PEG‐Citrate dendrimer second generation: is this a good carrier for imaging agents In Vitro and In Vivo ?

Abstract

While cancer is the leading cause of human's deaths worldwide, finding an imaging agent which can detect cancer tumours is needed for cancer diagnosis. In the present study, PEG-citrate dendrimer-G 2 was used as a nano-carrier of FITC dye and Iohexol to help passive targeting and uptake of both imaging agents in cancer cells/tumour in vitro and in vivo. Dendrimer was synthesisedand the product characterised using LC-MS, FT-IR, DLS, ELS, AFM, and 1 HNMR. After FITC loading into dendrimer, MTT was performed to determine the cytotoxicity of formulation on HEK-293 and MCF-7 cells. In vitro imaging using dendrimer-FITC was done via fluorescent microscope thereafter. Moreover, CT imaging using Iohexol was employed to show the targeting nature and ability of the complex to use as imaging agent in vivo. Data yielded in this study corroborate the notion that the promised dendrimer was synthesised properly and had no toxicity along with FITC on normal cell. Furthermore, CT and fluorescent images showed the targeting nature and imaging ability of Iohexol/FITC loaded dendrimer in vitro and in vivo. Overall, results showed promising characteristics of the novel complexes using dendrimer-G 2 both in vitro and in vivo.

Investigation of the Characteristics and Antibacterial Activity of Polymer-Modified Copper Oxide Nanoparticles

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“…Advancements in medical technology have achieved new milestones, with innovative diagnostic methods and new treatment processes [ 1 ]. Public health-related issues, such as cancers, Alzheimer’s disease, cerebrovascular disease, bacterial infection, viruses, etc., which were previously considered to be incurable diseases, are now being effectively managed and controlled.…”

Facile and eco‐benign synthesis of a novel MnFe2O4@SiO2@Au magnetic nanocomposite with antibacterial properties and enhanced photocatalytic activity under UV and visible‐light irradiations

“…Up to now, different researches have been made to preparation of nanomaterials and explore their application in various fields . Nowadays, organic and dye contaminants are one of the most concern to the environment .…”

Comparison of Aerosol Pt, Au and Ag Nanoparticles Agglomerates Laser Sintering

“…However, the comparison of this metal with Pt and Ag is also of great interest and defines the novelty of the work considering the sintering mechanisms of nanoparticles right in the aerosol phase. These materials are of fundamental importance for a variety of catalytic [ 12 ] and plasmonic [ 13 ] applications such as photocatalysis [ 14 , 15 , 16 ], synthesis of reactive oxygen species [ 17 , 18 ], imaging [ 13 , 19 ], detection of chemical and biological substances [ 20 ], and others.…”