns by describing all the cytoplasm and nuclear details that might be useful in achieving this diagnosis on cytology.…”

Section: Malignancies and Pediatric Seriesmentioning

confidence: 77%

“…Specifically, they found 6 false‐positive indeterminate lesions, but they did not report any false‐negative cases. However, the low specificity of ICC is offset by the high specificity and positive predictive value of molecular alterations in thyroid neoplasms, which have been suggested as strong indicators of cancer . In fact, these last decades have been characterized by the identification of several oncogenic mutations, which are considered to be key milestones in the Thyroid Cancer Genome Atlas .…”

Section: Ancillary Techniques and Pediatric Malignanciesmentioning

confidence: 99%

“…The same contrasting results were confirmed by Trahan et al in their series. [41][42][43]55 Giorgadze et al sought to define and examine all the different morphological features and patterns by describing all the cytoplasm and nuclear details that might be useful in achieving this diagnosis on cytology. In fact, 11 of 13 cases were recognized as belonging to Bethesda categories V and VI (suspicious for malignancy [SM] and malignant, respectively), and for 1 of these cases, the authors suggested a solid variant of PTC.…”

Section: Malignancies and Pediatric Seriesmentioning

confidence: 99%

“…However, the low specificity of ICC is offset by the high specificity and positive predictive value of molecular alterations in thyroid neoplasms, which have been suggested as strong indicators of cancer. 34,[39][40][41][42][43][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69] In fact, these last decades have been characterized by the identification of several oncogenic mutations, which are considered to be key milestones in the Thyroid Cancer Genome Atlas. 68 Specifically, the atlas discriminated PTCs as either BRAF V600E -or RAS-driven tumors.…”

Section: Ancillary Techniques and Pediatric Malignanciesmentioning

confidence: 99%

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The role of thyroid FNA cytology in pediatric malignant lesions: An overview of the literature

Rossi

Martini

Cenci

et al. 2017

Cancer Cytopathology

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When one is dealing with pediatric thyroid lesions, fine-needle aspiration is the first diagnostic tool for the correct characterization of these nodules. Despite the apparent infrequency of thyroid cancers in children, recent data from the National Cancer Institute prove that the incidence has been increasing, especially in adolescents. With the same data, a higher prevalence of well-differentiated cancers can be estimated, with 90% diagnosed as papillary thyroid cancer. Nonetheless, some publications have demonstrated that some specific malignant variants are more frequent in children and have a more aggressive behavior that justifies the increased number of surgical procedures. For this reason, the American Thyroid Association recommends the performance of neck ultrasonography and fine-needle aspiration cytology (FNAC) for the evaluation of pediatric thyroid nodules. Accordingly, as reported in adult thyroid series, several authors have documented the high sensitivity and diagnostic accuracy of FNAC in pediatric series; they have also shared the same problematic issues encountered in adult populations, mostly in the diagnosis of indeterminate lesions. To provide precise clinical and/or surgical management, the correct cytological identification of specific malignant histotypes/entities should be mandatory because lymph nodes, distant metastases, and extrathyroidal infiltration are more frequent within specific histotypes. A perusal of the literature shows that their identification has not been extensively studied and investigated in cytological samples. This review focuses on the analysis of data from the literature on the evaluation of malignancies and specific morphological features in pediatric thyroid lesions. Cancer Cytopathol 2017;125:594-603. © 2017 American Cancer Society.

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Section: Malignancies and Pediatric Seriesmentioning

confidence: 77%

Section: Ancillary Techniques and Pediatric Malignanciesmentioning

confidence: 99%

Section: Malignancies and Pediatric Seriesmentioning

confidence: 99%

Section: Ancillary Techniques and Pediatric Malignanciesmentioning

confidence: 99%

See 2 more Smart Citations

The role of thyroid FNA cytology in pediatric malignant lesions: An overview of the literature

Rossi

Martini

Cenci

et al. 2017

Cancer Cytopathology

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“…The reported malignancy rate is variable, and in the results of a 10-year retrospective study of 120 pediatric thyroid nodules, investigators found that 19 patients (16%) had malignant nodules (2). In the results of another single-center 21-year study of 125 pediatric patients undergoing fine-needle aspiration biopsy (FNAB) or thyroidectomy, 16 patients (12.8%) had thyroid cancer, 14 of whom had papillary cancer and two medullary cancer (14).…”

Section: Epidemiologymentioning

confidence: 99%

Sonographic Evaluation of Pediatric Thyroid Nodules

et al. 2017

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A thyroid nodule detected clinically or incidentally at medical imaging is a common indication for ultrasonography (US) in the adult population. This scenario is less frequently the case in pediatric patients, and the approach to evaluation of thyroid nodules deserves modification in these patients because of the increased probability of malignancy in children, compared with adults. Evaluating a thyroid nodule with US in a systematic way requires familiarity with a number of features that can be assessed and the terms that the radiologist uses in each category. The probability of malignancy is influenced by certain features, and several models have emerged to integrate these details into an overall risk assessment to guide management and biopsy of thyroid nodules. Clinical features of thyroid cancer differ between pediatric and adult patients, and risk factors and certain genetic syndromes portend earlier manifestation of thyroid malignancy. This article provides a review of (a) US features of thyroid nodules with an emphasis on the predictive capacity for malignancy, focused on the pediatric age group when the data exist, (b) clinical information, including risk factors and genetic syndromes pertinent to the pediatric population, and (c) the state of the current literature and controversies in diagnosing and managing pediatric thyroid cancer. RSNA, 2017.

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The Role of Thyroid FNA Cytology in Pediatric Malignant Lesions: Case Illustrations and Literature Review

Rossi

2023

Thyroid FNA Cytology

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Pediatric thyroid nodules: A single center experience

Cited by 15 publications

References 15 publications

The role of thyroid FNA cytology in pediatric malignant lesions: An overview of the literature

The role of thyroid FNA cytology in pediatric malignant lesions: An overview of the literature

Sonographic Evaluation of Pediatric Thyroid Nodules

The Role of Thyroid FNA Cytology in Pediatric Malignant Lesions: Case Illustrations and Literature Review

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