PEGylated liposomes enhance the effect of cytotoxic drug: A review

Taher, Muhammad; Susanti, Deny; Haris, Muhammad Salahuddin; Rushdan, Aina Atiqah; Widodo, Riyanto Teguh; Syukri, Yandi; Khotib, Junaidi

doi:10.1016/j.heliyon.2023.e13823

Cited by 26 publications

(13 citation statements)

References 72 publications

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“…Recent improvements in liposome formulations have shown reduced toxicity and enhanced the effectiveness of treatment for drug-resistant tumors. 92 The lipid membrane of liposomes, comprised of cholesterol, dihexyl phosphate, and egg yolk phosphatidylcholine, makes curcumin soluble. 93 The positively charged nanoliposomes are produced using cationic polyethyleneimine (PEI) and PEG to transport curcumin.…”

Section: Liposomementioning

confidence: 99%

“…They are tiny and one of the best structures to deliver anticancer drugs to the body. Recent improvements in liposome formulations have shown reduced toxicity and enhanced the effectiveness of treatment for drug‐resistant tumors 92 . The lipid membrane of liposomes, comprised of cholesterol, dihexyl phosphate, and egg yolk phosphatidylcholine, makes curcumin soluble 93 .…”

Section: Nanotechnology‐based Curcumin Delivery Platformsmentioning

confidence: 99%

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Curcumin, its derivatives, and their nanoformulations: Revolutionizing cancer treatment

Ahmad,

Ahmad

et al. 2024

Cell Biochemistry & Function

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Curcumin is a natural compound derived from turmeric and can target malignant tumor molecules involved in cancer propagation. It has potent antioxidant activity, but its effectiveness is limited due to poor absorption and rapid elimination from the body. Various curcumin derivatives have also shown anticancer potential in in‐vitro and in‐vivo models. Curcumin can target multiple signaling pathways involved in cancer development/progression or induce cancer cell death through apoptosis. In addition, curcumin and its derivatives could also enhance the effectiveness of conventional chemotherapy, radiation therapy and reduce their associated side effects. Lately, nanoparticle‐based delivery systems are being developed/explored to overcome the challenges associated with curcumin's delivery, increasing its overall efficacy. The use of an imaging system to track these formulations could also give beneficial information about the bioavailability and distribution of the nano‐curcumin complex. In conclusion, curcumin holds significant promise in the fight against cancer, especially in its nanoform, and could provide precise delivery to cancer cells without affecting normal healthy cells.

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Section: Liposomementioning

confidence: 99%

Section: Nanotechnology‐based Curcumin Delivery Platformsmentioning

confidence: 99%

Curcumin, its derivatives, and their nanoformulations: Revolutionizing cancer treatment

Ahmad,

Ahmad

et al. 2024

Cell Biochemistry & Function

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“…Hence, reducing the reticuloendothelial system attack and liver clearance improves the drug's half-life. 144 Actively targeted liposomes are prepared by conjugation with small molecules, peptides, antibodies, and aptamers to target the desired site, selective cell internalization, drug release, targeted imaging, and triggered response capability. Liposomes can carry all these agents simultaneously, providing multifunctional liposomes.…”

Section: Lipid Nanoparticles In Drug Deliverymentioning

confidence: 99%

Material and Design Toolkit for Drug Delivery: State of the Art, Trends, and Challenges

Rad,

Soylukan,

Kulabhusan

et al. 2023

ACS Appl. Mater. Interfaces

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“…Most chemotherapy drugs are designed to block intracellular functions of biomacromolecules like nucleic acids via a transmembrane transport, but the drugs are not always delivered to the intended targets adequately, which remains a major obstacle in clinic application . Recruiting carriers like various liposomes has proven an inspired approach to protecting drugs from degradation during blood circulation. − Additionally, it is crucial to improve the penetration of drug molecules on the targeted cell membrane evolving into specific phases. Given potential changes in membrane organization like lateral heterogeneous and leaflet asymmetry as a result of cell cancerization, to sustain or enhance the membrane permeability of drugs by innovating the drug-carrier systems is a critical project.…”

Section: Introductionmentioning

confidence: 99%

Dynamic Simulations of Interaction of the PEG-DPPE Micelle-Encapsulated Short-Chain Ceramides with the Raft-Included Membrane

Zhao,

Wang,

Zhang

et al. 2024

J. Chem. Inf. Model.

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The lipid raft subdomains in cancer cell membranes play a key role in signal transduction, biomolecule recruitment, and drug transmembrane transport. Augmented membrane rigidity due to the formation of a lipid raft is unfavorable for the entry of drugs, a limiting factor in clinical oncology. The short-chain ceramide (CER) has been reported to promote drug entry into membranes and disrupt lipid raft formation, but the underlying mechanism is not well understood. We recently explored the carrier-membrane fusion dynamics of PEG-DPPE micelles in delivering doxorubicin (DOX). Based on the phase-segregated membrane model composed of DPPC/DIPC/ CHOL/GM1/PIP2, we aim to explore the dynamic mechanism of the PEG-DPPE micelle-encapsulating DOXs in association with the raft-included cell membrane modulated by C8 acyl tail CERs. The results show that the lipid raft remains integrated and DOX-resistant subjected to free DOXs and the micelle-encapsulating ones. Addition of CERs disorganizes the lipid raft by pushing CHOL aside from DPPC. It subsequently allows for a good permeability for PEG-DPPE micelle-encapsulated DOXs, which penetrate deeper as CER concentration increases. GM1 is significant in guiding drugs' redistributing between bilayer phases, and the anionic PIP2 further helps DOXs attain the inner bilayer surface. These results elaborate on the perturbing effect of CERs on lipid raft stability, which provides a new comprehensive approach for further design of drug delivery systems.

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PEGylated liposomes enhance the effect of cytotoxic drug: A review

Cited by 26 publications

References 72 publications

Curcumin, its derivatives, and their nanoformulations: Revolutionizing cancer treatment

Curcumin, its derivatives, and their nanoformulations: Revolutionizing cancer treatment

Material and Design Toolkit for Drug Delivery: State of the Art, Trends, and Challenges

Dynamic Simulations of Interaction of the PEG-DPPE Micelle-Encapsulated Short-Chain Ceramides with the Raft-Included Membrane

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