PEG- b -PLA micelles and PLGA- b -PEG- b -PLGA sol–gels for drug delivery

Cho, Hyunah; Gao, Jieming; Kwon, Glen S.

doi:10.1016/j.jconrel.2015.12.015

Cited by 151 publications

(106 citation statements)

References 65 publications

(104 reference statements)

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“…From the 1980s until nowadays, a huge development in the sol-gel process was achieved. The research conducted allowed them to obtain OIH materials with applications in a wide range of areas, such as chemical and biosensors [13,85,86], in several transduction modes, from electrochemical [87][88][89][90][91] to optical [13,[92][93][94][95]; biomaterials for drug delivery [24,[96][97][98][99][100]; materials for improving bioactivity and biocompatibility of metallic substrates [101][102][103][104][105][106][107][108]; electronics [14]; environment [109][110][111]; optics [13,112,113]; medicine [53,[114][115][116][117]; functional smart coatings [31,38,73,118]; fuel and solar cells [119][120][121]…”

Section: Sol-gel Process: a Historical Perspective And Applicationsmentioning

confidence: 99%

Hybrid Sol–gel Coatings for Corrosion Mitigation: A Critical Review

Figueira

2020

Polymers

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The corrosion process is a major source of metallic material degradation, particularly in aggressive environments, such as marine ones. Corrosion progression affects the service life of a given metallic structure, which may end in structural failure, leakage, product loss and environmental pollution linked to large financial costs. According to NACE, the annual cost of corrosion worldwide was estimated, in 2016, to be around 3%-4% of the world's gross domestic product. Therefore, the use of methodologies for corrosion mitigation are extremely important. The approaches used can be passive or active. A passive approach is preventive and may be achieved by emplacing a barrier layer, such as a coating that hinders the contact of the metallic substrate with the aggressive environment. An active approach is generally employed when the corrosion is set in. That seeks to reduce the corrosion rate when the protective barrier is already damaged and the aggressive species (i.e., corrosive agents) are in contact with the metallic substrate. In this case, this is more a remediation methodology than a preventive action, such as the use of coatings. The sol-gel synthesis process, over the past few decades, gained remarkable importance in diverse areas of application. Sol-gel allows the combination of inorganic and organic materials in a single-phase and has led to the development of organic-inorganic hybrid (OIH) coatings for several applications, including for corrosion mitigation. This manuscript succinctly reviews the fundamentals of sol-gel concepts and the parameters that influence the processing techniques. The state-of-the-art of the OIH sol-gel coatings reported in the last few years for corrosion protection, are also assessed. Lastly, a brief perspective on the limitations, standing challenges and future perspectives of the field are critically discussed.Polymers 2020, 12, 689 The development of OIH sol-gel coatings, based on siloxanes, for corrosion mitigation, has been widely studied in the last few years [2,31,[36][37][38]. Numerous studies have been conducted since the early 1990s [39,40]. The studies performed showed that siloxanes were effective in mitigating the corrosion processes of different metallic substrates. This development was mainly due to the need for alternative environmentally friend materials and processes to replace the traditional chromium-based pre-treatments. Hexavalent chromium (Cr (VI)) is carcinogenic and shows high environmental toxicity and its use has been forbidden since 2006. However, Cr(VI) based pre-treatments improve the coating adherence to the substrate and are effective corrosion inhibitors [41][42][43] which make its replacement challenging. The use of the sol-gel method to produce OIH coatings for corrosion mitigation suits the main requirements of what should be an environmentally friendly process (i.e., excludes washing stages; it is a waste-free method) and allows one to obtain coatings with high purity and specific pore volumes and surface areas. Since it is a mild synthesis...

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Section: Sol-gel Process: a Historical Perspective And Applicationsmentioning

confidence: 99%

Hybrid Sol–gel Coatings for Corrosion Mitigation: A Critical Review

Figueira

2020

Polymers

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“…1 Genexol-PM ® is approved in Asia, and in a phase 3 clinical trial, the bioequivalence of Cynviloq ™ and Abraxane ® (nanoparticle albumin-bound PTX) is being evaluated in the USA. 2 Thus, PEG- b -PLA micelles possess a proven track record of safety, sterility and scale-up for clinical translation. However, low drug loading and poor stability against precipitation, e.g.…”

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confidence: 99%

Oligo(lactic acid)_n-Paclitaxel Prodrugs for Poly(ethylene glycol)-block-poly(lactic acid) Micelles: Loading, Release, and Backbiting Conversion for Anticancer Activity

