Pelvic Limb Paresis, Paralysis, or Ataxia

Lorenz, Michael D.; Coates, Joan R.; Kent, Marc

doi:10.1016/b978-1-4377-0651-2.10006-2

Cited by 23 publications

(39 citation statements)

References 224 publications

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“…They are usually considered as an incidental age related finding, however, in rare cases they were thought to have caused functional effects such as hyperesthesia of 1 or both thoracic limbs, progressive paresis, ataxia, atrophy of the limb musculature, urine retention, and incontinence. 101,105 In 1 report a 6-year-old Ragdoll cat with neurological signs had ventrally located dural plaques of osseous metaplasia on the C3-C5 segments and caudal lumbar areas. 3 The etiology of dural ossification remains unknown.…”

Section: Meningeal Lesionsmentioning

confidence: 99%

Pathology of the Aging Brain in Domestic and Laboratory Animals, and Animal Models of Human Neurodegenerative Diseases

et al. 2016

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According to the WHO, the proportion of people over 60 years is increasing and expected to reach 22% of total world's population in 2050. In parallel, recent animal demographic studies have shown that the life expectancy of pet dogs and cats is increasing. Brain aging is associated not only with molecular and morphological changes but also leads to different degrees of behavioral and cognitive dysfunction. Common age-related brain lesions in humans include brain atrophy, neuronal loss, amyloid plaques, cerebrovascular amyloid angiopathy, vascular mineralization, neurofibrillary tangles, meningeal osseous metaplasia, and accumulation of lipofuscin. In aging humans, the most common neurodegenerative disorder is Alzheimer's disease (AD), which progressively impairs cognition, behavior, and quality of life. Pathologic changes comparable to the lesions of AD are described in several other animal species, although their clinical significance and effect on cognitive function are poorly documented. This review describes the commonly reported age-associated neurologic lesions in domestic and laboratory animals and the relationship of these lesions to cognitive dysfunction. Also described are the comparative interspecies similarities and differences to AD and other human neurodegenerative diseases including Parkinson's disease and progressive supranuclear palsy, and the spontaneous and transgenic animal models of these diseases.

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Section: Meningeal Lesionsmentioning

confidence: 99%

Pathology of the Aging Brain in Domestic and Laboratory Animals, and Animal Models of Human Neurodegenerative Diseases

et al. 2016

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“…Selection of the treatment method depends on the degree of the clinical condition in each case [9]. In general, steroids are administered and cage rest suggested in conservative treatment.…”

mentioning

confidence: 99%

Inflammatory Reaction in the Herniated Degenerative Disc Materials in Miniature Dachshunds

Shimizu

Mochida

Kobayashi

et al. 2010

The Journal of Veterinary Medical Science

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ABSTRACT. Histological and immunohistochemical studies were conducted using herniated intervertebral disc materials obtained surgically from 39 miniature dachshunds. Infiltration of inflammatory cells, such as macrophages, neutrophils, T or B lymphocytes, and multinucleated giant cells, were identified in intervertebral disc materials in 23 cases. Furthermore, proliferations of connective tissue, including neovascularization, were also observed in 17 cases. These results suggest that spontaneous regression of herniated intervertebral disc material could occur in affected dogs.

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“…Os sinais clínicos manifestam-se logo após o nascimento e dependem da gravidade das malformações da coluna vertebral, medula espinhal e da cauda equina (CHRISMAN et al, 2005), podendo ser estáveis ou progressivos (LECOUTEUR & GRANDY, 2004;LORENZ & KORNEGAY, 2004;DEWEY, 2006). As lesões caudais ao sexto segmento lombar (L 6 ) da medula espinhal comprometem as raízes nervosas que contribuem para a formação dos nervos pélvicos, pudendos, isquiáticos e caudais, promovendo disfunções dos neurônios motores inferiores viscerais e dos membros pélvicos (MACIEL et al, 2002;COATS, 2004;LORENZ & KORNEGAY, 2004).…”

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“…As lesões caudais ao sexto segmento lombar (L 6 ) da medula espinhal comprometem as raízes nervosas que contribuem para a formação dos nervos pélvicos, pudendos, isquiáticos e caudais, promovendo disfunções dos neurônios motores inferiores viscerais e dos membros pélvicos (MACIEL et al, 2002;COATS, 2004;LORENZ & KORNEGAY, 2004).…”

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“…Pode-se observar agenesia sacrococcígea em radiografias simples, e a mielografia pode indicar malformação nas meninges (LECOUTEUR & GRANDY, 2004;CHRISMAN et al, 2005 A frequente inexistência de estruturas anatômicas para a inervação do ânus e da bexiga urinária determina a impossibilidade de qualquer tratamento (DEWEY, 2006). Nesses casos, os animais podem ser mantidos a partir de esvaziamento manual da bexiga urinária e da administração de emolientes fecais (CHRISMAN, 1991;LORENZ & KORNEGAY, 2004).…”

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