Pelvic and sacral morphology and their correlation with pelvic incidence, lumbar lordosis, and lumbar alignment changes between standing and sitting postures

Hey, Hwee Weng Dennis; Tan, Jun-Hao; Ong, Biauw Chi; Kumar, Akshay; Liu, Gabriel; Wong, Hee‐Kit

doi:10.1016/j.clineuro.2021.107019

Cited by 4 publications

(3 citation statements)

References 42 publications

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“…PT is the magnitude in which the pelvis rotates around the femoral heads while SS characterizes the S1 endplate position and these values comprise PI (PI = PT + SS) which is anatomically fixed, specific for each individual, and solidified after adolescence [ 5 , 7 ]. Realignment of the lumbar spine to PI has been shown to improve outcomes [ 8 , 9 ], and PT and SS are clinical predictors as well [ 5 , [10] , [11] , [12] ]. LL has typically been measured from L1-S1 while TK varies but is generally measured from T1-12 or T5-12.…”

Section: Introductionmentioning

confidence: 99%

“…However, these studies primarily look at the difference in measurements from sitting to standing and correlate to disease severity or pre- and post-operation. Studies in healthy populations are now emerging that show significant changes in measures between sitting and standing radiograph markers that may even be influenced by age, gender, and other modifications in body position [ 3 , 12 , 17 , 20 , [36] , [37] , [38] , [39] , [40] ]. Additionally, work is being performed in the artificial neural network space to predict sitting measures based on standing radiographs to inform surgical correction [ [41] , [42] , [43] ].…”

Section: Introductionmentioning

confidence: 99%

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Sagittal balance in sitting and standing positions: A systematic review of radiographic measures

Dharnipragada,

Bostrom,

Bertogliat

et al. 2024

Heliyon

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sagittal balance in sitting and standing positions: A systematic review of radiographic measures

Dharnipragada,

Bostrom,

Bertogliat

et al. 2024

Heliyon

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“…The rapidly evolving concepts in adult spinal deformity surgery have highlighted the importance of realigning the sagittal profile of the spine 8 , 9 . Considerations in spinal realignment include assessment of a deformity using the sagittal vertical axis (SVA), and the pelvic incidence (PI) – lumbar lordosis (LL) discrepancy, as well as appreciating the extent of spinopelvic compensation using the pelvic tilt (PT) 9 , 10 . Retrolisthesis, which was once regarded as a possible form of spinal instability of unknown significance 11 , is now being increasingly recognized today as a compensatory process which occurs in patients with positive sagittal imbalance 9 , 11 .…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Risk Factors of Degenerative Spondylolisthesis and Retrolisthesis in the Thoracolumbar and Lumbar Spine – An EOS Study Using Updated Radiographic Parameters

Hey

Low

Soh

et al. 2023

Global Spine Journal

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Study design Single centre, cross-sectional study. Objectives The objective is to report the prevalence of spondylolisthesis and retrolisthesis, analyse both conditions in terms of the affected levels and severity, as well as identify their risk factors. Methods A review of clinical data and radiographic images of consecutive spine patients seen in outpatient clinics over a 1-month period is performed. Images are obtained using the EOS® technology under standardised protocol, and radiographic measurements were performed by 2 independent, blinded spine surgeons. The prevalence of both conditions were shown and categorised based on the spinal level involvement and severity. Associated risk factors were identified. Results A total of 256 subjects (46.1% males) with 2304 discs from T9/10 to L5/S1 were studied. Their mean age was 52.2(± 18.7) years. The overall prevalence of spondylolisthesis and retrolisthesis was 25.9% and 17.1% respectively. Spondylolisthesis occurs frequently at L4/5(16.3%), and retrolisthesis at L3/4(6.8%). Majority of the patients with spondylolisthesis had a Grade I slip (84.3%), while those with retrolisthesis had a Grade I slip. The presence of spondylolisthesis was found associated with increased age ( P < .001), female gender (OR: 2.310; P = .005), predominantly sitting occupations (OR:2.421; P = .008), higher American Society of Anaesthesiology grades ( P = .001), and lower limb radiculopathy (OR: 2.175; P = .007). Patients with spondylolisthesis had larger Pelvic Incidence ( P < .001), Pelvic Tilt ( P < .001) and Knee alignment angle ( P = .011), but smaller Thoracolumbar junctional angle ( P = .008), Spinocoxa angle ( P = .007). Retrolisthesis was associated with a larger Thoracolumbar junctional angle ( P =.039). Conclusion This is the first study that details the prevalence of spondylolisthesis and retrolisthesis simultaneously, using the EOS technology and updated sagittal radiographic parameters. It allows better understanding of both conditions, their mutual relationship, and associated clinical and radiographic risk factors.

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Low expression of Ki-67/MIB-1 labeling index in IDH wild type glioblastoma predicts prolonged survival independently by MGMT methylation status

et al. 2023

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Purpose The Ki-67/MIB-1 labeling index (LI) is clinically used to differentiate between high and low-grade gliomas, while its prognostic value remains questionable. Glioblastoma (GBM) expressing wild-type isocitrate dehydrogenase IDHwt, a relatively common malignant brain tumor in adults, is characterized by a dismal prognosis. Herein, we have retrospectively investigated the prognostic role of Ki-67/MIB-1-LI in a large group of IDHwt GBM. Methods One hundred nineteen IDHwt GBM patients treated with surgery followed by Stupp’s protocol in our Institution between January 2016 and December 2021 were selected. A cut-off value for Ki-67/MIB-1-LI was used with minimal p-value based approach. Results A multivariate analysis showed that Ki-67/MIB-1-LI expression < 15% significantly correlated with a longer overall survival (OS), independently from the age of the patients, Karnofsky performance status scale, extent of surgery and O6-methylguanine (O6-MeG)-DNA methyltransferase promoter methylation status. Conclusions Among other studies focused on Ki-67/MIB-1-LI, this is the first observational study showing a positive correlation between OS of IDHwt GBM patients and Ki-67/MIB-1-LI that we propose as a new predictive marker in this subtype of GBM.

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Pelvic and sacral morphology and their correlation with pelvic incidence, lumbar lordosis, and lumbar alignment changes between standing and sitting postures

Cited by 4 publications

References 42 publications

Sagittal balance in sitting and standing positions: A systematic review of radiographic measures

Sagittal balance in sitting and standing positions: A systematic review of radiographic measures

Prevalence and Risk Factors of Degenerative Spondylolisthesis and Retrolisthesis in the Thoracolumbar and Lumbar Spine – An EOS Study Using Updated Radiographic Parameters

Low expression of Ki-67/MIB-1 labeling index in IDH wild type glioblastoma predicts prolonged survival independently by MGMT methylation status

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