2016

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Poly(ethylene glycol)-block-poly(D,L-lactic acid) (PEG-b-PLA) micelles are nanocarriers for poorly water-soluble anticancer agents and have advanced paclitaxel (PTX) into humans due to drug solubilization, biocompatibility and dose escalation. However, PEG-b-PLA micelles rapidly release PTX, resulting in widespread biodistribution and low tumor exposure. To improve delivery of PTX by PEG-b-PLA micelles, monodisperse oligo(L-lactic acid), o(LA)8 or o(LA)16, has been coupled onto PTX at the 7-OH position, forming ester prodrugs: o(LA)8-PTX and o(LA)16-PTX, respectively. As expected, o(LA)n-PTX was more compatible with PEG-b-PLA micelles than PTX, increasing drug loading from 11 to 54%. While in vitro release of PTX was rapid, resulting in precipitation, o(LA)n-PTX release was more gradual: t1/2 = 14 and 26 hours for o(LA)8-PTX and o(LA)16-PTX, respectively. Notably, o(LA)8-PTX and o(LA)16-PTX in PEG-b-PLA micelles resisted backbiting chain end scission, based on reverse-phase HPLC analysis. By contrast, o(LA)8-PTX and o(LA)16-PTX degraded substantially in 1:1 acetonitrile:10 mM PBS, pH 7.4, at 37 °C, generating primarily o(LA)2-PTX. The IC50 value of o(LA)2-PTX was ca. 2.3 nM for A549 human lung cancer cells, equipotent with PTX in vitro. After weekly IV injection at 20 mg/kg as PEG-b-PLA micelles, o(LA)8-PTX induced tumor regression in A549 tumor-bearing mice, whereas PTX delayed tumor growth. Surprisingly, o(LA)8-PTX caused less toxicity than PTX in terms of change in body weight. In conclusion, o(LA)n acts as a novel promoiety, undergoing backbiting conversion without a reliance on metabolizing enzymes, and o(LA)n-PTX improves PTX delivery by PEG-b-PLA micelles, providing a strong justification for clinical evaluation.

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“…Taking advantage of nanoscience and nanotechnology, several nano-formulations of chemical drugs are commercially available, such as Genexol-PM ® and Triolimus. [16] In addition to chemical drugs, many other therapeutic agents (genes, proteins, photosensitizers, etc.) have been developed and applied to treat cancers.…”

Section: Combination Therapymentioning

confidence: 99%

Co‐Delivery of Drugs and Genes Using Polymeric Nanoparticles for Synergistic Cancer Therapeutic Effects

Thambi

Lee

2017

Adv Healthcare Materials

107

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Drug and gene delivery systems based on nanoparticles, microparticles and hydrogels have been widely studied for cancer treatment in the past decade. To achieve an efficient and safe delivery, selection of drug and gene delivery carrier is critical. Biocompatible polymeric nanoparticles are considerably promising carrier candidates in delivery of drugs and genes because of their unique chemical and physical properties. However, delivery of a drug or gene sometimes cannot achieve a satisfactory treatment effect. Therefore, co‐delivery of dual drugs or co‐delivery of a drug and a gene in a polymeric nanoparticle has attracted attention. Such co‐delivery systems can overcome multi‐drug resistance of chemical drugs and achieve a synergistic therapeutic effect. In this progress report, we summarize recent progress in the preparation and application of polymeric drug and gene co‐delivery nanosystems. The remaining challenges and future trends in this field are also included.

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PEG- b -PLA micelles and PLGA- b -PEG- b -PLGA sol–gels for drug delivery

Cited by 151 publications

References 65 publications

Hybrid Sol–gel Coatings for Corrosion Mitigation: A Critical Review

Hybrid Sol–gel Coatings for Corrosion Mitigation: A Critical Review

Oligo(lactic acid)_n-Paclitaxel Prodrugs for Poly(ethylene glycol)-block-poly(lactic acid) Micelles: Loading, Release, and Backbiting Conversion for Anticancer Activity

Co‐Delivery of Drugs and Genes Using Polymeric Nanoparticles for Synergistic Cancer Therapeutic Effects

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PEG- b -PLA micelles and PLGA- b -PEG- b -PLGA sol–gels for drug delivery

Cited by 151 publications

References 65 publications

Hybrid Sol–gel Coatings for Corrosion Mitigation: A Critical Review

Hybrid Sol–gel Coatings for Corrosion Mitigation: A Critical Review

Oligo(lactic acid)n-Paclitaxel Prodrugs for Poly(ethylene glycol)-block-poly(lactic acid) Micelles: Loading, Release, and Backbiting Conversion for Anticancer Activity

Co‐Delivery of Drugs and Genes Using Polymeric Nanoparticles for Synergistic Cancer Therapeutic Effects

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Product

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Oligo(lactic acid)_n-Paclitaxel Prodrugs for Poly(ethylene glycol)-block-poly(lactic acid) Micelles: Loading, Release, and Backbiting Conversion for Anticancer Activity