Pefloxacin

Bergogne-Bérézin, E

doi:10.1016/0924-8579(91)90020-e

Cited by 7 publications

(3 citation statements)

References 73 publications

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“…In general, the reactions have not been severe enough to cause blistering. Phototoxic reactions associated with the newer quinolones are common enough to require thorough systematic investigation [4,[22][23][24]. Most difficult to determine objectively at this point are the relative phototoxicities of the various quinolones on the market.…”

Section: Resultsmentioning

confidence: 99%

Photosensitivity and the quinolones

Mirensky¹,

Parish²

1995

Acad Dermatol Venereol

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Section: Resultsmentioning

confidence: 99%

Photosensitivity and the quinolones

Mirensky¹,

Parish²

1995

Acad Dermatol Venereol

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“…Once bacterial cells are exposed to pefloxacin, they induce non-replicative DNA synthesis (DNA repair), also known as the SOS response, which is believed to protect bacteria from further DNA damage by preventing replication, inhibiting cell division and producing filamentation. [25] Pefloxacin drug acts as a bidentate ligand and binds to metal ions through one of the carboxylic and pyridone oxygen atoms.…”

Section: Introductionmentioning

confidence: 99%

Theoretical, in Vitro Antiproliferative, and in Silico Molecular Docking and Pharmacokinetics Studies of Heteroleptic Nickel(II) and Copper(II) Complexes of Thiosemicarbazone‐Based Ligands and Pefloxacin

Ahmed,

Mahendiran,

Bhat

et al. 2023

Chemistry & Biodiversity

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Twelve new heteroleptic nickel(II) and copper(II) complexes of the type [M(L1–6)(Pfx)2] (1–12), where L1–6=2‐benzylidenehydrazinecarbothioamide (L1), 2‐benzylidene‐N‐methylhydrazinecarbothioamide (L2), 2‐benzylidene‐N‐phenylhydrazinecarbothioamide (L3), 2‐(4‐methylbenzylidene)hydrazinecarbothioamide (L4), 2‐(4‐methylbenzylidene)‐N‐methylhydrazinecarbothioamide (L5) and 2‐(4‐methylbenzylidene)‐N‐phenylhydrazinecarbothioamide (L6), Pfx=pefloxacin and M=Ni(II) or Cu(II) have been synthesised, and their structures were confirmed by different spectral techniques. The spectral data and density functional theory (DFT) calculations supported the bonding of pefloxacin drug molecule via one of the carboxylate oxygen atoms and the pyridone oxygen atom, and the thiosemicarbazone ligand via the imine nitrogen and the thione sulfur atoms with the metal(II) ion, forming distorted octahedral geometry. In vitro antiproliferative activity of the synthesized complexes was evaluated against three human breast cancer (T47D, estrogen negative (MDA‐MB‐231) and estrogen positive (MCF‐7)) as well as non‐tumorigenic human breast epithelial (MCF‐10a) cell lines, which showed the higher activity for the copper(II) complexes. The interaction of the synthesized complexes with an oncogenic protein H‐ras (121 p) was explored by in silico molecular docking studies. Further, in silico pharmacokinetics and ADMET parameters were also analysed to predict the drug‐likeness as well as non‐toxic and non‐carcinogenic behavior, and safe oral administration of the complexes.

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“…With normal liver and kidney function, about half of the injected drug is excreted through the kidneys unchanged or in the form of metabolites. About 30% is found in the intestine unchanged and in the form of metabolites [11][12][13]. Erbisol class preparations contain low-molecular-weight "signaling" fragments of membrane glycoproteins that perform the function of "markers of the physiological state of cells", which, in case of pathological homeostasis disorders, activate the natural evolutionarily formed controlling systems of the body responsible for finding and eliminating pathological changes in organs and tissues.…”

Section: Introductionmentioning

confidence: 99%