PEG-interpenetrated genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier compound formulation for topical drug administration

Li, Qijun; Gong, Shiqiang; Yao, Weifan; Yu, Yancun; Liu, Chao; Wang, Renjun; Pan, Hao

doi:10.1080/21691401.2021.1879104

Cited by 13 publications

(7 citation statements)

References 51 publications

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“…As shown in Figure S1, the characteristic peak at 3290 cm –1 of spectrum [A] was due to the −NH stretching vibrations of the aromatic ring of clozapine, and the bands observed at 2773, 2800, 2934, and 2970 cm –1 corresponded to the aliphatic −CH stretching of clozapine. , The FTIR spectrum of oleic acid [B] showed peaks at 2853 and 2922 cm –1 , which were associated with symmetric and asymmetric −CH 2 stretching bands, respectively. The peak at 1708 cm –1 was due to the CO stretch of oleic acid. , The P407 spectrum [C] showed characteristic peaks at 2883 cm –1 (−CH stretching), 1467 cm –1 (−CH 2 bending), 1342 cm –1 (−OH bending), and 1100 cm –1 (C–O stretching). , The bands observed for the PS80 spectra [D] were 3503 cm –1 (−OH stretching), 2921 cm –1 (−CH 2 stretching), 2860 cm –1 (CH 3 stretching), 1735 cm –1 (CO stretching), and 1097 cm –1 (C–O–C stretching). , In the propylene glycol spectrum [E], the broad absorption band at 3308–3310 cm –1 was ascribed to −OH stretching, while 2970, 2930, and 2875 cm –1 were due to −CH stretching and 1040 cm –1 was due to C–O stretching vibrations . The CLZ-NESG spectra [F] showed a wide absorption band at 3688–3032 cm –1 (−OH stretching) due to the presence of PS80 and propylene glycol (at 10% w / w ) in the formulation.…”

Section: Resultsmentioning

confidence: 99%

“…51,52 The P407 spectrum [C] showed characteristic peaks at 2883 cm −1 (−CH stretching), 1467 cm −1 (−CH 2 bending), 1342 cm −1 (−OH bending), and 1100 cm −1 (C−O stretching). 53,54 The bands observed for the PS80 spectra [D] were 3503 cm −1 (−OH stretching), 2921 cm −1 (−CH 2 stretching), 2860 cm −1 (CH 3 stretching), 1735 cm −1 (C�O stretching), and 1097 cm −1 (C−O−C stretching). 55,56 In the propylene glycol spectrum 4.5.…”

Section: Dsc and Tga Studiesmentioning

confidence: 99%

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Fabrication and Characterization of Clozapine Nanoemulsion Sol–Gel for Intranasal Administration

et al. 2022

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Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia. However, it causes many adverse drug reactions (ADRs), which lead to poor treatment outcomes. Nose-to-brain (N2B) drug delivery offers a promising approach to reduce peripheral ADRs by minimizing systemic drug exposure. The aim of the present study was to develop and characterize clozapine-loaded nanoemulsion sol−gel (CLZ-NESG) for intranasal administration using high energy sonication method. A range of oils, surfactants, and cosurfactants were screened with the highest clozapine solubility selected for the development of nanoemulsion. Pseudoternary phase diagrams were constructed using a low-energy (spontaneous) method to identify the microemulsion regions (i.e., where mixtures were transparent). The final formulation, CLZ-NESG (pH 5.5 ± 0.2), comprising 1% w/w clozapine, 1% w/w oleic acid, 10% w/w polysorbate 80/propylene glycol (3:1), and 20% w/w poloxamer 407 (P407) solution, had an average globule size of ≤30 nm with PDI 0.2 and zeta potential of −39.7 ± 1.5 mV. The in vitro cumulative drug release of clozapine from the nanoemulsion gel at 34 °C (temperature of nasal cavity) after 72 h was 38.9 ± 4.6% compared to 84.2 ± 3.9% with the control solution. The permeation study using sheep nasal mucosa as diffusion barriers confirmed a sustained release of clozapine with 56.2 ± 2.3% cumulative drug permeated after 8 h. Additionally, the histopathological examination found no severe nasal ciliotoxicity on the mucosal tissues. The thermodynamic stability studies showed that the gel strength and viscosity of CLZ-NESG decreased after temperature cycling but was still seen to be in "gel" form at nasal temperature. However, the accelerated storage stability study showed a decrease in drug concentration after 3 months, which can be expected at elevated stress conditions. The formulation developed in this study showed desirable physicochemical properties for intranasal administration, highlighting the potential value of a nanoemulsion gel for improving drug bioavailability of clozapine for N2B delivery.

