PEGylated superparamagnetic iron oxide nanoparticles (SPIONs) ameliorate learning and memory deficit in a rat model of Alzheimer’s disease: Potential participation of STIMs

Sanati, Mehdi; Aminyavari, Samaneh; Khodagholi, Fariba; Hajipour, Mohammad Javad; Sadeghi, Payam; Noruzi, Marzieh; Moshtagh, Aynaz; Behmadi, Homayoon; Sharifzadeh, Mohammad

doi:10.1016/j.neuro.2021.05.013

Cited by 24 publications

(8 citation statements)

References 106 publications

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“…It improves cognitive function significantly and alleviates AD neuropathology in the mice model [94]. It was also observed that PEGylated superparamagnetic iron oxide nanoparticles ameliorated memory and learning deficit by inhibiting A␤ aggregation and elevating the levels of hippocampal protein, brain-derived neurotrophic factor, and phosphorylated-cAMP response element binding protein [95]. All these studies prove that iron oxide nanoparticles can be used to treat AD.…”

Section: Effect Of Iron Oxide Nanoparticles In Admentioning

confidence: 77%

Metal Nanoparticles in Alzheimer’s Disease

Behera

Pradhan

et al. 2023

Journal of Alzheimer's Disease Reports

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Nanotechnology has emerged in different fields of biomedical application, including lifestyle diseases like diabetes, hypertension, and chronic kidney disease, neurodegenerative diseases like Alzheimer’s disease (AD), Parkinson’s disease, and different types of cancers. Metal nanoparticles are one of the most used drug delivery systems due to the benefits of their enhanced physicochemical properties as compared to bulk metals. Neurodegenerative diseases are the second most cause affecting mortality worldwide after cancer. Hence, they require the most specific and targeted drug delivery systems for maximum therapeutic benefits. Metal nanoparticles are the preferred drug delivery system, possessing greater blood-brain barrier permeability, biocompatibility, and enhanced bioavailability. But some metal nanoparticles exhibit neurotoxic activity owing to their shape, size, surface charge, or surface modification. This review article has discussed the pathophysiology of AD. The neuroprotective mechanism of gold, silver, selenium, ruthenium, cerium oxide, zinc oxide, and iron oxide nanoparticles are discussed. Again, the neurotoxic mechanisms of gold, iron oxide, titanium dioxide, and cobalt oxide are also included. The neuroprotective and neurotoxic effects of nanoparticles targeted for treating AD are discussed elaborately. The review also focusses on the biocompatibility of metal nanoparticles for targeting the brain in treating AD. The clinical trials and the requirement to develop new drug delivery systems are critically analyzed. This review can show a path for the researchers involved in the brain-targeted drug delivery for AD.

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Section: Effect Of Iron Oxide Nanoparticles In Admentioning

confidence: 77%

Metal Nanoparticles in Alzheimer’s Disease

Behera

Pradhan

et al. 2023

Journal of Alzheimer's Disease Reports

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“…Sanati et al. showed that PEG-modified SPIONs significantly limited spatial memory impairment and neuronal oxidative damage in AD mice [ 35 ]. Collectively, IONPs have shown great advantages and potential in biomedical applications.…”

Section: Discussionmentioning

confidence: 99%

Mannose-coated superparamagnetic iron oxide nanozyme for preventing postoperative cognitive dysfunction

Zhu¹,

Huang²,

Zhu³

et al. 2023

Materials Today Bio

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“…The tank was divided into four equal quadrants including northeast (NE), northwest (NW), southeast (SE), and southwest (SW) by EthoVision tracking system software (Noldus Information Technology, Wageningen, The Netherlands). 27 A dark hidden platform was placed in a fixed position in the center of the NE quadrant and submerged below the surface of the water (approximately 2 cm). Several pictures as extra‐maze visual cues were hung around the tank.…”

Section: Methodsmentioning

confidence: 99%

“…In short, the water maze composes of a standard black circular tank (150 cm diameter, 70 cm height, 45 cm deep) filled with water at 22 ± 1°C to a depth of 30 cm. The tank was divided into four equal quadrants including northeast (NE), northwest (NW), southeast (SE), and southwest (SW) by EthoVision tracking system software (Noldus Information Technology, Wageningen, The Netherlands) 27 . A dark hidden platform was placed in a fixed position in the center of the NE quadrant and submerged below the surface of the water (approximately 2 cm).…”

Section: Methodsmentioning

confidence: 99%

MicroRNA‐140‐5p inhibitor attenuates memory impairment induced by amyloid‐ß oligomer in vivo possibly through Pin1 regulation

et al. 2022

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Aims The peptidyl‐prolyl cis/trans isomerase, Pin1, has a protective role in age‐related neurodegeneration by targeting different phosphorylation sites of tau and the key proteins required to produce Amyloid‐β, which are the well‐known molecular signatures of Alzheimer's disease (AD) neuropathology. The direct interaction of miR‐140‐5p with Pin1 mRNA and its inhibitory role in protein translation has been identified. The main purpose of this study was to investigate the role of miRNA‐140‐5p inhibition in promoting Pin1 expression and the therapeutic potential of the AntimiR‐140‐5p in the Aß oligomer (AßO)‐induced AD rat model. Methods Spatial learning and memory were assessed in the Morris water maze. RT‐PCR, western blot, and histological assays were performed on hippocampal samples at various time points after treatments. miRNA‐140‐5p inhibition enhanced Pin1 and ADAM10 mRNA expressions but has little effect on Pin1 protein level. Results The miRNA‐140‐5p inhibitor markedly ameliorated spatial learning and memory deficits induced by AßO, and concomitantly suppressed the mRNA expression of inflammatory mediators TNFα and IL‐1β, and phosphorylation of tau at three key sites (thr231, ser396, and ser404) as well as increased phosphorylated Ser473‐Akt. Conclusion According to our results, Antimir‐140‐mediated improvement of AβO‐induced neuronal injury and memory impairment in rats may provide an appropriate rationale for evaluating miR‐140‐5p inhibitors as a promising agent for the treatment of AD.

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PEGylated superparamagnetic iron oxide nanoparticles (SPIONs) ameliorate learning and memory deficit in a rat model of Alzheimer’s disease: Potential participation of STIMs

Cited by 24 publications

References 106 publications

Metal Nanoparticles in Alzheimer’s Disease

Metal Nanoparticles in Alzheimer’s Disease

Mannose-coated superparamagnetic iron oxide nanozyme for preventing postoperative cognitive dysfunction

MicroRNA‐140‐5p inhibitor attenuates memory impairment induced by amyloid‐ß oligomer in vivo possibly through Pin1 regulation

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