PEI-based functional materials: Fabrication techniques, properties, and biomedical applications

Fattahi, Nadia; Gorgannezhad, Lena; Masoule, Shabnam Farkhonde; Babanejad, Niloofar; Ramazani, Ali; Raoufi, Mohammad; Sharifikolouei, Elham; Foroumadi, Alireza; Khoobi, Mehdi

doi:10.1016/j.cis.2024.103119

Cited by 13 publications

(1 citation statement)

References 455 publications

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“…Cationic polymers have received an important role in various applications, such as drug and gene delivery systems, antimicrobial agents, surfactants for organo-modification of layered silicates, and many others [ 79 , 80 , 81 , 82 ]. Here, many synthetic and naturally-based cationic polymers, e.g., poly(ethylene imine), poly(amino acids), and chitosan, have been used for aforementioned applications [ 83 , 84 , 85 , 86 , 87 ]. From the family of poly(2-oxazolines), partially hydrolyzed poly(2-alkyl-2-oxazolines) have been used as cationic vectors for gene delivery [ 88 , 89 , 90 , 91 ].…”

Section: Poly(2-isopropenyl-2-oxazoline) In Biomedical Applicationsmentioning

confidence: 99%

Poly(2-isopropenyl-2-oxazoline) as a Versatile Functional Polymer for Biomedical Applications

Kronek,

Minarčíková,

Kroneková

et al. 2024

Polymers

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Functional polymers play an important role in various biomedical applications. From many choices, poly(2-isopropenyl-2-oxazoline) (PIPOx) represents a promising reactive polymer with great potential in various biomedical applications. PIPOx, with pendant reactive 2-oxazoline groups, can be readily prepared in a controllable manner via several controlled/living polymerization methods, such as living anionic polymerization, atom transfer radical polymerization (ATRP), reversible addition–fragmentation transfer (RAFT) or rare earth metal-mediated group transfer polymerization. The reactivity of pendant 2-oxazoline allows selective reactions with thiol and carboxylic group-containing compounds without the presence of any catalyst. Moreover, PIPOx has been demonstrated to be a non-cytotoxic polymer with immunomodulative properties. Post-polymerization functionalization of PIPOx has been used for the preparation of thermosensitive or cationic polymers, drug conjugates, hydrogels, brush-like materials, and polymer coatings available for drug and gene delivery, tissue engineering, blood-like materials, antimicrobial materials, and many others. This mini-review covers new achievements in PIPOx synthesis, reactivity, and use in biomedical applications.

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Section: Poly(2-isopropenyl-2-oxazoline) In Biomedical Applicationsmentioning

confidence: 99%

Poly(2-isopropenyl-2-oxazoline) as a Versatile Functional Polymer for Biomedical Applications

Kronek,

Minarčíková,

Kroneková

et al. 2024

Polymers

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Radiosensitization of breast cancer cells with AgBiS₂ nanodots: Preparation and in vitro evaluations

Xue,

Pilehvar,

Afshari

et al. 2024

Applied Organom Chemis

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Radiotherapy (RT), which is a therapeutic treatment modality that is commonly used for cancer, employs high‐energy irradiation to induce the generation of reactive oxygen species (ROS) and to cause DNA damages. Nevertheless, the therapeutic efficacy of RT is predominantly constrained due to inadequate DNA damage in malignancies and deleterious impacts on healthy tissues. In the current study, bovine serum albumin (BSA)–coated AgBiS2 nanodots, also known as AgBiS2@ BSA nanodots, were developed for enhanced breast cancer treatment. This was accomplished by the use of an extremely simple and eco‐friendly method. Both scanning transmission electron microscopy (STEM) and scanning electron microscopy (SEM) images revealed that prepared nanoradiosensitizers, AgBiS2@ BSA, were spherical in shape and uniformly distributed. AgBiS2@ BSA nanodots possessed excellent biocompatibility and exhibit excellent monodispersity as well. Furthermore, in vitro assays such as MTT, colony formation assay, and intracellular ROS generation assay revealed the significant cell inhibitory impact of the produced AgBiS2@ BSA nanodots under X‐ray irradiation under X‐ray irradiation. Remarkably, the combined administration of AgBiS2@ BSA nanodots along with X‐ray irradiation increased ROS level within cells by increasing the localized radiation dosage and improving the anti‐tumor effectiveness of RT.

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Nanoparticle‐Mediated Gene Delivery for Bone Tissue Engineering

Li,

Wu,

Cheng

et al. 2024

Small

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Critical‐sized bone defects represent an urgent clinical problem, necessitating innovative treatment approaches. Gene‐activated grafts for bone tissue engineering have emerged as a promising solution. However, traditional gene delivery methods are constrained by limited osteogenic efficacy and safety concerns. Recently, organic and inorganic nanoparticle (NP) vectors have attracted significant attention in bone tissue engineering for their safe, stable, and controllable gene delivery. Targeted gene delivery guided by insights into bone healing mechanisms, coupled with the multifunctional design of NPs, is crucial for enhancing therapeutic outcomes. Here, the theoretical foundations underlying NP‐mediated gene therapy for enhancing bone healing across different histological stages are elucidated. Furthermore, the distinct attributes of functionalized NP vectors are discussed, and cutting‐edge strategies aimed at optimizing gene delivery efficiency throughout the therapeutic process are highlighted. Additionally, the review addresses the unresolved challenges and prospects of this technology. This review may contribute to the continued development and clinical application of NP‐mediated gene delivery for treating critical‐sized bone defects.

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PEI-based functional materials: Fabrication techniques, properties, and biomedical applications

Cited by 13 publications

References 455 publications

Poly(2-isopropenyl-2-oxazoline) as a Versatile Functional Polymer for Biomedical Applications

Poly(2-isopropenyl-2-oxazoline) as a Versatile Functional Polymer for Biomedical Applications

Radiosensitization of breast cancer cells with AgBiS₂ nanodots: Preparation and in vitro evaluations

Nanoparticle‐Mediated Gene Delivery for Bone Tissue Engineering

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PEI-based functional materials: Fabrication techniques, properties, and biomedical applications

Cited by 13 publications

References 455 publications

Poly(2-isopropenyl-2-oxazoline) as a Versatile Functional Polymer for Biomedical Applications

Poly(2-isopropenyl-2-oxazoline) as a Versatile Functional Polymer for Biomedical Applications

Radiosensitization of breast cancer cells with AgBiS2 nanodots: Preparation and in vitro evaluations

Nanoparticle‐Mediated Gene Delivery for Bone Tissue Engineering

Contact Info

Product

Resources

About

Radiosensitization of breast cancer cells with AgBiS₂ nanodots: Preparation and in vitro evaluations