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Section: Resultsmentioning

confidence: 99%

Section: Dsc and Tga Studiesmentioning

confidence: 99%

Fabrication and Characterization of Clozapine Nanoemulsion Sol–Gel for Intranasal Administration

et al. 2022

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“…After loading the alpha-lipoic acid (ALA) nanostructured lipid carrier (ALA-NLC) with high efficiency, experiments showed that increasing PEG accelerated the drug release rate. 72 In another study, gold nanoparticles embedded in P407 showed excellent colloidal stability and slow and sustained drug release behavior. 73…”

Section: Temperature Sensitive Hydrogelsmentioning

confidence: 96%

Aggressive strategies for regenerating intervertebral discs: stimulus-responsive composite hydrogels from single to multiscale delivery systems

Gao

Zhang

et al. 2022

J. Mater. Chem. B

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“…However, alginate-based dressings have poor structural stability . Therefore, strategies like plasticization have been used to reduce intermolecular attractive forces between polymer chains and improve the structural stability of alginate-based aerogels. , Moreover, the transdermal delivery of ALA in a poly(ethylene glycol)-plasticized aerogel is improved . Thus, alginate aerogels can be designed to control bleeding, exudate, and superficial infection and to deliver molecules.…”

Section: Introductionmentioning

confidence: 99%

Radical Scavenging, Hemocompatibility, and Antibacterial Activity against MDR Acinetobacter baumannii in Alginate-Based Aerogels Containing Lipoic Acid-Capped Silver Nanoparticles

Martínez-García,

Zertuche-Arias,

Bernáldez-Sarabia

et al. 2024

ACS Omega

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Retaining the hemocompatibility, supporting cell growth, and exhibiting anti-inflammatory and antioxidant properties, while having antimicrobial activity, particularly against multidrug-resistant bacteria (MDR), remain a challenge when designing aerogels for biomedical applications. Here, we report that our synthesized alginate-based aerogels containing either 7.5 or 11.25 μg of lipoic acid-capped silver nanoparticles (AgNPs) showed improved hemocompatibility properties while retaining their antimicrobial effect against MDR Acinetobacter baumannii and the reference strain Escherichia coli, relative to a commercial dressing and polymyxin B, used as a reference. The differences in terms of the microstructure and nature of the silver, used as the bioactive agent, between our synthesized aerogels and the commercial dressing used as a reference allowed us to improve several biological properties in our aerogels with respect to the reference commercial material. Our aerogels showed significantly higher antioxidant capacity, in terms of nmol of Trolox equivalent antioxidant capacity per mg of aerogel, than the commercial dressing. All our synthesized aerogels showed anti-inflammatory activity, expressed as nmol of indomethacin equivalent anti-inflammatory activity per mg of aerogel, while this property was not found in the commercial dressing material. Finally, our aerogels were highly hemocompatible (less than 1% hemolysis ratio); however, the commercial material showed a 20% hemolysis rate. Therefore, our alginate-based aerogels with lipoic acid-capped AgNPs hold promise for biomedical applications.

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PEG-interpenetrated genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier compound formulation for topical drug administration

Abstract: 2021) PEG-interpenetrated genipin-crosslinked dual-sensitive hydrogel/ nanostructured lipid carrier compound formulation for topical drug administration, Artificial Cells,

Cited by 13 publications

References 51 publications

Fabrication and Characterization of Clozapine Nanoemulsion Sol–Gel for Intranasal Administration

Fabrication and Characterization of Clozapine Nanoemulsion Sol–Gel for Intranasal Administration

Aggressive strategies for regenerating intervertebral discs: stimulus-responsive composite hydrogels from single to multiscale delivery systems

Radical Scavenging, Hemocompatibility, and Antibacterial Activity against MDR Acinetobacter baumannii in Alginate-Based Aerogels Containing Lipoic Acid-Capped Silver Nanoparticles

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