1999
DOI: 10.1038/sj.gt.3300900
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PEGylated DNA/transferrin–PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery

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Cited by 1,152 publications
(979 citation statements)
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“…PEG incorporated into DNA complexes of cationic polymers can reduce their surface charge [25,26,31,34], cytotoxicity [25,27,31] and interaction with blood components [25], as well as prevent aggregation through steric stabilization [25,26,[29][30][31]33,34]. Because of its ability to modulate the properties of complexes, PEG has been reported to enhance transfection when attached to polymer-DNA complexes directly [24,27,33,34] or simply added to transfection media containing lipoplexes [49].…”
Section: Transfection On Sams On Goldmentioning
confidence: 99%
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“…PEG incorporated into DNA complexes of cationic polymers can reduce their surface charge [25,26,31,34], cytotoxicity [25,27,31] and interaction with blood components [25], as well as prevent aggregation through steric stabilization [25,26,[29][30][31]33,34]. Because of its ability to modulate the properties of complexes, PEG has been reported to enhance transfection when attached to polymer-DNA complexes directly [24,27,33,34] or simply added to transfection media containing lipoplexes [49].…”
Section: Transfection On Sams On Goldmentioning
confidence: 99%
“…Polyethylene glycol (PEG), which has the monomeric repeat unit [-CH 2 -CH 2 -O]-, is widely used in drug and gene delivery and has been incorporated into DNA complexes of several cationic polymers, including polymethacrylate [23], PEI [24][25][26][27][28][29][30][31][32], PLL [33][34][35] and poly(amidoamine)s [36]. PEG reduces the surface charge of the complexes [25,26,31,34], which in turn reduces cytotoxicity [25,27,31]. The shielding effect of PEG also reduces the interaction between the complex and blood components (plasma proteins and erythrocytes) [25], and can prolong circulation of the complexes in the blood stream [25,32].…”
Section: Introductionmentioning
confidence: 99%
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